William Fraimow

Pulmonary alveolar proteinosis: A correlation of pathological and physiological findings in a patient followed up with serial biopsies of the lung

Abstract A case of pulmonary alveolar proteinosis followed up with serial biopsies of the lung performed over a two and a half year period is presented. Extensive pulmonary function studies during that period are included, with a correlation of the pathological and physiological findings. The patient at the peak of his illness exhibited marked pulmonary insufficiency due both to alveolar-capillary block and increased venous admixture. The pathological, physiological and roentgenographic findings have shown a marked improvement over a two and a half year period. This has been accompanied by progressive improvement in his clinical status to the point that he is now symptom-free. The ultimate prognosis must remain guarded, however, because of the obscure etiology of the disease and our present lack of knowledge as to its course.

Physiologic and clinical aspects of pulmonary alveolar proteinosis.

Excerpt The recently described disease, pulmonary alveolar proteinosis,1has aroused much clinical and pathologic interest. This disease bears a significant mortality (30%) in the reported cases. De...

Clinical and physiological considerations in pulmonary muscular hyperplasia.

Excerpt The presence of increased amounts of smooth muscle in the lung is not rare, in itself. In most instances, however, localized areas of smooth muscle hyperplasia have been described, associat...

Effect of partial and total cardiopulmonary bypass with whole blood or hemodilution priming on pulmonary surfactant activity

Abstract 1. 1. Minimal surface tension of the lungs of dogs was estimated in terms of surfactant activity before, during, and after cardiopulmonary bypass. 2. 2. Surfactant values of normal lungs sampled before the operation ranged from 1.8–11.8 dynes per cm. 2 , averaging 5.1 dynes per cm. 2 3. 3. Animals perfused one or two hours with 50% hemodilution showed little change in surfactant values immediately after the perfusion was completed. However, in those that survived more than fifteen hours the values rose an average of 11.1 dynes per cm. 2 4. 4. 60% of animals perfused with whole blood for one hour had rises in surface tension (average 8.5 dynes/cm. 2 ) both at the completion of bypass and at the time of death. None of these dogs survived more than eight hours. 5. 5. No rise in minimal surface tension was observed in animals placed on controlled ventilation without cardiopulmonary by pass; only one of 6 animals with thoracotomy and heparin showed a persistent rise. 6. 6. Possible explanations for the temporary protection to lung surface afforded by hemodilution as compared to whole blood perfusion are discussed.

Alterations in Pulmonary Function Following Diagnostic Radiological Procedures.

Excerpt The increasing availability and utilization of diagnostic radiologic techniques in internal medicine make the proper evaluation of their hazards and limitations essential. This paper deals ...