William W. Budd

Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. I. Local cerebral blood flow and glucose utilization.

Diffuse cerebral ischemia was created in pentobarbital-anesthetized cats by basllar and bilateral carotid artery occlusions and hypotension. Local cerebral blood flow (1CBF) was assessed autoradiographically with 14C-antipyrine, and local cerebral glucose utilization with 14C-2-deoxyglucose. In animals without glucose pretreatment, 15 min of ischemia led to a homogeneous reduction of post-ischemic cerebral perfusion to 31% of control; ischemia of 30 min produced post-ischemic perfusion heterogeneities in the cerebral cortex and deep gray structures. In animals pretreated with dextrose, 1.5 gm/kg intrarenously, heterogeneous cerebral perfusion was observed following only 15 min of ischemia, and a severe global impairment of cerebral reperfusion occurred after the 30 min insult. Deoxyglucose autoradiograms in the latter animals were remarkable for a complete suppression of tracer uptake in the cerebral cortex and a paradoxically increased tracer concentration in the cerebral white matter. Mean plasma glucose in the treated animals exceeded 1000 mg/100 ml. Large glucose loads prior to ischemia dramatically Impair post-ischemic cerebral perfusion.

Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels.

Glucose was Infused intravenously into cats prior to cerebral ischemia. Brain concentrations of glucose, measured in 7 regions, were elevated 2.5-fold compared to those of non-infused animals. Ischemia of 15 or 30 minutes duration caused a greater accumulation of lactic add in the brain of glucose-infused animals. Post-iscbemic restitution of cerebral ATP, phospbocreatine, and lactate during 90 minutes of reclrculation was severely impaired in the brain of animals pretreated with glucose compared to untreated animals. Thus, excess lactic addosis may be a major factor interfering with metabolic restitution following cerebral ischemia.

Stream corridor management in the Pacific Northwest: I. Determination of stream-corridor widths

King County, Washington is a part of the rapidly growing Pacific Northwest region. This growth has placed pressure on stream corridors. Past studies about regional stream corridors provide a rich source of information for environmental planners and managers. This article draws on existing literature and case studies to provide guidelines for determining optimal stream corridor widths in a watershed located in King County, Washington.

Resilience and sustainability in US urban areas

The relationship between the level of resilience and the level of sustainability plans and policies found in 40 American urban areas is examined. The resilience index reflects motivation, capacity and information; sustainability plans and policies are measured by a content analysis of city documents. The results show that: the presence of sustainability plans and policies is related to resilience, but not to aggregate measures of diversity, formal education or proportion of persons living in poverty; resilience has a significant impact on sustainability plans and policies even when controlling for diversity, education, poverty, and inequality; resilience is more likely to be present in a communitarian political culture; and resilience retains its impact on sustainability plans and policies even when controlling for type of political culture.

Perceptions, fear, and economic loss: an application of prospect theory to environmental decision making

Most of the analysis of costs associated with the introduction of risky prospects has concerned contingent costs amenable to insurance programs. An important missing element is the current cost associated with changes in uncertainty. These costs are not amenable to insurance plans and require compensation in order to prevent transfers. In a novel approach, this paper develops an application of prospect theory to such questions, in an intergenerational context. The importance of such an application is demonstrated in a case study of the high-level nuclear waste repository (HNWR) siting decision. As a case study, the costliness of obtaining some elements of the analysis leads to a simulation approach, comparing prospect costs at the three sites that were under consideration by the U.S. Department of Energy. Finding that such costs can be large, we argue for a reassessment of current risk analysis approaches. On a policy note, on the basis of the prospect cost analysis here, the choice of the Yucca Mountain, Nevada, HNWR site seems ill-advised.

Toward a Preventive Environmental Education Curriculum: The Washington State University Experience

Abstract There is a current movement toward preventive approaches in U.S. environmental regulations and environmental management. The development and the effectiveness after 1 year of a university course in pollution prevention are discussed. The aspects of a collaborative, interdisciplinary, and applied curriculum are highlighted. Evaluations by students, instructors, and university facility managers provide evidence that the course is an effective model for educating students and businesses.

Use of the environmentally sensitive areas rule by county governments in Washington State

Abstract The Washington SEPA empowers local governments with the responsibility of reviewing otherwise exempt proposals which could affect important natural resources. Most county governments have not used the ESA system, but reasons have varied from counties which have legal review systems in place, and for which non-use of the SEPA provision is a technicality, to counties which simply do not recognize ESAs. Most counties recognize some important fragile resources, and in one form or another attempt to influence land uses which could diminish those resources or cause public harm. The question remains as to whether the review process in each county includes a comprehensive approach to “… places with unstable soils, steep slopes, unusual or unique plants or animals, wetlands, or areas which lie within floodplains” (WAC 197-11-908). Additionally, it is unclear if local governments are adequately maintaining natural resources within their jurisdictions in the public interest by using the current planning strategy. This study shows that a county level environmental review process for sensitive natural resources in Washington is highly inconsistent among counties in choice of resources for review consideration and in criteria used to define resources. A uniform statewide approach toward ESAs may be appropriate for resources such as wetlands and critical wildlife habitats which require ecologically consistent regional management.

Stream corridor management in the Pacific Northwest: II. Management strategies

King County, Washington is part of the rapidly growing Pacific Northwest region. Analysis of past and current federal, state, and county regulations and administation reveals how stream corridors have been protected to date. This article draws on scientific literature and a case study to suggest future management strategies and guidelines for controlling development in King County watersheds.

Assimilative capacity and water resource management: Four examples from the United States

Abstract The concept of environmental thresholds has been advocated as a means of assessing the assimilative capacity of an ecosystem to withstand human intervention. Use of the environmental threshold concept in various environmental management processes and techniques is generally founded on the concepts theoretical message of “limitedness”, providing an essential framework for the subsequent design of appropriate environmental standards and land-use regulations. The experience of four regions in the U.S.A. with the application of the threshold concept in water resource management is analyzed. The four case study regions include: the New Jersey Pinelands, the Lake Tahoe Basin of Nevada and California, the Texas Edwards Aquifer, and the Spokane-Rathdrum Aquifer of Washington and Idaho.

Trajectory analysis of acid deposition data from the New Jersey pine barrens

Abstract This research provides an example of the application of a simple method for evaluating regional interrelationships using air parcel trajectory analysis. An assessment of trajectories associated with storms affecting McDonalds Branch watershed (39°50′N, 74°30′W) is presented. A simple classification system is used to examine regional contributions of acid precursors. The results of the work suggest that major regional sources of acid precursor emissions dominated precipitation acidity for the Pine Barrens region from 1978 to 1981. An incremental approach to acid precipitation policy is suggested.