William M. Mendenhall

Management of T1-T2 Glottic Carcinomas

T1–T2 glottic carcinomas may be treated with conservative surgery or radiotherapy. The goals of treatment are cure and laryngeal voice preservation. The aim of the current study was to review the pertinent literature and discuss the optimal management of early‐stage laryngeal carcinoma. Literature review indicated that the local control, laryngeal preservation, and survival rates of patients were similar after transoral laser resection, open partial laryngectomy, and radiotherapy. Voice quality depended on the extent of resection for patients undergoing surgery; results for patients undergoing laser resection for limited lesions were comparable to the corresponding results for patients receiving radiotherapy, whereas open partial laryngectomy yielded poorer results. Costs were similar for laser resection and radiotherapy, but open partial laryngectomy was more expensive. Patients with well defined lesions suitable for transoral laser excision with a good functional outcome were treated with either laser or radiotherapy. The remaining patients were optimally treated with radiotherapy. Open partial laryngectomy was reserved for patients with locally recurrent tumors. Cancer 2004.

Retroperitoneal soft tissue sarcoma.

The objective of the current study was to define the optimal treatment for patients with retroperitoneal soft tissue sarcomas (RPS). The authors conducted a review of the pertinent literature and found that the majority of patients had locally advanced RPS at the time of diagnosis. Surgery was the mainstay of treatment, and macroscopic total excision was feasible in approximately 50–67% of patients. The 5‐year probability of local control was approximately 50%, and the likelihood of developing distant metastasis was approximately 20–30%. The 5‐year survival rate was approximately 50%, and deaths due to recurrent RPS continued to occur after 5 years. Postoperative radiotherapy (RT) decreased the likelihood of local recurrence, although it demonstrated no impact on survival. Adjuvant chemotherapy had no proven efficacy. The factor that was found to have the greatest impact on the prognosis for patients with RPS was the ability to achieve a macroscopic total resection. The authors concluded that RPS usually is advanced at the time of diagnosis. The optimal treatment was complete resection. Most patients experienced recurrent disease after surgery, and the most common site of failure was local. Adjuvant RT reduced the risk of local recurrence, but its impact on survival was questionable. Cancer 2005.

Radiotherapy alone or combined with surgery for salivary gland carcinoma.

The authors analyzed the outcomes of patients treated with radiotherapy (RT) alone or combined with surgery for carcinoma of the salivary glands.

Preoperative Treatment of Patients with Locally Advanced Unresectable Rectal Adenocarcinoma Utilizing Continuous Chronobiologically Shaped 5- Fluorouracil Infusion and Radiation Therapy

This study was designed to determine the efficacy and maximally tolerated dose of 5‐fluorouracil when administered by chronobiologically shaped prolonged infusion in combination with radiation therapy in patients with both locally advanced and unresectable rectal carcinoma.

Follicular thyroid carcinoma: prognostic factors and the role of radioiodine.

The objective of this study was to investigate the patterns of recurrence, various prognostic factors, and the role of radioiodine in the treatment of patients with follicular thyroid carcinoma (FTC).

Radiotherapy alone or after subtotal resection for benign skull base meningiomas.

The objective of the current study was to analyze the long‐term local control and complications in a series of patients who were treated with radiotherapy for benign skull base meningiomas.

Merkel cell carcinoma: treatment and outcomes.

The purpose of the current study was to determine the outcomes of patients with previously untreated Merkel cell carcinoma of the skin who were treated with curative intent.

Impact of radiographic findings on prognosis for skin carcinoma with clinical perineural invasion

The objective of the current study was to correlate pretreatment computed tomography and magnetic resonance imaging studies with outcomes for patients with squamous or basal cell carcinoma of the skin and clinical perineural invasion.

Elective inguinal lymph node irradiation for pelvic carcinomas the university of florida experience

Background. There is little published information pertaining to elective inguinal lymph node irradiation for carcinomas originating in the pelvis that place the inguinal lymph nodes at risk.

Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery

Treatment outcomes were analyzed for retromolar trigone squamous cell carcinoma.