Winston Thomas
Genentech
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Human Genetics | 1997
Takehisa Matsumoto; Osamu Imamura; Yukako Yamabe; Junro Kuromitsu; Yoshiki Tokutake; Akira Shimamoto; Noriyuki Suzuki; Misako Satoh; Saori Kitao; Koji Ichikawa; Hiroshi Kataoka; Kahori Sugawara; Winston Thomas; Brian Mason; Zenta Tsuchihashi; Dennis Drayna; Minoru Sugawara; Masanobu Sugimoto; Yasuhiro Furuichi; Makoto Goto
Abstract The correlation between mutations in the Werner’s syndrome (WRN) gene and the haplotypes of surrounding markers was studied in Japanese patients. We have elucidated the genomic structure of WRN helicase, and found five additional mutations, designated mutations 6–10. Mutations 4 and 6 were found to be the two major mutations in this population; these mutations comprised 50.8% and 17.5%, respectively, of the total in a sample of 126 apparently unrelated chromosomes. Almost all the patients homozygous for mutation 4 shared a haplotype around the WRN gene, consistent with the view that they are derived from a single ancestor. This important advantage demonstrated in the identification of the WRN gene suggests that the Japanese present a unique population for the cloning of other disease genes. The conserved haplotype was observed across 19 loci, extending a distance estimated to be more than 1.4 Mbp around the WRN gene. This haplotype is rare among random Japanese individuals. Unexpectedly, all the nine patients homozygous for mutation 6 shared a haplotype that was identical to this haplotype at 18 of these 19 markers. These results suggest that mutations 4 and 6 arose independently in almost identical rare haplotypes. The remaining mutations (1, 5, 7, 8, 9, and 10) occurred rarely, and were each associated with different haplotypes.
Genomics | 1993
Winston Thomas; Mark Rubenstein; Makoto Goto; Dennis Drayna
Archive | 1996
Dennis Drayna; John N. Feder; Andreas Gnirke; Bruce E. San Mateo Kimmel; Winston Thomas; Roger K. Wolff
Archive | 1996
John N. Feder; Gregory S. Kronmal; Peter M. Lauer; David A. Ruddy; Winston Thomas; Zenta Tsuchihashi; Roger K. Wolff
Archive | 1996
Zenta Tsuchihashi; Andreas Gnirke; Winston Thomas; Dennis Drayna; David A. Ruddy; Roger K. Wolff; John N. Feder
Human Molecular Genetics | 1993
Winston Thomas; Dennis Drayna
Human Molecular Genetics | 1992
Winston Thomas; Dennis Drayna
Archive | 1996
Dennis Drayna; John N. Feder; Andreas Gnirke; Bruce E. San Mateo Kimmel; Winston Thomas; Roger K. Wolff
DNA Research | 1998
Koji Ichikawa; Akira Shimamoto; Osamu Imamura; Yoshiki Tokutake; Yukako Yamabe; Saori Kitao; Noriyuki Suzuki; Kahori Sugawara; Takehisa Matsumoto; Winston Thomas; Dennis Drayna; Makoto Goto; Masanobu Sugimoto; Minoru Sugawara; Yasuhiro Furuichi
Archive | 1997
John N. San Carlos Feder; Gregory S. Kronmal; Peter M. Lauer; David A. Ruddy; Winston Thomas; Zenta Tsuchihashi; Roger K. Wolff