William H. Ridder

The Presence of a Magnocellular Defect Depends on the Type of Dyslexia

Previous studies have identified a magnocellular pathway defect in approximately 75% of dyslexics. Since these experiments have not classified dyslexia into subtypes, the purpose of this experiment was to determine if adult dyseidetic dyslexics or dysphoneidetic dyslexics suffer from a defect in the magnocellular pathway. Nine dyseidetic dyslexics, eight dysphoneidetic dyslexics, and nine normal readers participated in the experiment. Contrast sensitivity functions (CSF) were determined with vertically oriented sine wave gratings (0.5, 1.0, 2.0, 4.0, 8.0, 12.0 c/deg drifting at 1 and 10 Hz) by employing a two-alternative, forced-choice technique. The results of the experiment indicated that dysphoneidetic dyslexics had reduced sensitivity to low spatial frequencies at 10 Hz, whereas dyseidetic dyslexics did not have reduced sensitivity at either 1 or 10 Hz. These results suggest that the type of dyslexia influences whether losses in perception are found which are consistent with a magnocellular deficit.

Contact lens drying and visual performance: the vision cycle with contact lenses.

Background and Purpose. The purpose of this study was to measure the effect of precontact lens tear film break-up on visual performance. Methods. Four asymptomatic soft contact lens wearers had contrast sensitivity measured by a temporal, two-alternative, force choice paradigm combined with a self-paced methods of limits. Stimuli were vertically orientated sine wave gratings (0.5 to 14 cycles per degree [cpd] presented for 16.67 ms. Contrast sensitivity was measured before precontact lens tear break-up by a stimuli presented 2 s after the blink. A post-tear layer break-up measurement taken with the stimuli presented after break-up had been observed by the use of a video camera attached to a Tearscope. Results. Contrast sensitivity was found to be reduced following precontact lens tear film break-up for stimuli of 4, 6, and 10 cpd; the data approached significance at 14 cpd. Further reductions in contrast sensitivity were observed for one subject when measurements were continued for 4 s following break-up. Conclusions. Contrast sensitivity is significantly reduced for middle to high spatial frequencies when the precontact lens tear film dries and breaks up. The combination of observations of visual performance immediately following the blink (from earlier experiments) and measurements following tear film break-up in this experiment allows description of a “vision cycle” for contact lens wearers in the interval between blinks. It is suggested that break-up of the precontact lens tear film could account for the complaints of intermittent blurred vision in some contact lens wearers and may provide a stimulus to blinking in these individuals.

Visual discomfort and objective measures of static accommodation.

Purpose. Accommodation insufficiency and fatigue have been associated with near work visual discomfort symptoms, but clinical measures of accommodation amplitude suggest insufficiency is uncommon and often not weak enough to cause symptoms. However, recent studies show that the clinical push-up test used to measure amplitude overestimates accommodative function. This study uses an open-field autorefractor to measure accommodative stimulus-response functions objectively in college students with and without near work induced discomfort symptoms. Methods. Using a Grand-Seiko WAM 5500 autorefractor, 2 min recordings were made each at five viewing distances (0 to 5 D) to measure an accommodative response function. Visual discomfort symptoms were assessed using the Conlon survey. Results. A strong and positive correlation between accommodative lag and visual discomfort symptoms was found under near work conditions. The prevalence of accommodative insufficiency was much higher than estimated by clinical measures. Conclusions. Accommodative insufficiency and fatigue should be defined and described by objective methods using extended viewing times to assess function.

Not all dyslexics are created equal.

Background. Dyslexia is a common disorder that has traditionally been treated as a homogeneous condition. However, recent evidence indicates that it is a heterogenous condition with several subtypes. For example, studies of the visual system indicate that not all dyslexics have a normal visual pathway. Approximately 75% have a processing deficit in the magnocellular pathway. Our previous study indicated that dysphoneidetic but not dyseidetic dyslexics exhibit a magnocellular pathway defect. Purpose. The purpose of this study was to expand our previous work by also examining dysphonetic dyslexics. Additionally, the stimulus was altered to enhance detection of a magnocellular pathway defect in any dyslexic subtype. Methods. Temporal contrast sensitivity functions were determined with a flickering stimulus (5, 10,15, 20, and 25 Hz) by using a temporal, two-alternative, forced-choice technique. Results. The results indicate that the dyseidetic dyslexics do not have a magnocellular pathway defect, whereas the dysphoneidetics do. Furthermore, examination of the individual dysphonetics indicated that the more severely affected subjects also exhibited a magnocellular pathway defect. Conclusion. These results suggest that treatment strategies for dyslexics may need to be modified to take into account their specific subtype.

