William A. Jeffers

Observations on the results of subtotal adrenalectomy in the treatment of severe, otherwise intractable hypertension and their bearing on the mechanism by which hypertension is maintained.

Excerpt The desirability of more effective measures for the treatment of patients with severe arterial hypertension than those now available is conceded by most students of this subject. Although h...

The clinical course following adrenal resection and sympathectomy, of 82 patients with severe hypertension.

Excerpt INTRODUCTION Previous reports of our testing of operations for hypertension, combining adrenal resection with sympathectomy, have indicated encouraging results.1, 2, 3, 4The number of patie...

Quantitative evaluation of primary adrenal cortical deficiency in man

Abstract 1.1. A method designed to afford a quantitative appraisal of adrenal cortical functional capacity has been devised. It consists of a two-fold test: (1) a standard metabolic regimen capable of provoking acute adrenal insufficiency in the severely adrenal-deficient individual; and (2) powerful adrenal cortical stimulation by means of intravenous corticotrophin. 2.2. Classification of patients into one of four separate grades of adrenal cortical functional capacity is proposed on the basis of multiple criteria of response to each portion of the test. Intrinsic and extrinsic grounds for confidence in the accuracy of the method are presented.

Further observations on patients with severe hypertension subjected to adrenal resection and sympathectomy.

Excerpt INTRODUCTION It has now been four years since our first patient was submitted to adrenal resection and three years since the first report to this College.1We are aware that it may well requ...

SYSTEMIC LUPUS ERYTHEMATOSUS AND HYPERTENSION WITHOUT RENAL INSUFFICIENCY

Excerpt In the evaluation of patients with hypertension, specific etiologic factors such as coarctation of the aorta, unilateral renal disease or polycystic disease of the kidneys have been sought,...