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Dive into the research topics where William E. Brant is active.

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Featured researches published by William E. Brant.


Annals of Emergency Medicine | 1997

Effect of Oral Contrast Administration for Abdominal Computed Tomography in the Evaluation of Acute Blunt Trauma

Brian D Tsang; Edward A. Panacek; William E. Brant; David H. Wisner

STUDY OBJECTIVE To determine how frequently oral contrast medium (OC) is essential for computed tomography (CT) diagnosis of blunt intraabdominal injury and to quantify the delay associated with OC administration and the incidence of adverse effects. METHODS This retrospective chart review, with prospective reevaluation of CT scans for diagnostic value of OC, took place in a university teaching hospital and Level l trauma center. Participants were blunt-trauma victims admitted between June 1, 1988, and November 1, 1993, who had abdominal CT as part of their initial evaluation. Trauma registry records were used to identify study patients. Available charts and CTs were reviewed for all patients with intestinal/mesenteric and pancreatic injuries. Randomly selected cases of liver injury, spleen injury, and no intraabdominal injury were also reviewed. Blinded CT scans were reevaluated for quality of bowel opacification and value of OC to diagnostic impression. RESULTS During the study period, 2,162 blunt-trauma patients had an abdominal CT; 297 intraabdominal injuries were diagnosed in 248 patients. Full review was done on 124 charts, and 70 CT scans were reevaluated. Thirty-one (100%) of 31 liver and spleen injuries were diagnosed on CT, and OC was considered essential in none of these studies. One (4.5%) of 22 intestinal and mesenteric injuries was seen on CT, but this was the only such injury treated nonoperatively. None of 21 surgically confirmed intestinal/mesenteric injuries was seen on CT. Free air or free OC was seen in none of 7 cases of intestinal perforation. OC was judged essential in none of 20 scans in patients without intraabdominal injury. On 2 scans. OC was considered essential for the radiographic diagnosis. One of these was a normal pancreas at exploration (radiographic false-positive result). The only pancreatic injury requiring specific surgical treatment was missed on CT. Twenty-one percent of patients required placement of nasogastric tube for contrast administration after failing oral administration, and 23% vomited OC. One of 124 had documented aspiration of OC. Average additional time incurred in the ED for administration of OC was 144 minutes. CONCLUSION OC is rarely essential for CT diagnosis of intraabdominal injury. It may improve sensitivity for pancreatic injury, but it does not help identify injuries requiring surgical treatment. Even with OC, CT is insensitive for intestinal injury. Vomiting and aspiration are significant risks. Use of OC adds a significant amount of time to ED evaluation. Adverse effects of OC administration, in this setting, may outweigh its benefits.


Bulletin of The World Health Organization | 2012

Feasibility of using teleradiology to improve tuberculosis screening and case management in a district hospital in Malawi

Rebecca Marie Coulborn; Isabella Panunzi; Saskia Spijker; William E. Brant; Laura Trivino Duran; Cara S. Kosack; Michael Murowa

PROBLEM Malawi has one of the worlds highest rates of human immunodeficiency virus (HIV) infection (10.6%), and southern Malawi, where Thyolo district is located, bears the highest burden in the country (14.5%). Tuberculosis, common among HIV-infected people, requires radiologic diagnosis, yet Malawi has no radiologists in public service. This hinders rapid and accurate diagnosis and increases morbidity and mortality. APPROACH Médecins Sans Frontières, in collaboration with Malawis Ministry of Health, implemented teleradiology in Thyolo district to assist clinical staff in radiologic image interpretation and diagnosis. LOCAL SETTING Thyolo districts 600 000 inhabitants are mostly subsistence-level or migrant farmers living in extreme poverty. Health facilities include one public hospital and 38 primary health centres. Understaffing and the absence of a radiologist make the diagnosis of tuberculosis difficult in a population where this disease affects 66% of patients with HIV infection. RELEVANT CHANGES From September 2010-2011, 159 images (from 158 patients) were reviewed by teleradiology. Teleradiology changed patient management in 36 cases (23.5%). Two (1.3%) of them were cases of pulmonary tuberculosis not previously suspected by clinical staff. In addition, the radiologists review corrected the misdiagnosis of tuberculosis and averted inappropriate treatment in 16 patients (10.5%). LESSONS LEARNT Teleradiology can improve tuberculosis diagnosis and case management, especially if criteria to identify the patients most suitable for referral are developed and the radiologist is conversant with local resources and health problems. Designating a clinical focal point for teleradiology ensures sustainability. Staff need time to adapt to a new teleradiology programme.


