Wheeseong Lee | Researchain

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Featured researches published by Wheeseong Lee.

Bioorganic & Medicinal Chemistry Letters | 2003

Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

Bin Ye; Shawn M. Bauer; Brad O. Buckman; Ameen Ghannam; Brian D. Griedel; Seock Kyu Khim; Wheeseong Lee; Karna Lyn Sacchi; Kenneth J. Shaw; Amy Liang; Qingyu Wu; Zuchun Zhao

Compound 1 was identified by high throughput screening as a novel PAI-1 inhibitor. Optimization of the B and C-segments of 1 resulted in a series of structurally simplified compounds with improved potency. The synthesis and SAR data of these compounds are presented here.

Archive | 1998

Ortho-anthranilamide derivatives as anti-coagulants

Damian O. Arnaiz; Yuo-Ling Chou; Brian D. Griedel; Rushad E Karanjawala; Monica J. Kochanny; Wheeseong Lee; Amy Liang; Michael M. Morrissey; Gary Phillips; Karna Lyn Sacchi; Stephen T Sakata; Kenneth J. Shaw; R Michael Snider; Shung C. Wu; Bin Ye; Zuchun Zhao

Bioorganic & Medicinal Chemistry Letters | 2007

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity.

Imadul Islam; Judi Bryant; Yuo-Ling Chou; Monica J. Kochanny; Wheeseong Lee; Gary Phillips; Hongyi Yu; Marc Adler; Marc Whitlow; Elena Ho; Dao Lentz; Mark A. Polokoff; Babu Subramanyam; James M. Wu; Daguang Zhu; Richard I. Feldman; Damian O. Arnaiz

Journal of Medicinal Chemistry | 2007

Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.

Bin Ye; Damian O. Arnaiz; Yuo-Ling Chou; Brian D. Griedel; Rushad E Karanjawala; Wheeseong Lee; Michael M. Morrissey; Karna Lyn Sacchi; Steven T. Sakata; Kenneth J. Shaw; Shung C. Wu; Zuchun Zhao; Marc Adler; Sarah Cheeseman; William P. Dole; Janice Ewing; Richard M. Fitch; Dao Lentz; Amy Liang; David Light; John Morser; Joseph Post; Galina Rumennik; Babu Subramanyam; Mark E. Sullivan; Ron Vergona; Janette Walters; Yi-Xin Wang; Kathy White; Marc Whitlow

Archive | 2007

Dihydropyridine derivatives useful as protein kinase inhibitors

Marc Adler; Stefan Baeurle; Judi Bryant; Ming Chen; Yuo-Ling Chou; Paul Hrvatin; Seock-Kyu Khim; Monica Kochanny; Wheeseong Lee; Michael Mamounas; Ogden Janet Meurer; Gary Phillips; Victor Selchau; Christopher West; Bin Ye; Shendong Yuan; Martin Krueger

Archive | 2003

Substituted quinoline ccr5 receptor antagonists

Laura Dunning; Stefan Jaroch; Monica J. Kochanny; Wheeseong Lee; Xiongdong Lian; Meina Liang; Shou-Fu Lu; James Onuffer; Gary Phillips; Guo-Ping Wei; Bin Ye

Archive | 2004

Indolinone derivatives and their use in treating disease-states such as cancer

Damian O. Arnaiz; Judi Bryant; Yuo-Ling Chou; Richard I. Feldman; Paul Hrvatin; Imadul Islam; Monica J. Kochanny; Wheeseong Lee; Mark A. Polokoff; Hongyi Yu; Shendong Yuan

Bioorganic & Medicinal Chemistry | 2007

Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.

Monica J. Kochanny; Marc Adler; Janice Ewing; Brian D. Griedel; Elena Ho; Rushad E Karanjawala; Wheeseong Lee; Dao Lentz; Amy Liang; Michael M. Morrissey; Gary Phillips; Joseph Post; Karna Lyn Sacchi; Steven T. Sakata; Babu Subramanyam; Ron Vergona; Janette Walters; Kathy White; Marc Whitlow; Bin Ye; Zuchun Zhao; Kenneth J. Shaw

Archive | 2004