Winthrope R. Hubler

Tumour angiogenic factor associated with subcutaneous lymphoma

Growth and survival of cutaneous neoplasms are dependent on the development of a nutrient‐supply ing vascular lifeline. A subcutaneous lymphoma is described which mimicked a vascular neoplasm because of the extensive telangiectasia overlying the tumour. Fragments of the lymphoma inserted in direct apposition to the hamster cheek pouch membrane or separated from the membrane by a microporous filter both induced dramatic neovascularization. Control materials failed to induce significant vascular changes. A diffusablc Tumour Angiogenic Factor may play a vital role in tumour survival and portends a therapeutic potential.