William Alexander Wylie

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Featured researches published by William Alexander Wylie.

Bioorganic & Medicinal Chemistry Letters | 2001

The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa

Stuart Donald Jones; John Walter Liebeschuetz; Phillip John Morgan; Christopher W. Murray; Andrew David Rimmer; Jonathan Michael Ernest Roscoe; Bohdan Waszkowycz; Pauline Mary Welsh; William Alexander Wylie; Stephen Clinton Young; Harry Martin; Jacqui Mahler; Leo Brady; Kay Wilkinson

Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa.

Journal of Medicinal Chemistry | 2002

Pro_Select: Combining Structure-Based Drug Design and Array-Based Chemistry for Rapid Lead Discovery. 2. The Development of a Series of Highly Potent and Selective Factor Xa Inhibitors

John Walter Liebeschuetz; Stuart Donald Jones; Phillip John Morgan; Chris W. Murray; Andrew David Rimmer; Jonathan Michael Ernest Roscoe; Bohdan Waszkowycz; Pauline Mary Welsh; William Alexander Wylie; Stephen Young; Harry Martin; Jacqui Mahler; Leo Brady; Kay Wilkinson

Journal of Chemical Information and Computer Sciences | 2000

New approach to molecular docking and its application to virtual screening of chemical databases

Carol A. Baxter; Christopher W. Murray; Bohdan Waszkowycz; Jin Li; Richard A. Sykes; Tim D. J. Perkins; William Alexander Wylie

Archive | 1998

1-amino-7-isoquinoline derivatives as serine protease inhibitors

John Walter Liebeschuetz; William Alexander Wylie; Bohdan Waszkowycz; Christopher William Murray; Andrew David Rimmer; Pauline Mary Welsh; Stuart Donald Jones; Jonathan Michael Ernest Roscoe; Stephen Clinton Young; Phillip John Morgan; Nicholas Paul Camp; Andrew Philip Austin Crew

Archive | 2001

Meta-benzamidine derivatives as serine protease inhibitors

Archive | 2005

DERIVADOS DE PROTEASA DE SERINA.

Nicholas Paul Camp; David Birenbaum Engel; Peter Robert Guzzo; Stuart Donald Jones; John Walter Liebeschuetz; John Joseph Masters; Michael John Mayer; Christopher William Murray; Scott Martin Sheehan; Brian Morgan Watson; Michael Robert Wiley; William Alexander Wylie; Stephen Clinton Young

Archive | 2003

Serine pretease inhibitors

John Walter Liebeschuetz; Christopher William Murray; Stephen Clinton Young; Nicholas Paul Camp; Stuart Donald Jones; William Alexander Wylie; John Joseph Masters; Michael Robert Wiley; Scott Martin Sheehan; David Birenbaum Engel; Brian Morgan Watson

Archive | 2001