Winfried Albert
Roche Diagnostics
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Publication
Featured researches published by Winfried Albert.
Molecular Cancer Research | 2009
Claudia Jursik; Michaela Prchal; Regina Grillari-Voglauer; Karel Drbal; Elke Fuertbauer; Herbert Jungfer; Winfried Albert; Eva Steinhuber; Thomas Hemetsberger; Johannes Grillari; Hannes Stockinger; Hermann Katinger
Immune-cell–based approaches using cytotoxic and dendritic cells are under constant scrutiny to design novel therapies for the treatment of tumors. These strategies are hampered by the lack of efficient and economical large-scale production methods for effector cells. Here we describe the propagation of large amounts of a unique population of CD4+ cytotoxic T cells, which we termed tumor killer T cells (TKTC), because of their potent and broad antitumor cell activity. With this cultivation strategy, TKTCs from peripheral blood mononuclear cells are generated within a short period of time using a pulse with a stimulating cell line followed by continuous growth in serum-free medium supplemented with a mixture of interleukin-2 and cyclosporin A. Expression and functional profiling did not allow a classification of TKTCs to any thus far defined subtype of T cells. Cytotoxic assays showed that TKTCs kill a panel of tumor targets of diverse tissue origin while leaving normal cells unaffected. Blocking experiments revealed that TKTC killing was, to a significant extent, mediated by tumor necrosis factor-related apoptosis-inducing ligand and was independent of MHC restriction. These results suggest that TKTCs have a high potential as a novel tool in the adoptive immunotherapy of cancer. (Mol Cancer Res 2009;7(3):339–53)
Archive | 1986
Hartmut Schetters; Josef Endl; Winfried Albert
Archive | 1982
Joachim Siedel; Ulrich Neumann; Joachim Ziegenhorn; Hans-George Batz; Helmut Lenz; Brigitte Pautz; Winfried Albert
Archive | 1978
Jurgen Horn; Winfried Albert; Hans-Georg Dr Rer Nat Batz; Michael Nelbock-Hochstetter
Archive | 1981
George R. Dr. Evanega; Winfried Albert
Archive | 1982
Winfried Albert; Joachim Ziegenhorn; Joachim Siedel; Hans-Georg Dr Rer Nat Batz; Helmut Lenz; Brigitte Pautz
Archive | 1980
Walter Eberle; Winfried Albert
Archive | 1996
Josef Endl; Peter Stahl; Winfried Albert; Dolores J. Prof. Dr. Schendel; Christian Boitard; Peter van Endert; Günther-Gerhard Prof. Dr. Jung
Archive | 1986
Brigitte Draeger; Winfried Albert; Martina Junius; Jurgen Rasch
Archive | 1990
Herbert Jungfer; Heinrich Barchet; Winfried Albert