Wing Kin Sze

Survival outcome of patients with nasopharyngeal carcinoma with first local failure: A study by the Hong Kong nasopharyngeal carcinoma study group

The purpose of this article is to report the overall survival (OS) outcome of patients with nasopharyngeal carcinoma (NPC) with local failure who received salvage treatment and to identify prognostic factors for OS.

The evolution of psychological distress trajectories in women diagnosed with advanced breast cancer: a longitudinal study

Anxiety and depression (distress) over the first year following the initial adjuvant therapy for advanced breast cancer (ABC) remain poorly documented in non‐Caucasian populations. This study describes trajectories of distress and their determinants in Chinese women with ABC.

Supportive care needs in Hong Kong Chinese women confronting advanced breast cancer

Women with advanced breast cancer (ABC) are living longer, so understanding their needs becomes important. This cross‐sectional study investigated the type and extent of unmet supportive care needs in Hong Kong Chinese women with advanced breast cancer.

Goal adjustment influence on psychological well-being following advanced breast cancer diagnosis

A diagnosis of advanced breast cancer (ABC) challenges a womans ambitions. This longitudinal study explored (1) if goal adjustment disposition influenced psychological adjustment patterns among women with ABC and (2) if dispositional hope and optimism moderate effects of goal adjustment on psychological adjustment.

Primary yolk sac tumour of the urinary bladder: A case report and review of the literature

We present a case of rare primary yolk sac tumour of the urinary bladder in adulthood. A 31-year-old female patient presented with a history of chronic ketamine abuse, which has not previously been shown to be associated with malignancy development. The final diagnosis was established only after radical cystectomy. A computed tomography (CT) scan showed paraaortic lymph node metastasis. The patient was treated with systemic chemotherapy. A review of the literature revealed that surgical excision and cisplatin-based chemotherapy remain to be the standard of care for extragonadal yolk sac tumours.

Comparing the meanings of living with advanced breast cancer between women resilient to distress and women with persistent distress: a qualitative study

Most women with advanced breast cancer (ABC) show little distress, but about one in ten show persistent distress over time. It remains unclear if meanings ascribed by patients to ABC differentiate these distress trajectories.

Psychometric assessment of the Chinese version of the brief illness perception questionnaire in breast cancer survivors

Objective The eight-item Brief Illness Perception Questionnaire (B-IPQ) supposedly evaluates cognitive and emotional representations of illness. This study examined the validity and reliability of a traditional Chinese version of the B-IPQ in Hong Kong Chinese breast cancer survivors. Methods 358 Chinese breast cancer survivors who had recently ended their primary treatment completed this B-IPQ Chinese version. Confirmatory factor analysis (CFA) tested the factor structure. The internal consistency, construct, predictive and convergent validities of the scale were assessed. Results CFA revealed that the original three-factor (cognitive-emotional representations and illness comprehensibility) structure of the B-IPQ poorly fitted our sample. After deleting one item measuring illness coherence, seven-item gave an optimal two-factor (cognitive-emotional representations) structure for the B-IPQ (B-IPQ-7). Cronbach’s alpha for the two subscales were 0.653 and 0.821, and for the overall seven-item scale of B-IPQ was 0.783. Correlations of illness perception and physical symptom distress, anxiety, depression and known-group comparison between different treatment status suggested acceptable construct validity. The association between baseline illness perception and psychological distress at 3-month follow up supported predictive validity. Conclusions B-IPQ-7 appears to be a moderately valid measure of illness perception in cancer population, potentially useful for assessing illness representations in Chinese women with breast cancer.

Illness perceptions as predictors of psychological distress among head and neck cancer survivors: a longitudinal study

Leventhals commonsense model implies illness perceptions influence illness outcomes. This study examined illness perceptions among head and neck cancer survivors, and whether these predicted subsequent psychological distress.

PO-0698: Clinical outcomes of 4D CBCT-guided stereotactic body radiotherapy for inoperable hepatocellular carcinomas

Purpose/Objective: In this retrospective study, nextgeneration exomic sequencing (NGS) was utilized in biliary and pancreatic adenocarcinoma samples to identify potential novel therapeutic targets that are not routinely assayed in the clinical setting. Materials and Methods: Patients with confirmed pancreatic adenocarcinoma or cholangiocarcinoma were selected based on availability of tissues. A total of 236 somatic genes were surveyed in this review, including 3,230 exons and 47 introns at >900x mapping coverage. NGS reports were generated from 2011 to 2013 and reviewed restrospectively. Statistical analysis was performed using univariate analysis and KaplanMeier survival estimates. Results: Seventeen (95%) of cases harbored at least one potentially actionable mutation, including BRACA (10.5%), CDKN2 (26.3%), FGFR (15.8%), KRAS (42.1%), MLL (26.3%), NRAS (5.3%), PIK3CA (10.5%), and TP53 (42.1%). Notably, KRAS mutations were found at a higher frequency in pancreatic adenocarcinomas in comparison to cholangiocarcinomas (87.5% vs 9.1%). Overall, the most frequent genomic alterations were found within KRAS (42.1%), TP53 (42.1%), CDKN2 (26.3%), and MLL (26.3%). All patients with SMAD alterations were also found to have concurrent KRAS mutations, which is consistent with reported literature. KRAS mutations most commonly involved codon 12, while the locations of SMAD and Tp53 mutations were heterogeneous. In addition, concurrent mutations were found within genes that have been shown to potentially modulate or interact with KRAS-mediated signaling pathways, including CCND3, CDKN2A/B, and RB1. Alterations of BCOR, CCND3, CRKL, NF1, STK11, and TSC1 were rare events (<6%). Furthermore, 95% of patients had multiple, novel mutations that have not been associated with pancreatic or biliary adenocarcinoma. The majority (63.2%) of patients had greater than five mutations identified. Median survival and 5yr OS in pancreatic adenocarcinoma were 30.1 months and 41%, respectively. 5-yr OS in cholangiocarcinoma cases was substantially higher (85.7%), and 27.2% of these patients received EBRT as a component of their treatment. For either subset of patients, there was no significant correlation between number of mutations and OS. Overall, 63% of patients were found to have mutations associated with targeted therapies. One quarter of these patients possessed multiple, concurrent molecular targets for which FDAapproved chemotherapeutic agents are currently available. Conclusions: Novel mutations were identified in the majority of patients, including mutations within a number of genes which have the potential to influence KRAS-mediated signaling, as well as other prominent signaling pathways. These results could potentially serve to identify targets for novel chemotherapeutic agents and to guide personalized, combinatorial therapy in appropriately selected patients. PO-0697 Comparative study failure model esophageal carcinoma with elective nodal regional and involved field irradiation S. Zhu, W. Shen, Z. Liu, J. Li, J. Su Fourth Hospital of Hebei Medical University, Department of Radiation Oncology, Sijiazhuang Hebei, China

Trajectory patterns of supportive care needs among Chinese women with advanced breast cancer

Nadine Köhle 1, Constance Drossaert2, Cornelia van Uden-Kraan3, Irma Verdonck -de Leeuw4, Ernst Bohlmeijer5 1University of Twente, Enschede, Overijssel, The Netherlands, 2University of Twente, Enschede, Overijssel, The Netherlands, 3VU University, Amsterdam, Noord-Holland, The Netherlands, 4VU University, Amsterdam, Noord-Holland, The Netherlands, 5University of Twente, Enschede, Overijssel, The NetherlandsFrom Vision to Action - Innovation and Implementation of an Integrated Cancer Rehabilitation Within Clinical Practice