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Dive into the research topics where Wiesława Bylka is active.

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Featured researches published by Wiesława Bylka.


Phytotherapy Research | 2014

Centella asiatica in Dermatology: An Overview

Wiesława Bylka; Paulina Znajdek-Awiżeń; Elżbieta Studzińska-Sroka; Aleksandra Dańczak-Pazdrowska; Małgorzata Brzezińska

Centella asiatica is a medicinal plant that was already used as a ‘panacea’ 3000 years ago. The active compounds include pentacyclic triterpenes, mainly asiaticoside, madecasosside, asiatic acid and madecassic acid. We have conducted an overview to summarize current knowledge on the results of scientific in vitro and in vivo experiments focused on the improvement of the healing process of small wounds, hypertrophic scars and burns by C. asiatica. In this paper, we discuss the data on constituents, recommended preparations and the potential side effects of C. asiatica. Copyright


Postepy Dermatologii I Alergologii | 2013

Centella asiatica in cosmetology

Wiesława Bylka; Paulina Znajdek-Awiżeń; Elżbieta Studzińska-Sroka; Małgorzata Brzezińska

Centella asiatica known as Gotu Kola is a medicinal plant that has been used in folk medicine for hundreds of years as well as in scientifically oriented medicine. The active compounds include pentacyclic triterpenes, mainly asiaticoside, madecassoside, asiatic and madecassic acids. Centella asiatica is effective in improving treatment of small wounds, hypertrophic wounds as well as burns, psoriasis and scleroderma. The mechanism of action involves promoting fibroblast proliferation and increasing the synthesis of collagen and intracellular fibronectin content and also improvement of the tensile strength of newly formed skin as well as inhibiting the inflammatory phase of hypertrophic scars and keloids. Research results indicate that it can be used in the treatment of photoaging skin, cellulite and striae.


Acta Physiologiae Plantarum | 2001

Sulphated flavonoid glycosides from leaves of Atriplex hortensis

Wiesława Bylka; Maciej Stobiecki; Rafał Frański

Two flavonoid sulphates, i.e. quercetin 3-O-sulphate-7-O-α-arabinopyranoside and kaempferol 3-O-sulphate-7-O-α-arabinopyranoside, were isolated from leaves of Atriplex hortensis L. The structures of these compounds were established by UV, 1H and 13C NMR, 2D NMR and MS spectra. The compounds were isolated for the first time from plant material.


Environmental Toxicology and Pharmacology | 2006

Protective effect of Aquilegia vulgaris L. on aflatoxin B1-induced hepatic damage in rats

Jadwiga Jodynis-Liebert; Irena Matławska; Wiesława Bylka; Marek Murias

The aim of the study was to investigate the effect of ethanol and ethyl acetate extract obtained from Aquilegia vulgaris L. on microsomal lipid peroxidation, reduced glutathione level and antioxidant enzymes activity in the liver of rats intoxicated with aflatoxin B(1) (AFB(1)). Animals were pretreated with 12 daily p.o. doses of the extracts tested (100mg/kg body weight). Then AFB(1) was administered intraperitoneally at a single dose of 1.5mg/kg b.w. to evoke the liver damage. α-Tocopherol was used as a positive control. Reduced glutathione (GSH) was depleted in aflatoxin-treated rats by 80% in comparison with that in the controls. The extracts restored the GSH concentration up to the basal level. Microsomal lipid peroxidation stimulated by Fe(2+)/ascorbate (assessed by measuring TBARS) was enhanced in AFB(1)-treated rats by 28% as compared to that in the control group. The extracts caused a decrease in TBARS level by 40% and 27%. Only two antioxidant enzymes were affected by AFB(1) administration. The activity of catalase was reduced by 24% and the activity of glutathione-S-transferase (GST) was increased by 33%. The pretreatment with ethyl acetate and ethanol extract reduced the GST activity by 76% and 30%, respectively. No significant changes in the activity of other antioxidant enzymes were observed in rats treated with the extracts and AFB(1). It can be concluded that multiple pretreatment with the extracts obtained from A. vulgaris attenuated aflatoxin B(1)-induced hepatic damage as evidenced by inhibition of lipid peroxidation and preventing reduced glutathione depletion.


