Wojciech Kaźmierczak

Expression of metalloproteinases 2 and 9 and tissue inhibitors 1 and 2 as predictors of lymph node metastases in oropharyngeal squamous cell carcinoma.

The matrix metalloproteinases (MMPs) and their tissue inhibitor of metalloproteinases (TIMPs) can decompose extracellular matrix (ECM) components and brake down basement membranes and, thus, promote tumor local invasion and metastasis.

Clinical outcome and patient satisfaction using biodegradable (NasoPore) and non-biodegradable packing, a double-blind, prospective, randomized study ☆

INTRODUCTION Nasal packing after endoscopic sinus surgery is used as a standard procedure. The optimum solution to minimize or eliminate all disadvantages of this procedure may be accomplished using biodegradable packs. OBJECTIVE The aim of this study was to compare patient satisfaction and clinical outcome associated with absorbable and non-absorbable packing after FESS. METHODS In total, 50 patients were included in a prospective, double-blind, randomized trial. One side was packed with polyurethane foam, while the opposite side was packed with gauze packing. On the 2nd, 10th, and 30th postoperative day, the patients were questioned with the aid of a visual analog scale. The standardized questionnaires for bleeding, nasal breathing, feeling of pressure, and headache were used. The presence of synechiae, infection, or granulation was noted and recorded with the video-endoscopy. RESULTS A significant difference according to lower pressure was found in the NasoPore group compared to the controls on day ten after surgery. The NasoPore packing had lower scores with respect to postoperative nose blockage on the 2nd and 10th days. Mucosal healing was better for the NasoPore group, both at day ten and 30 compared with the control group. CONCLUSION The overall patient comfort is higher when using NasoPore compared to non-resorbable traditional impregnated gauze packing. Intensive saline douches applied three to four times per day are mandatory after the operation to prevent synechiae formation and fluid resorption by the packing.

Rare benign pleomorphic adenoma of the nose: short study and literature review.

Pleomorphic adenoma is one of the most common benign tumors of the major salivary glands. It can also occur in the minor salivary glands, which exist in the nasal cavity. Intranasal pleomorphic adenoma usually originates from glands of the nasal septum mucosa. We present the results of endoscopic endonasal surgery of this pathology. The aim of the study was to present the endoscopic technique for nasal septum pleomorphic adenoma surgery. The retrospective examination of 3 patients was performed. There were 2 women and 1 man. Age ranged from 15 to 46 years. All the patients presented with nasal obstruction and occasional epistaxis for at least for 6 months. We performed endoscopic surgery to remove the tumors. In all cases we dissected the septal perichondrium to achieved free margins of the tumor. The microscopic examination revealed an epithelial and myoepithelial component with tubular structures composed of two cell layers, ducts, and a solid area found in a loose myxochondroid area. Additionally, immunohistochemical staining was performed using antibodies against cytokeratin, Ki-67, and vimentin. Patients’ postoperative course was uneventful, and no complications were encountered. No recurrence was present during patients’ postoperative visits. Nasal benign pleomorphic adenoma is a rare tumor which should be taken into consideration in the nasal cavity during surgery. The correct histological diagnosis can be confirmed by additional histological studies. Endoscopic endonasal surgery is reserved for small tumors.

Zespół cichej zatoki u dziecka

Summary Introduction Silent sinus syndrome (SSS) is rare clinical entity described in ophthalmology and otolaryngology literature. It is characterized by spontaneous and progressive enophthalmos and hypoglobus caused by maxillary collapse in the setting of chronic maxillary sinus hypoventilation. The authors report an unusual case of SSS in child. Material and methods A 15 year old boy presented with 6 months history of developing of right cheek deformity with no clinically signs and symptoms of chronic rhinosinusitis. According to nasal endoscopy and CT and NMR scans the silent sinus syndrome was recognized. What is the most important, the deformity of anterior maxillary wall was the main problem and complaint. The patient underwent surgical endoscopic uncinectomy with medial antrostomy. Results The performed treatment successfully corrected both the cheek and the upper eyelid sulcus deformity. The control CT scans performed 3 months after surgery showed normal sinus ventilation with wide medial antrostomy. Conclusions Silent sinus syndrome in a child is characterized by more active resorption and remodeling of anterior maxillary wall with clinically visible deformity. The goal of the treatment is restoration of normal maxillary sinus aeration and this guaranty further normal sinus development.