All developmental dyslexic subtypes display an elevated motion coherence threshold

Purpose. Psychophysical studies indicate that many dyslexics have a motion-processing deficit. The purpose of this study was to determine whether elevated motion coherence thresholds correlate with the specific dyslexic subtypes as defined by the Boder classification scheme. Methods. Twenty-one dyslexics (seven dyseidetics, six dysphonetics, and eight dysphoneidetics) and 19 age- and gender-matched controls participated in the study. The dyslexics were identified by an exclusionary approach and then subtyped with the Adult Dyslexia Test or the Dyslexia Determination Test. Motion coherence thresholds were determined with random dot kinematograms composed of signal dots and noise dots. Signal dots moved either left or right on each trial, whereas noise dots moved in random directions. The percentage of dots that comprised the signal was varied randomly on each trial (0 to 21% in 3% increments). Subjects guessed the direction of signal dot motion on each trial (two-alternative forced-choice task). A 75% correct threshold was determined with a Weibull equation fit to the psychometric function. Results. All three dyslexic subtypes had elevated motion coherence thresholds (t-test; dyseidetics p = 0.01, dysphonetics p = 0.039, dysphoneidetics p = 0.048). Conclusion. Motion-coherence deficits are not correlated with a specific dyslexic subtype, but, rather, are common to all subtypes. However, some individuals in each of the dyslexic subtypes were found to have normal motion coherence thresholds, suggesting that other factors must be considered to predict the motion sensitivity deficits found in dyslexia.

The visual evoked potential in the mouse Origins and response characteristics

The visual evoked potential (VEP) in the mouse is characterized and compared to responses obtained with the electroretinogram (ERG). The results indicate that: 1, the VEP originates in the visual cortex; 2, the rod and cone pathways contribute separately to the VEP; 3, temporal tuning functions for rod and cone ERGs are low pass and band pass, respectively; VEP tuning functions are both band pass; and 4, VEP acuity is 0.62+/-0.156 cycles/degree. The differences in the spatial and temporal tuning functions obtained from the retina and visual cortex provides a tool to investigate signal processing through the visual system.

Accommodation response and visual discomfort

Although visual discomfort symptoms associated with near work have been correlated with clinical measures of accommodation, studies using objective recordings have not found corresponding deficits in accommodative function. One problem with previous studies is that accommodation measures have been too brief to assess accommodative fatigue. This study examined steady state accommodative responses among a college population with visual discomfort, over a 90‐s time period. Thirty‐one participants were grouped into high (n = 15) or low visual discomfort groups (n = 16) based on their scores on the Conlon Visual Discomfort Survey. Using the WAM‐5500 autorefractor, accommodation responses were recorded at 5 Hz for two consecutive minutes at five viewing distances. The results showed a significant interaction between the high and low discomfort groups over time in accommodation response. The high discomfort group showed an increase in accommodative lag, whereas the low discomfort group had a stable response. Our study suggests that the high visual discomfort group is characterized by accommodative fatigue, with a higher lag of accommodation developing at a near viewing distance over time.

Measuring visual discomfort in college students.