Acta Physiologiae Plantarum | 2010

Essential oil composition of Taraxacum officinale

Wiesława Bylka; Irena Matławska; Rafał Frański

The gas chromatography–mass spectrometry (GC–MS) analysis of essential oil obtained by hydrodistillation from the flower of Taraxacum officinale L. revealed the presence of 25 compounds with 1,3-dimethylbenzene, 1,2-dimethylbenzene, 1-ethyl-3-methylbenzene, heneicosane and tricosane as the main components.


Acta Physiologiae Plantarum | 2004

A new acylated flavonol diglycoside from Atriplex littoralis

Wiesława Bylka

A new acetylated flavonol glycoside: patuletin 3-O-[5′″-O-feruloyl-β-D-apiofuransyl (1′″→2′′)-β-D-glucopyranoside] (2), together with a known patuletin 3-O-β-D-glucopyranoside (1) were isolated from the aerial part of Artiplex littoralis L. (Chenopodiacease). Their structures were elcidated by acid hydrolysis and spectroscopic methods including UV, 1H, 13C NMR and ESI-MS for both compounds, additionally 2D-NMR, HSQC, HMBC experiments were performed for 2.


Medical Science Monitor | 2012

Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritis.

Alicja E. Grzegorzewska; Dorota Frankiewicz; Danuta Bręborowicz; Irena Matławska; Wiesława Bylka

Summary Background To date, Kaposi sarcoma has not been mentioned among the adverse effects of triptolide/tripdiolide, ethyl acetate extracts or polyglycosides of the Chinese herbal remedy Tripterygium wilfordii Hook F. Case Report A patient was diagnosed with rheumatoid arthritis at the age of 29 years. She underwent treatment with corticosteroids, methotrexate and gold sodium thiosulfate, and was chronically taking ketoprofen. At the age of 59 years she started to take a powder (≈2 g/day) from a Chinese physician for treatment of rheumatoid arthritis. This powder was supplied to her regularly for 10 years. At the age of 69 years, multiple soft, violaceous to dark-red patches, plaques, nodules and blisters of varying sizes appeared on a background of severely edematous skin on her legs, and later on her arms. Biopsy specimens of the leg lesions were diagnostic for human herpesvirus 8-associated Kaposi sarcoma. Triptolide (235 μg/1 g) and tripdiolide were found in the Chinese powder by the use of Liquid Chromatography Electrospray Ionization Mass Spectrometry. Administration of the powder was stopped and medication with paclitaxel was introduced. General condition of the patient improved and skin lesions diminished significantly. Conclusions This case indicates a possible association between triptolide/tripdiolide chronic intake and development of human herpesvirus 8-associated Kaposi sarcoma. Triptolide/tripdiolide could contribute to development of Kaposi sarcoma by reactivation of latent human herpesvirus 8, permitted by immunosuppression induced by triptolide.


Natural Product Research | 2015

In vitro antimicrobial activity of extracts and compounds isolated from Cladonia uncialis

Elżbieta Studzińska-Sroka; Elżbieta Hołderna-Kędzia; Agnieszka Galanty; Wiesława Bylka; Karol Kacprzak; Karolina Ćwiklińska

Heptane (Hep), diethyl ether (Et2O), acetone (Me2CO) and methanolic (MeOH) extracts, as well as ( − )-usnic acid and squamatic acid, were obtained from thallus of Cladonia uncialis (Cladoniaceae). The antimicrobial activities of these extracts, ( − )-usnic acid and squamatic acid, were tested against reference strains: Staphylococcus aureus, Escherichia coli and Candida albicans. In addition, Me2CO extract was analysed against 10 strains of Methicillin-resistant S. aureus (MRSA) isolated from patients. All extracts exerted antibacterial activity against the reference strain S. aureus, comparably to chloramphenicol [minimum inhibitory concentration (MIC) = 5.0 μg/mL]. The Me2CO extract exhibited the strongest activity against S. aureus (MIC = 0.5 μg/mL), higher than ( − )-usnic acid, whereas squamatic acid proved inactive. The Me2CO extract showed potent antimicrobial activity against MRSA (MIC 2.5–7.5 μg/mL). Also no activity of C. uncialis extracts against E. coli and C. albicans was observed.


