William S. Murray

Ovarian Secretion and Tumor Incidence

(1) Non-breeding reduces tumor incidence in mice and delays the time of tumor appearance (207 mice used). (2) Two hundred and ten female mice castrated at 28-35 days behave much the same as non-breeding females. (3) Two hundred and forty-one males castrated at 28-35 days did not develop tumor, thus resembling non-castrated males. (4) Spontaneous tumors, never obtained in thousands of normal males of the stock used, may develop in castrated males which have received subcutaneous transplants of ovarian tissue (210 operated—four tumors).

The Genetics of Non-Epithelial Tumor Formation in Mice

THE present communication represents a condensed summary of a series of experiments on the genetics of the tendency to produce non-epithelial tumors in mice. A total of 343 such tumors occurring spontaneously in two inbred strains of mice and their hybrids is included in the recorded data. Each tumor has been examined and identified histologically. In one of the parent inbred strains C57 black there were 121 such tumors. In the other dba, dilute brown there were 23. In the C57 black stock the tumors may be tabulated as in Table 1. TAXBlE 1