William C. Levin

Coexistent Chronic Myelocytic Leukemia, Monoclonal Gammopathy and Multiple Chromosomal Abnormalities*

M ONOCLONAL gammopathy [ 7,2], usually associated with myeloma and primary macroglobulinemia (WaldenstrGm), has also been reported in association with a variety of myeloproliferative disorders, including polycythemia [&9], myelofibrosis [3,8,9], myelofibrosis with myeloid metaplasia (31, osteomyelosclerosis [Will, erythremic myelosis [ 721, erythroleukemia [73], acute myeloblastic or lymphoblastic leukemia [7] and chronic myelocytic leukemia [74-791. Dittmar et al. have reported a biclonal gammopathy in association with polycythemia [20]. We have observed in an adult male subject the coincidence of chronic myelocytic leukemia, monoclonal gammopathy (IgG, type K) and chromosomal abnormalities characterized by several stem lines, one of which exhibited both the Phr chromosome and a chromosomal aberration heretofore observed to be associated with primary macroglobulinemia (WaldenstrBm).

Dysgammaglobulinemic antibody deficiency syndrome

Detailed studies including chromosomal analysis are recorded for two male children withthe dysgammaglobulinemic antibody deficiency syndrome, and previously reported cases of this disorder are reviewed.

UNTREATED CHRONIC MYELOCYTIC LEUKEMIA ASSOCIATED WITH AN UNUSUAL CHROMOSOME PATTERN

Excerpt Reports in the literature of various chromosomal abnormalities associated with leukemias continue to appear (1-9). The subject of this report is a white female patient with chronic myelocyt...

Mild hemophilia affecting both males and females.

SYMPTOMATIC hemophilia in females, with clinical and laboratory data, has been rarely demonstrated, although cases of clinically apparent hemophilia in females who were assumed to be homozygous for...

Production of Specific Antisera against Sickle Cell Anemia Erythrocytes ; Antibody in Sicklemia Sera.

Summary 1. Erythrocytes from 2 individuals with sickle cell anemia, when injected into rabbits, produced antisera which agglutinated erythrocytes of 19 individuals with sickle cell anemia, but not those of 21 individuals with sickle cell trait nor those of 124 normal individuals. 2. Such sera may be useful in the differential diagnosis between sickle cell anemia and sickle cell trait. 3. The presence of agglutinin antibody has been demonstrated in the sera of all of 13 patients with sickle cell anemia. This finding may explain the hemolysis which is characteristic of this disease. 4. Of 11 patients with sickle cell trait, definite agglutinin antibody was demonstrated in the sera of 4, and doubtful agglutinin antibody in 2.

Nuclear Volume Distribution of Phytohemagglutinin-Stimulated Human Lymphocytes

Summary Unstimulated and phytohemagglutinin-stimulated lymphocytes from nine human subjects were suspended in Cetrimide solution before and after tissue culture. Their nuclear volumes were measured serially with a particle counter—400 channel analyzer device. Variations of the volume distribution curves correlated well with the morphological changes associated with blastoid transformation. This method permits rapid and objective assay of lymphocyte transformation.

Blood proteins and their distribution in rats with parabiosis intoxication; determined by paper electrophoresis.

Summary Rats which have developed parabiosis intoxication show, in addition to the other hematologic aberrations which characterize the condition, changes in the blood proteins. Anemic partners have a low plasma protein level and polycythemic animals an elevated plasma protein titre. The partitions which albumin and the respective globulins contribute toward the total serum proteins average the same in both anemic and polycythemic twins, although as compared to control levels there is a diminished serum albumin and an elevated α2-globulin component in each.

The Haemolytic Anaemias

This is volume 3 of the second edition of an encyclopedic treatment of hemolytic disorders. It is unfortunate that volumes 1 and 2 were published seven and five years respectively before volume 3, because the earlier volumes are now incomplete, in light of subsequent developments. Volume 3 considers hemolytic anemias which are secondary or symptomatic in origin. The organization of the material is such that the monograph is presented in three chapters. Chapter 1 (13) deals with hemolytic states associated with Hodgkins disease, leukemia, and other malignancies — particularly those involving the reticuloendothelial structures. Chapter 2 (14) discusses hemolytic disease associated with lupus erythematosus, ulcerative colitis, liver and renal diseases, and the vasculitides in general. Chapter 3 (15) examines hemolytic states associated with a heterogenous group of diseases, including infections, sarcoidosis, pregnancy, hypersplenism, vitamin deficiencies, radiation, hyperoxia, marrow hypoplasia, burns, cardiac surgery, valvular disease of the heart, and march hemoglobinuria.