Purpose. The purpose of this study was to measure the distribution visual discomfort symptoms in a group of college students using a survey developed by Conlon et al. and to analyze the type and frequency of symptoms in the subjects who display moderate to high amounts of visual discomfort to ascertain if this condition occurs along a single dimension or consists of different subtypes. Methods. Members of the research team administered a survey of visual discomfort developed by Conlon et al. (Conlon et al., Vis Cogn 1999;6:637–666) to 571 college students at the Claremont Colleges University over a 2-year period. The survey for measuring visual discomfort developed by Conlon consists of 23 items with a four-point scale (0 to 3) (see below). Scores on the survey can range from 0 to 69. Results. A Rasch analysis of the survey results showed that a single symptom dimension accounted for 73.5% of the variance. A principle component analysis of the residual variance from the Rasch analysis yielded three factors: factor 1 was associated with text movement and fading; factor 2 was associated with headache and soreness; and factor 3 was associated primarily with blur and diplopia. Conclusions. The survey developed by Conlon is an appropriate measure of visual discomfort. In addition to the single dimension reported by Conlon, we found that some subjects with moderate to high amounts of visual discomfort tended to report particular types of symptoms. These results suggest that there may be multiple etiologies of visual discomfort.

Effect of artificial tears on visual performance in subjects with dry eye.

Purpose. Disruption of the anterior refracting surface of the eye (i.e., the tear layer) reduces visual performance. Tear layer breakup occurs soon after a blink in contact lens wearers and patients with dry eye. This study determined whether artificial tears stabilize the tear film and improve visual performance in contact lens wearers who also exhibit a dry eye. Methods. Five subjects with mild to moderate dry eye (probably as a result of an evaporative dry eye) during spectacle and contact lens wear were fitted with a Focus Night & Day hydrogel lens for this study. A temporal, two-alternative, forced-choice paradigm was used to measure contrast sensitivity. The stimuli were vertically oriented sine wave gratings (between 0.5 and 14 cpd) presented for 16.67 msec. The stimuli were presented at two different times after blink detection: 2 sec after blink detection (i.e., before tear layer breakup) or 4 sec after tear film breakup. Four conditions were investigated at 4 sec after tear layer breakup: 1) without artificial tears added, 2) with Clerz2 (Alcon, Fort Worth, TX) instilled, 3) with Sensitive Eyes (Bausch & Lomb, Rochester, NY), and 4) with GenTeal (Novartis, Basel, Switzerland) applied. The artificial tears were instilled at 10-min intervals during the data collection. The short-term visual effects of drop instillation were also investigated by continually monitoring contrast sensitivity for a 14-cpd grating after a single-drop administration. Results. High spatial frequency contrast sensitivity and visual acuity were found to be reduced after tear film breakup in the absence of supplementation with artificial tears. For the group data (and four of five subjects), the instillation of Sensitive Eyes improved the contrast sensitivity and visual acuity to the level attained before tear breakup, thus prolonging visual performance. Clerz2 and GenTeal did not produce any enhancement in visual performance. A short-term decrease in contrast sensitivity was also observed with a single administration of Clerz2 and GenTeal. Conclusions. This study indicates that there was a benefit of Bausch & Lomb Sensitive Eyes tear supplementation on visual performance in subjects with an evaporative dry eye. This may be the result of 1) aqueous supplementation in these subjects and/or 2) the minimal tear layer disruption found with Sensitive Eyes drop administration. The results suggest that practitioners need to identify those patients who can benefit from the use of appropriate artificial tear supplements.

Suppression of contrast sensitivity during eyelid blinks

Each blink of the eyelids is associated with a concurrent suppression of vision that lasts as long as 200 msec. Saccadic eye movements are also associated with a concurrent suppression of vision. Previous studies suggested that blink and saccadic suppression may be the result of a single mechanism. Volkmann, Riggs, White and Moore [(1978) Vision Research, 18, 1193-1199] demonstrated that saccadic suppression is most evident for low spatial frequency stimuli. However, the effect of stimulus spatial frequency on blink suppression has not been evaluated. If blink suppression and saccadic suppression result from a single mechanism, then blink suppression should also exhibit its greatest effect at low spatial frequencies. The purpose of this study was to determine the effect of stimulus spatial frequency on blink suppression. The stimulus was a sine-wave grating presented at different times after the blink. Psychometric functions were produced from the data for each post-blink, stimulus onset time and a Weibull function was fit to the data to determine threshold. The magnitude and duration of blink induced contrast sensitivity suppression was found to depend on the spatial frequency of the stimulus employed (similar to saccadic suppression). This is further evidence that a single mechanism may produce both blink induced visual suppression and saccadic suppression.