Pediatric Radiology | 2011

Paediatric radiology seen from Africa. Part I: providing diagnostic imaging to a young population

Savvas Andronikou; Kieran McHugh; Nuraan Abdurahman; Bryan Khoury; Victor Mngomezulu; William E. Brant; Ian A Cowan; Mignon McCulloch; Nathan Ford

Paediatric radiology requires dedicated equipment, specific precautions related to ionising radiation, and specialist knowledge. Developing countries face difficulties in providing adequate imaging services for children. In many African countries, children represent an increasing proportion of the population, and additional challenges follow from extreme living conditions, poverty, lack of parental care, and exposure to tuberculosis, HIV, pneumonia, diarrhoea and violent trauma. Imaging plays a critical role in the treatment of these children, but is expensive and difficult to provide. The World Health Organisation initiatives, of which the World Health Imaging System for Radiography (WHIS-RAD) unit is one result, needs to expand into other areas such as the provision of maintenance servicing. New initiatives by groups such as Rotary and the World Health Imaging Alliance to install WHIS-RAD units in developing countries and provide digital solutions, need support. Paediatric radiologists are needed to offer their services for reporting, consultation and quality assurance for free by way of teleradiology. Societies for paediatric radiology are needed to focus on providing a volunteer teleradiology reporting group, information on child safety for basic imaging, guidelines for investigations specific to the disease spectrum, and solutions for optimising imaging in children.


Journal of Computer Assisted Tomography | 1989

Computed tomography of duodenal diverticula.

Elwood E. Stone; William E. Brant; Gregory B. Smith

Duodenal diverticula are common and usually considered to be incidental findings. However, they may cause significant patient morbidity due to inflammatory or pressure effects and may be mistaken for pancreatic pathology on CT. We correlated the CT and upper gastrointestinal series appearance of duodenal diverticula in 14 patients, including two patients in whom erroneous diagnoses of pancreatic pseudocyst and pancreatic abscess were suggested based on CT findings. The duodenal diverticulum was visualized on CT in 10 of 14 patients (71%). The CT appearance was variable, with some diverticula containing air, fluid, contrast medium, or a mixture of the three.


Abdominal Imaging | 2003

Limited abdominal MRI in the evaluation of acute right upper quadrant pain.

K. Y. Oh; M. Gilfeather; Anne M. Kennedy; C. Glastonbury; D. Green; William E. Brant; H. C. Yoon

Background: We investigated whether limited abdominal magnetic resonance imaging (MRI) is as effective as transabdominal ultrasound (US) in evaluating patients presenting with acute right upper quadrant pain.Methods: Twenty-four patients underwent evaluation with a limited abdominal MRI using single-shot fast spin-echo sequences and a right upper quadrant US within 24 h. Two MRI and two US readers independently evaluated the images for gallstones, gallbladder wall thickness, pericholecystic fluid, acute cholecystitis, visualization of the common bile duct, and requests for further imaging. US and MRI findings were compared. Surgical pathology was the gold standard.Results: MRI and US demonstrated no statistically significant difference in the diagnosis of gallbladder wall thickening, the presence of gallstones or pericholecystic fluid, or the diagnosis of acute cholecystitis (p > 0.05). The sensitivity of both for acute cholecystitis was 50%, with specificities of 89% and 86% for US and MRI, respectively. US readers more frequently requested additional tests and displayed more variability in whether they could adequately see the common bile duct.Conclusion: Limited MRI is equivalent to US in diagnosing gallstones, gallbladder wall thickening, pericholecystic fluid, and acute cholecystitis in patients presenting with symptoms of acute right upper quadrant pain. Especially in sonographically challenging patients, limited MRI may provide a faster, easier method of diagnosis.


Laryngoscope | 1982

USE OF HIGH RESOLUTION THIN SECTION CT SCANNING OF THE PETROUS BONE IN TEMPORAL BONE ANOMALIES

James E. Olson; Robert H. Dorwart; William E. Brant

High resolution thin section axial CT scans (REVIEWTM reconstruction ARRANGETM reformation — General Electric copyright) were utilized to evaluate the petrous bone of 17 patients, ages 3 to 60, with congenital hearing loss. Two scanning protocols were evaluated: 1.5 mm thick sections at 1.5 mm intervals, and 1.5 mm thick sections at 1.0 mm intervals. These protocols were qualitatively compared with regard to 1. visualization of small anatomical structures, and 2. computer reformatted images in coronal and sagittal planes. Our experience suggests this imaging capability is highly useful in the evaluation of congenital ear abnormalities.


