William P. Paaske
University of Copenhagen
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Featured researches published by William P. Paaske.
Microvascular Research | 1983
William P. Paaske
The transcapillary exchange of albumin was examined in seven rabbits using plasma disappearance curves and black box kinetic analysis. From the experimental data and the Renkin and Kedem-Katchalsky equations it was found that the average whole body diffusional capillary permeability coefficient for albumin was 24 X 10(-8) cm/sec as the total whole body capillary permeability-surface area product was 0.0739 ml/100 g X min (surface area estimate 50 cm2/g). The convective components of the net albumin tracer flux was found to be 15%, and the pure permeation ratio of influx to outflux (R = 0.61) of systemic albumin was reduced to 0.57. The solvent drag component of either unidirectional flux relative to the permeative component was 0.037. The Casley-Smith hypothesis of solvent drag convection up a gradient across the capillary membrane could not be verified as possible. It is emphasized that the so-called transcapillary escape rate is an arbitrary rate constant which cannot be attributed to reflect any physiological process, especially not the transcapillary exchange of albumin.
Journal of Vascular Surgery | 1988
William P. Paaske; Per Bagl; Jørgen E. Lorentzen; Klaus Olgaard
A 75-year-old man developed acute, fulminating compartment syndrome of the femoral and crural muscles together with acute toxic nephropathy caused by severe myoglobinemia after uncomplicated embolectomy of the common femoral artery. In addition to fasciotomies and administration of mannitol, sodium hydrogen bicarbonate, and furosemide, we performed plasma exchanges on three occasions. The urine and serum concentrations of myoglobin fell from above 180.0 and 50.0 mg/dl, respectively, to 0.14 and 0.11 mg/dl after the third plasma exchange on the ninth day after admission. The serum creatinine concentration was normal on admission, peaked at 2.85 mg/dl, and returned to normal values at discharge. We suggest that plasma exchange may be considered an adjunct to conventional therapy of compartment syndrome with associated acute toxic nephropathy caused by myoglobinemia.
Acta Physiologica Scandinavica | 1973
Ole Henriksen; Steen Levin Nielsen; William P. Paaske; Per Sejrsen
Acta Physiologica Scandinavica | 1977
William P. Paaske
Acta Physiologica Scandinavica | 1973
Ole Henriksen; Steen Levin Nielsen; William P. Paaske
Acta Physiologica Scandinavica | 1977
William P. Paaske; Per Sejrsen
Acta Physiologica Scandinavica | 1981
Per Sejrsen; Ole Henriksen; William P. Paaske
Microvascular Research | 1985
Per Sejrsen; William P. Paaske; Ole Henriksen
Acta Physiologica Scandinavica | 1977
William P. Paaske
Acta Physiologica Scandinavica | 1980
Stig Haunsø; William P. Paaske; Per Sejrsen; Ole Amtorp