Pharmaceutical Biology | 2016

Cytotoxic activity of physodic acid and acetone extract from Hypogymnia physodes against breast cancer cell lines

Elżbieta Studzińska-Sroka; Hanna Piotrowska; Malgorzata Kucinska; Marek Murias; Wiesława Bylka

Abstract Context: Lichens produce specific secondary metabolites with different biological activity. Objective: This study investigated the cytotoxic effects of physodic acid, in addition to the total phenolic content and cytotoxic and antioxidant activity of acetone extract from Hypogymnia physodes (L.) Nyl. (Parmeliaceae). Materials and methods: Cytotoxicity of physodic acid (0.1–100 μM) was assessed in MDA-MB-231, MCF-7 and T-47D breast cancer cell lines and a nontumorigenic MCF-10A cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, neutral red uptake and crystal violet assays during 72 h of incubation. An MTT assay was also used to assess the cytotoxic effects of the acetone extract (0.1–100 μg/mL) in the MDA-MB-231, MCF-7, T-47D breast cancer cell lines after 72 h. The total phenolic content of the acetone extract, expressed as the gallic acid equivalent, was investigated using Folin-Ciocalteu reagent. The antioxidant activity of the extract was assessed by 2,2-diphenyl-1-picrylhydrazyl and ferric-reducing antioxidant power assays. Results: The cytotoxic activity of physodic acid appeared to be strong in the tumorigenic cell lines (IC50 46.0–93.9 μM). The compound was inactive against the nontumorigenic MCF-10A cell line (IC50 >100 μM). The acetone extract showed cytotoxicity in the breast cancer cell lines (IC50 46.2–110.4 μg/mL). The acetone extract was characterized by a high content of polyphenols, and it had significant antioxidant activity. Discussion and conclusion: Physodic acid and acetone extract from H. physodes displayed cytotoxic effects in the breast cancer cell lines. Furthermore, acetone extract from H. physodes possessed significant antioxidant properties.


Pharmaceutical Chemistry Journal | 2016

Chemical Composition, Antioxidant and Antimicrobial Activities of Sanguisorba officinalis L. Extracts

Anna Gawron-Gzella; Ewa Witkowska-Banaszczak; Wiesława Bylka; Marlena Dudek-Makuch; Agnieszka Odwrot; Natalia Skrodzka

Sanquisorba officinalis has been used internally for the treatment of intestinal infections and duodenal ulcers, as well as hemorrhoids, phlebitis and varicose veins and female disorders, and topically to heal wounds, burns, and ulcers. In our study, the antioxidant and antimicrobial activities, as well as quantitative analysis of polyphenols (phenolic acids, flavonoids and total polyphenols) in methanol and aqueous extracts from S. officinalis herbs are presented. A correlation between the antioxidant activity and composition of tested extracts indicates that flavonoids are the major compounds causing scavenging of free radicals. Higher content of flavonoids was found in the methanol extract, while the content of total phenolics was higher in the aqueous extract. Both extracts from S. officinalis herbs showed antioxidant activity and high antimicrobial activity in a wide spectrum of test strains.

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Irena Matławska

Poznan University of Medical Sciences

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Elżbieta Studzińska-Sroka

Poznan University of Medical Sciences

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Jadwiga Jodynis-Liebert

Poznan University of Medical Sciences

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Paulina Znajdek-Awiżeń

Poznan University of Medical Sciences

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Ewa Witkowska-Banaszczak

Poznan University of Medical Sciences

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Marek Murias

Poznan University of Medical Sciences

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Rafał Frański

Adam Mickiewicz University in Poznań

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Maciej Stobiecki

Polish Academy of Sciences

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Teresa Adamska

Poznan University of Medical Sciences

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Agnieszka Galanty

Jagiellonian University Medical College

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