William B. Kingsley

Electron Microscopical Observations on Mediastinal Neurolemmoma, Neurofibroma, and Ganglioneuroma

Abstract Observations on the ultrastructural morphology of benign mediastinal neurolemmoma, neurofibroma, and ganglioneuroma are presented. Distinguishing features of each tumor are described as observed in this study and reported in the literature. In neurolemmoma, the Antoni type A cells exhibit a cellular differentiation totally different from that of the Antoni B cells. The Antoni type A cells are characterized by numerous thin cytoplasmic processes emanating from a cell body with a narrow rim of cytoplasm. The Antoni type B cells lack these processes and have abundant cytoplasm which possesses a complex system of organelles. The extracellular compartment of Antoni type A tissue is composed of Iacunae outlined by lamina similar in appearance to the basement membrane surrounding the principal tumor cells. Neurofibroma is distinguished by elongated cells with a few thick cytoplasmic processes interspersed with occasional myelinated and unmyelinated axons in an extensive collagenous stroma. The principal tumor cells are distinguished from fibroblasts by the basement membrane coating their plasmalemma. Ganglioneuroma is characterized by the presence of large ganglion cells and their satellites and a vast number of myelinated and unmyelinated axons. A well-defined basement membrane coats the tumor cells. The small, membrane-bound osmiophilic granules encountered in the cytoplasm of ganglion cells have been observed in other tumors arising in sympathetic ganglia and paraganglionic cells.

Mesonephroma of the ovary. A report of five cases.

The clinical and pathologic findings of five cases of “mesonephroma” of the ovary are reported. A discussion of the histogenesis of these lesions is presented. Four of the five cases showed evidence of metastasis. Two of the four cases with metastases died 4 and 8 months after the diagnosis was made. Three patients are alive, well and show no evidence of recurrence at the present time after periods of 7, 9 and 12 years. Two of these patients had metastases at the time the diagnosis was first made.

Idiopathic Unilateral Hyperlucent Lung: The Swyer-James Syndrome

Once des:ribed and recorded in the literature , newly recûgnized syndromes are in increasing numbers. It is intended here to report twû additional cast:s which demonstrate the classic roentgenologic , fluoroscopic, bronc. hographic and cardioangiographic fmdings of idiopathic unilateral hyperlucent lung syndrome Case 1; The 23 year old Korean male , was addmited in ApriL 1966 for dyspnea , chest p:ün and hemoptysis Past history revealed frequent episode of pneumonia and bronchiolit is in the childhcod of his life. Physical examination showed wheezing on the left entire lung field , and rales with diminished breating sound on the left lower lung field. Pulmonary function test revealed decreased vital capacity and maximum breathing capacity and also 93. 4 per cent of oligemÎ:l. Roentgenological findings : a) P-A view of chest revealed unilateral hyperlucency on the left entire lung fleld with decreased pulmonary vascular pattern and small left hilum. Mediastinum and the heart were displaced to the left. A large cystic density was noted on the left upper medial lung field. b) Bronchogram revealed bronchiectasis at the entire bronchi with no alveolar filling. c) Angiocardiogram disclosed relatively small size of the left pulmonary artery caliber. d) Laminogram revealed a large cystic density on the 8, 9 and 10cm cuts from the posterior , indicating sub sternal mediastinal herniation of the right upper lobe Case 2; The 27 ye:lr old Korean male , was reffered for a routine chest examination in June , 1967. Past history revealed frequent episode of pneumonia in the childhood of his life. Roentgenologic findings: a) Fllloroscopy dllring respiration showed some restriction of the left hemidiaphragm with slight mediastinal shift, indicating obstructive emphysema. b) Angiocardiogram revealed smaller caliber of the left pulmonary artery than that of the right. c) Bronchogram demonstrated an lInusual type of diffllse termial bronchiectasis on the left side with poor al veolar filling

Staged radical pulmonary and chest wall resection for metastatic osteosarcoma. Report of a long-term survivor.

Abstract A long-term survivor of staged radical pulmonary and chest wall resections for metastatic osteosarcoma of the humerus is reported. In properly selected patients the results of resection of isolated or even multiple pulmonary metastases can be favorable.