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Dive into the research topics where William A. Manning is active.

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Featured researches published by William A. Manning.


Journal of Orthopaedic Research | 2016

Influence of increasing construct constraint in the presence of posterolateral deficiency at knee replacement: A biomechanical study.

William A. Manning; Alasdair Blain; Stephen Rushton; Lee M. Longstaff; Andrew A. Amis; David J. Deehan

When faced with posterolateral corner (PLC) deficiency, surgeons must choose a total knee replacement (TKR) construct that provides the appropriate level of constraint. This should match the internal constraint of the device to the soft tissue host laxity pattern. Little guidance is available peroperatively, with factors influencing final component choice remaining ill defined. This study aimed to quantify the effect of PLC insufficiency on the “envelope of laxity” (EoL) after TKR and the effect of increasingly component constraint upon knee behavior through a functional arc of flexion. Using computer navigation, mixed effect modeling and loaded cadaveric legs—laxity was quantified under separate states: the native knee, after implantation of a posterior stabilized (PS)‐TKR, after sectioning the lateral (fibular) collateral ligament and popliteus tendon (PS‐TKR‐PLC), and after re‐implantation with a semi‐constrained “total stabilized” knee replacement (TS‐TKR). Laxity was quantified from 0 to 110° of flexion for anterior draw, varus–valgus, and internal–external rotation. Implantation of the PS‐TKR was consistently associated with increased constraint when compared to the native knee. PLC sectioning led to significantly increased laxity during varus stress from mid to deep flexion. Revision to a TS‐TKR construct restored constraint mimicking that of the primary state but only for the arc of motion 0–90°. In a posterolateral deficient state, a fixed bearing semi‐constrained TS‐TKR restored the knee to near normal kinematics but this was only achieved from an arc of motion 0–90° of flexion. At higher flexion angles, there remained an unfavorable laxity pattern with varus stress opening.


Journal of Orthopaedic Research | 2017

Lateral soft‐tissue structures contribute to cruciate‐retaining total knee arthroplasty stability

Kiron K. Athwal; Hadi El Daou; Breck R. Lord; Andrew Davies; William A. Manning; Ferdinando Rodriguez y Baena; David J. Deehan; Andrew A. Amis

Little information is available to surgeons regarding how the lateral structures prevent instability in the replaced knee. The aim of this study was to quantify the lateral soft‐tissue contributions to stability following cruciate‐retaining total knee arthroplasty (CR TKA). Nine cadaveric knees were tested in a robotic system at full extension, 30°, 60°, and 90° flexion angles. In both native and CR implanted states, ±90 N anterior–posterior force, ±8 Nm varus–valgus, and ±5 Nm internal–external torque were applied. The anterolateral structures (ALS, including the iliotibial band), the lateral collateral ligament (LCL), the popliteus tendon complex (Pop T), and the posterior cruciate ligament (PCL) were transected and their relative contributions to stabilizing the applied loads were quantified. The LCL was found to be the primary restraint to varus laxity (an average 56% across all flexion angles), and was significant in internal–external rotational stability (28% and 26%, respectively) and anterior drawer (16%). The ALS restrained 25% of internal rotation, while the PCL was significant in posterior drawer only at 60° and 90° flexion. The Pop T was not found to be significant in any tests. Therefore, the LCL was confirmed as the major lateral structure in CR TKA stability throughout the arc of flexion and deficiency could present a complex rotational laxity that cannot be overcome by the other passive lateral structures or the PCL.


Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine | 2018

Early shape change behaviour of an uncemented contemporary hip cup: A cadaveric experiment replicating host bone behaviour through temperature control

William A. Manning; Thomas Pandorf; David J. Deehan; James P. Holland

Modular uncemented acetabular components are in common use. Fixation is dependent upon press-fit but the forces necessary to achieve initial stability of the construct at implantation may deform the shell and prevent optimal seating of the polyethylene liner insert. Previous work using single-time point measurements in uncontrolled ambient temperature poorly replicates the native state. A controlled study was performed to observe the time-dependent behaviour of an uncemented acetabular shell in the early phase after implantation into the human acetabulum at near physiological temperature. Using a previously validated cadaveric hip model at controlled near physiological temperature with standardised surgical technique, immediate and delayed shell geometry was determined. Eight custom made 3-mm-thick titanium alloy (TiAl6V4) shells were implanted into four cadavers (eight hips). Time-dependent shell deformation was determined using the previously validated ATOS Triple Scan III (ATOS) optical measurement system. The pattern of change in the shape of the surgically implanted shell was measured at three time points after insertion. We found a consistent pattern for quantitative and directional deformation of the shells. In addition, there was consistency for relaxation of the deformation with time. Immediate mean change in shell radius was 104 µm (standard deviation 32, range 67–153) relaxing to mean 96 µm (standard deviation 32, range 63–150) after 10 min and mean 92 µm (standard deviation 28, range 66–138) after 20 min. The clinical significance of this work is the finding of a time-dependent early deformation of acetabular titanium shells on insertion adjusted for near physiological temperature-controlled host bone.