Nawigacja śródoperacyjna w chirurgii endoskopowej zatok przynosowych

UNLABELLED Intraoperative navigation systems have been developed to increase the safety and efficiency of endoscopic sinus surgery. The objective of this study was to compare the application and utilization of optical and electromagnetical navigation systems in our own experience during the endoscopic surgery. MATERIAL AND METHODS An optical-based image guidance systems (MatrixPolar Navigation System, Xion, Germany; Karl Storz Surgical Cockpit Navigation Panel Unit, Karl Storz, Germany; Stryker Navigation CartII ENT, Stryker, USA) and electromagnetic (Fusion ENT Navigation System, Medtronic, USA; Fiagon, fiagon GmbH, Germany) was used to performed 40 sinonasal and skull base surgeries. We compared the precision and accuracy of both types of systems and additional time necessary for setting up the system and real operating room time. We also analysed the convenience of navigation according to possibilities of easy instruments manipulation and fluency of navigation process. RESULTS The mean measured accurancy of anatomical localization at start of the surgery for optical systems was 1.62 ± 0.4mm and for electromagnetic respectively 1.79 ± 0.39 mm. The time to set up the optical system was longer than for electromagnetic one (12 vs 5 minutes). Operating room time was increased for both systems, for optical to 22 vs 8 minutes for electromagnetic one. Surgeons working comfort during operation was better for electromagnetic systems and allowed for fluently movements with instruments. CONCLUSIONS Intraoperative navigation systems assist the surgeon with anatomical localization during endoscopic sinus surgery and improve its safety and efficacy. The choice of optical or electromagnetic system should be compared of effective costs and surgeons preferences.

Nasolacrimal duct obstruction after toxic epidermal necrolysis

Toxic epidermal necrolysis also known as Lyells syndrome is acute dermatomyositis as an adverse drug reactions. It is characterized by erosions of skin over 30% of total body surface area and is associated with significant mortality of 25%-50% of cases. The conjunctival mucosa involvement could result in cornea erosion and ulceration. Other ocular complications are: purulent conjunctivitis with pseudomembrane formation, entropion, symblefaron and synechiae with nasolacrimal duct obstruction or punctual stenosis. The authors present a very rare complication of nasolacrimal duct obstruction after toxic epidermal necrolysis in young girl. The endoscopic dacricystorhinostomy with one lacrimal point intubation was performed. Early ophthalmic assessment and frequent follow-up could be helpful to avoid metaplasia of epithelium, vascular neoplasia in conjunctiva and cornea. This will protect from dysfunction of tears secretion causing nasolacrimal duct or lacrimal point obliteration. If there is a permanent epiphora the endoscopic dacriocystorhinostomy, with silicone tube intubation could be the method of choice. A satisfactory results are also obtained after opening a passage of only one occluded lacrimal point.

Wartość testu Halamagyi-Curthoysa w diagnostyce neurootologicznej

Summary The aim of the study The goal of the study was to state the usefulness of the Halmagyi-Curthoys’ test in the patients with unilateral vestibular weakness. The influence of the heaviness of the canal paresis, spontaneous nystagmus and compensation on the test results was observed. Material and methods The investigation was performed in 68 patients with unilateral vestibular weakness of the various origin. Halmagyi-Curthoys’ test was done using passive way. Results In healthy subjects the test results were negative. In patients: 47% demonstrated positive test, 44,1% negative proof, in 8,9% test was difficult to estimate. Conclusions The obtained results pointed out that Halmagyi-Curthoys test is useful as orientation, preliminary examination, generally in cases with deep canal paresis (according to Dix- Hallpikes classification).

