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Dive into the research topics where Winfried Albert is active.

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Featured researches published by Winfried Albert.


Molecular Cancer Research | 2009

Large-Scale Production and Characterization of Novel CD4+ Cytotoxic T Cells with Broad Tumor Specificity for Immunotherapy

Claudia Jursik; Michaela Prchal; Regina Grillari-Voglauer; Karel Drbal; Elke Fuertbauer; Herbert Jungfer; Winfried Albert; Eva Steinhuber; Thomas Hemetsberger; Johannes Grillari; Hannes Stockinger; Hermann Katinger

Immune-cell–based approaches using cytotoxic and dendritic cells are under constant scrutiny to design novel therapies for the treatment of tumors. These strategies are hampered by the lack of efficient and economical large-scale production methods for effector cells. Here we describe the propagation of large amounts of a unique population of CD4+ cytotoxic T cells, which we termed tumor killer T cells (TKTC), because of their potent and broad antitumor cell activity. With this cultivation strategy, TKTCs from peripheral blood mononuclear cells are generated within a short period of time using a pulse with a stimulating cell line followed by continuous growth in serum-free medium supplemented with a mixture of interleukin-2 and cyclosporin A. Expression and functional profiling did not allow a classification of TKTCs to any thus far defined subtype of T cells. Cytotoxic assays showed that TKTCs kill a panel of tumor targets of diverse tissue origin while leaving normal cells unaffected. Blocking experiments revealed that TKTC killing was, to a significant extent, mediated by tumor necrosis factor-related apoptosis-inducing ligand and was independent of MHC restriction. These results suggest that TKTCs have a high potential as a novel tool in the adoptive immunotherapy of cancer. (Mol Cancer Res 2009;7(3):339–53)


Archive | 1986

Process for the quantification of cell populations or subpopulations and a reagent suitable therefor

Hartmut Schetters; Josef Endl; Winfried Albert


Archive | 1982

Creatinine specific antibody

Joachim Siedel; Ulrich Neumann; Joachim Ziegenhorn; Hans-George Batz; Helmut Lenz; Brigitte Pautz; Winfried Albert


Archive | 1978

Polyamide-fixed biologically active protein

Jurgen Horn; Winfried Albert; Hans-Georg Dr Rer Nat Batz; Michael Nelbock-Hochstetter


Archive | 1981

Method for enzyme immuno-determinations in heterogeneous phase

George R. Dr. Evanega; Winfried Albert


Archive | 1982

Process and reagent for the determination of creatinine

Winfried Albert; Joachim Ziegenhorn; Joachim Siedel; Hans-Georg Dr Rer Nat Batz; Helmut Lenz; Brigitte Pautz


Archive | 1980

Process for the recovery of α-2-SB-glycoprotein

Walter Eberle; Winfried Albert


Archive | 1996

Autoreactive peptides from human glutamic acid-decarboxylase (gad)

Josef Endl; Peter Stahl; Winfried Albert; Dolores J. Prof. Dr. Schendel; Christian Boitard; Peter van Endert; Günther-Gerhard Prof. Dr. Jung


Archive | 1986

Process for determining the binding capacity of thyroxin-binding globulin

Brigitte Draeger; Winfried Albert; Martina Junius; Jurgen Rasch


Archive | 1990

Process for the production of permanently culturable animal and human cell lines and the use thereof

Herbert Jungfer; Heinrich Barchet; Winfried Albert

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