Wolfgang Gau

Mass spectrometric identification of xanthophyll fatty acid esters from marigold flowers (tagetes erecta) obtained by high performances liquid chromatography and craig counter-current distribution

Abstract By means of reversed-phase high-performance liquid chromatography in the system acetonitrile-dichloromethane, the xanthophyll fatty acid esters from a purified extract of marigold flower petals (Tagetes erecta) were isolated on a semipreparative scale. The structures of the xanthophyll fatty acid esters were elucidated by mass spectrometry. The presence of the hitherto unknown mixed esters xanthophyll palmitate stearate and xanthophyll palmitate myristate was demonstrated, in addition to the major component xanthophyll dipalmitate. The latter was isolated in larger quantities from the xanthophyll fatty acid ester mixture by Craig counter-current distribution.

Analytische Charakterisierung von Palatinit

SummaryThe reaction product of the catalytic hydrogenation of isomaltulose (palatinose) is a mixture ofα-d-glucopyranosido-1,6-sorbitol and α-d-glucopyranosido-1,6-mannitol designated palatinit. Because of its high potential as a sugar substitute methods for the identification and characterization of hydrogenation products and for the determination of palatinit as an ingredient in food preparations and biological samples are required. Several working procedures are described in full detail including thin layer and gas chromatography as well as enzymatic and chemical determinations.ZusammenfassungDas Reaktionsprodukt der katalytischen Hydrierung von Isomaltulose (Palatinose) ist eine Mischung vonα-d-Glucopyranosido-1,6-sorbit undα-d-Glucopyranosido-1,6-mannit und wird als Palatinit bezeichnet. Seine Eignung als potentieller Zuckeraustauschstoff macht Methoden zur Identifizierung und Charakterisierung der Hydrierungsprodukte und zur Bestimmung von Palatinit als Bestandteil von Lebensmitteln und biologischem Material erforderlich. Mehrere Arbeitsvorschriften werden detailliert wiedergegeben; sie umfassen Dünnschicht- und Gaschromatographie ebenso wie enzymatische und chemische Bestimmungsmethoden.

The pharmacokinetics of furazlocillin in healthy humans

AbstractThe pharmacokinetics of the novel acylureidopenicillin furazlocillin, 6-[D-2-(3-furfurylidenamino-2-oxo-imidazolidine-1-carboxamido)-2-(4-hydroxyphenyl)-acetamido]-penicillanic acid and of its penicilloic acid derivative were investigated in five healthy male volunteers after intravenous administration of 2 and 4 g dosages. The volunteers were either in a lying or sitting position throughout the duration of the studies. The concentrations of the drug in plasma and urine were measured by two different methods in parallel: a microbiological assay and a newly developed high pressure liquid chromatography method. The latter method was also applicable for quantitation of the penicilloic acid derivative in these biological fluids. The drugs plasma protein binding (66%) and apparent red cell-plasma partition coefficient (0.055) were concentration independent. The pharmacokinetics of the drug were first order only at the lower dose level The apparent half lives of three distinguishable phases were, respectively, 4

Chemistry, stereochemistry and biological properties of KWG 4168

(t_{1/2_1 } )

Use of glucopyranosido-1,6-mannitol as a sugar substitute

, 18

Glucopyranosido-1,6-mannitol, a process for producing the same and its use as a sugar substitute

(t_{1/2_2 } )