Risk factors of tympanoplasties in long-term observation

OBJECTIVES The aim of the study was to evaluate risk factors influencing the results of tympanoplasties on the base of material taken from the Department of Otolaryngology and Laryngological Oncology Collegium Medicum of Nicolaus Copernicus University in Bydgoszcz between 2004-2009. In this period 98 operations were done. The time from operation to hearing examination was 3 to 7 years, mean 5,43. Tympanoplastic operation were divided according to Tos classification. Measuring hearing results, tonal audiometry was done and mean air bone gap on four frequencies was assesed (500, 1000, 2000, 3000 Hz), according to AAO-HNS guidelines (1995). This parameter was compared between groups separated according to risk factors, that could potentially affect the results. Those risk factors were: disfunction of the Eustechian tube, localisation and size of the perforation of the tympanic membrane, damage of the ossicles, the state of the mastoid process, the number of operations, the presence of the cholesteatoma or granulating tissue, chronic otitis media in the opposite ear, smoking cigarettes, mastoidectomy, canal wall down technique. The results were analysed using statistical test. RESULTS The most impotant risk factor affecting treatments results (besides discharge from the ear) is damage of the ossicles, especially the malleus and stapes. Well done operation ensures good hearing results irrespectively of the presence of cholesteatoma or granulating tissue, and also in case of reoperation. For all types of tympanoplasties neither the localisation, nor the size of perforation do not influence on hearing results in long term observation.

Results of cystadenolymphoma treatment of superficial parotid gland

Introduction Warthins tumor is a non-malignant tumor that occurs in major salivary glands. Diagnostics include an interview and physical examination as well as additional tests - ultrasonography, magnetic resonance tomography, fine-needle aspiration biopsy. Surgical tumor resection remains the method of treatment, the scope of which includes techniques from extracapsular tumor resection to a full range of parotidectomy. Material and methods A retrospective analysis was conducted for available medical records of 53 patients treated surgically at the Department of Otolaryngology and Laryngological Oncology at the Collegium Medicum of the Nicolaus Copernicus University in Toruń in 2009-2016. Each patient underwent an interview, physical examination and a routine ultrasound examination. Results of treatment of 57 tumors were analyzed. Results The study showed that in the case of extracapsular tumor excision in 57 patients in the treatment of Warthins tumors of the lower pole of the parotid lobe, there were no complications in the form of: permanent paralysis or facial nerve palsy, mucocele, symptoms of Freys syndrome or cosmetic facial defect. Ultrasound examination in 8 (14%) patients revealed changes requiring further diagnostics or periodic ultrasound monitoring. Conclusions 1. Extracapsular tumor excision appears to be an accurate surgical technique in Warthins tumor of the lower pole of the parotid glands superficial lobe. 2. After removal of a cancerous lesion of the parotid gland, every patient requires periodic laryngological monitoring.

The late results of 4000 Hz frequency bone conduction after tympanoplasty

INTRODUCTION Surgical treatment of conductive hearing loss runs the risk of damage to the inner ear in the mechanism of acoustic trauma. AIM The aim of this study was to evaluate the function of the organ of Corti, expressed as bone conduction threshold at the frequency of 4000 Hz for selected operations: mastoidectomy and canal-wall-down procedure. MATERIAL AND METHODS The material was collected from patients with chronic otitis media in the Department of Otolaryngology and ENT Oncology, Collegium Medicum of Nicolaus Copernicus University in Bydgoszcz in 2004-2009. All patients were examined with pure tone audiometry threshold before surgery and at least three years after surgery. The analyzed group of patients was divided into subgroups depending on the type of operation according to To classification and procedures for resection: mastoidectomy and canal-wall-down procedure. The results were statistically analyzed. RESULTS In the analyzed period of three years after surgery there was no statistically significant difference between groups, although there were higher values for tympanoplasty type 1 with mastoidectomy compared with tympanoplasty type 1 without mastoidectomy - respectively 25.67 dB and 18.53 dB. In the study, there was no statistically significant the difference in bone conduction threshold for frequency 4000 Hz within the type 2 tympanoplasty according to Tosa comparing canal wall-up and canal-wall-down procedure. CONCLUSIONS Mastoidectomy or canal-wall-down procedure do not affect the bone conduction threshold for a frequency of 4000 Hz after tympanoplasty in long-term observation.