BMC Medical Education | 2011

Participating in a Community of Learners enhances resident perceptions of learning in an e-mentoring program: proof of concept

Timona Obura; William E. Brant; Fiona Miller; I J Parboosingh

BackgroundCommunity learning and e-mentoring, learning methods used in higher education, are not used to any extent in residency education. Yet both have the potential to enhance resident learning and, in the case of community learning, introduce residents to basic lifelong learning skills. We set out to determine whether residents participating in an Internet based e-mentoring program would, with appropriate facilitation, form a community of learners (CoL) and hold regular community meetings. We also determined resident and faculty perceptions of CoL and Internet sessions as effective learning experiences.MethodsA six-month e-mentoring pilot was offered to 10 Radiology residents in the Aga Khan University Postgraduate Medical Education Program in Nairobi, Kenya (AKUHN) with a Professor of Radiology, located at University of Virginia, USA, acting as the e-mentor. Monthly Internet case-based teaching sessions were facilitated by the e-mentor. In addition, residents were coached by a community facilitator to form CoL and collectively work through clinical cases at weekly face-to-face CoL sessions.Event logs described observed resident activity at CoL sessions; exit survey and interviews were used to elicit perceptions of CoL and Internet sessions as effective learning experiences.ResultsResident adoption of CoL behaviors was observed, including self-regulation, peer mentoring and collaborative problem solving. Analysis revealed high resident enthusiasm and value for CoL. Surveys and interviews indicated high levels of acceptance of Internet learning experiences, although there was room for improvement in audio-visual transmission technologies. Faculty indicated there was a need for a larger multi-specialty study.ConclusionsThe pilot demonstrated resident acceptance of community building and collaborative learning as valued learning experiences, addressing one barrier to its formal adoption in residency education curricula. It also highlighted the potential of e-mentoring as a means of expanding faculty and teaching materials in residency programs in developing countries.


Diseases of The Colon & Rectum | 1988

Spontaneous isolated mesenteric fibromatosis. Report of a case.

Mark D. Forte; William E. Brant

A rate case of spontaneous isolated mesenteric fibromatosis (mesenteric desmoid) unassociated with Gardners syndrome or prior abdominal surgery is presented. Computed tomography revealed a nonenhancing, well-defined, large, soft-tissue mass in the mesentery. The clinical and radiographic features of mesenteri fibromatosis are reviewed and the differential diagnosis is discussed.


Journal of Clinical Ultrasound | 1998

Hematocolpos caused by genital bullous lesions in a patient with Stevens‐Johnson syndrome

Miyuki I. Murphy; William E. Brant

We report a case of complete vaginal fusion with subsequent development of hematocolpos in a 14‐year‐old sexually inactive girl previously treated for Stevens‐Johnson syndrome. The epidermal disease was likely precipitated by Mycoplasma pneumoniae pneumonia. The patient presented with lower abdominal cramping and amenorrhea that had persisted for 5 months. Sonography demonstrated a markedly distended vagina filled with echogenic fluid. A diagnosis of hematocolpos secondary to Stevens‐Johnson syndrome was rendered, and the patient underwent surgery with incision of the fused introitus and drainage of about 300 ml of dark blood. While unusual, this case demonstrates that hematocolpos should be considered in patients with a history of epidermal bullous disease and amenorrhea.


Journal of Ultrasound in Medicine | 1991

Sonographic spectrum of fetal cardiac hypoplasia

John P. McGahan; M Choy; M D Parrish; William E. Brant

Four cases of hypoplastic left ventricle and three cases of hypoplastic right ventricle detected sonographically prenatally are presented. A four‐chamber view of the heart was abnormal in all seven cases. The sonographic appearance of the hypoplastic ventricle was variable, being smaller than normal in six of seven cases and not being identified at all in one case. Other ultrasound findings included an atrial septal defect (n = 7); increased size of the contralateral ventricle (n = 6); nonvisualization or poor visualization of the outflow tract of the affected ventricle (n = 6), and intact ventricular septum (n = 5). In one of four cases of hypoplastic left ventricle the pregnancy was terminated; the other three infants died within 5 days after birth. One of the three fetuses with hypoplastic right ventricle was aborted. Of the remaining two infants included one had tricuspid atresia with a ventricular septal defect and one had pulmonary atresia with an intact ventricular septum. Both infants are alive, have had palliative surgery, and will be considered for a more definitive surgical repair. An abnormal four‐chamber view of the heart should alert those performing routine obstetrical ultrasound to a possible hypoplastic ventricle, so that the pregnant woman can be referred to a center capable of performing more sophisticated fetal echocardiography.

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Keri L. London

University of California

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Talissa A. Altes

University of Virginia Health System

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Alan H. Matsumoto

University of Virginia Health System

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