Medical Engineering & Physics | 2018

Mechanical properties of cancellous bone from the acetabulum in relation to acetabular shell fixation and compared with the corresponding femoral head

Rianne van Ladesteijn; Holly Leslie; William A. Manning; James P. Holland; David J. Deehan; Thomas Pandorf; Richard M. Aspden

To gain initial stability for cementless fixation the acetabular components of a total hip replacement are press-fit into the acetabulum. Uneven stiffness of the acetabular bone will result in irregular deformation of the shell which may hinder insertion of the liner or lead to premature loosening. To investigate this, we removed bone cores from the ilium, ischium and pubis within each acetabulum and from selected sites in corresponding femoral heads from four cadavers for mechanical testing in unconfined compression. From a stress-relaxation test over 300 s, the residual stress, its percentage of the initial stress and the stress half-life were calculated. Maximum modulus, yield stress and energy to yield (resilience) were calculated from a load-displacement test. Acetabular bone had a modulus about 10-20%, yield stress about 25% and resilience about 40% of the values for the femoral head. The stress half-life was typically between 2-4 s and the residual stress was about 60% of peak stress in both acetabulum and femur. Pubic bone was mechanically the poorest. These results may explain uneven deformation of press-fit acetabular shells as they are inserted. The measured half-life of stress-relaxation indicates that waiting a few minutes between insertion of the shell and the liner may allow seating of a poorly congruent liner.


Knee Surgery, Sports Traumatology, Arthroscopy | 2018

A load-measuring device can achieve fine-tuning of mediolateral load at knee arthroplasty but may lead to a more lax knee state

William A. Manning; Alasdair Blain; Lee M. Longstaff; David J. Deehan

PurposeA balanced knee arthroplasty should optimise survivorship and performance. Equilibration of medial and lateral femorotibial load requires guided judicious pericapsular ligament release. The null hypothesis was that there would be no difference between use of a tensiometer device and a remote load sensor final load transfer across the joint through functional arc of motion.MethodsA cadaveric study, using eight knees, was performed to define the impact of an established gap distraction device against load sensor-aimed soft tissue release in a TKA setting. Using validated measures of laxity in six degrees of freedom and true real-time load sensing four states were examined: native knee, TKA using spacer blocks (TKA), TKA with soft tissue release aided by a monogram tensiometer (TKA-T) and finally where load across the tibiofemoral articulation remains unbalanced final soft tissue release using a sensor device (TKA-OS).ResultsThe laxity pattern was equivalent for TKA-T and TKA-OS. However, in only four of these seven knees despite the tensiometer confirming equivalence of rectangular flexion–extension gap dimensions and centralisation of collateral ligament distraction, there remained a > 15lb medial to lateral load difference for at least one point of the flexion arc. This was corrected by further final soft tissue release guided by the OS sensor device in the final three knees.ConclusionTensiometer-guided soft tissue release at two points of flexion failed to achieve balance for three out of seven knee arthroplasty procedures. Sensor technology guided final soft tissue balancing to equilibrate load across the joint through full arc of motion. This work argues for the role of continuous sensor readings to guide the soft tissue balancing during total knee arthroplasty.


Journal of Arthroplasty | 2013

Henry's Pelvic Deltoid: Antiquated Concept or Important Consideration for Total Hip Arthroplasty? An Anatomical Study

Deborah Lees; William A. Manning; T. J. Joyce; A. W. McCaskie; Craig Gerrand

The relevance of Henrys pelvic deltoid and its contribution to hip abductor strength is often not considered in hip arthroplasty. This small cadaveric study (n = 11) aimed to quantify the relative contributions of the pelvic deltoid muscles to abductor strength and to assess how different surgical approaches(anterolateral, direct lateral and posterior) impact on each of these muscle groups. We inspected the path of each approach and measured the cross-sectional area of the hip abductors, from which the contribution of each muscle to abductor moment was derived. We concluded that the posterior approach has the least impact on the pelvic deltoid and overall abductor moment.


Knee Surgery, Sports Traumatology, Arthroscopy | 2017

Tibiofemoral forces for the native and post-arthroplasty knee: relationship to maximal laxity through a functional arc of motion

William A. Manning; Alasdair Blain; Lee M. Longstaff; David J. Deehan


Acta Orthopaedica Belgica | 2011

Outcome of hip resurfacing in obese patients.

Jonathan M. Loughead; William A. Manning; James P. Holland


Knee Surgery, Sports Traumatology, Arthroscopy | 2017

An in vitro analysis of medial structures and a medial soft tissue reconstruction in a constrained condylar total knee arthroplasty

Kiron K. Athwal; Hadi El Daou; Eivind Inderhaug; William A. Manning; Andrew Davies; David J. Deehan; Andrew A. Amis


Knee Surgery, Sports Traumatology, Arthroscopy | 2018

Internal femoral component rotation adversely influences load transfer in total knee arthroplasty: a cadaveric navigated study using the Verasense device

William A. Manning; Alasdair Blain; Lee M. Longstaff; Stephen Rushton; David J. Deehan

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Lee M. Longstaff

University Hospital of North Durham

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Andrew Davies

University of Southampton

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Hadi El Daou

Imperial College London

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