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Featured researches published by Wolfram Grüning.
BMJ Open | 2013
Christian Boch; Jens Kollmeier; A Roth; Susann Stephan-Falkenau; Daniel Misch; Wolfram Grüning; Torsten T. Bauer; Thomas Mairinger
Objectives Owing to novel therapy strategies in epidermal growth factor receptor (EGFR)-mutated patients, molecular analysis of the EGFR and KRAS genome has become crucial for routine diagnostics. Till date these data have been derived mostly from clinical trials, and thus collected in pre-selected populations. We therefore screened ‘allcomers’ with a newly diagnosed non-small cell lung carcinoma (NSCLC) for the frequencies of these mutations. Design A cohort study. Setting Lung cancer centre in a tertiary care hospital. Participants Within 15 months, a total of 552 cases with NSCLC were eligible for analysis. Primary and secondary outcome measures Frequency of scrutinising exons 18, 19 and 21 for the presence of activating EGFR mutation and secondary codon 12 and 13 for activating KRAS mutations. Results Of the 552 patients, 27 (4.9%) showed a mutation of EGFR. 19 of these patients (70%) had deletion E746-A750 in codon 19 or deletion L858R in codon 21. Adenocarcinoma (ACA) was the most frequent histology among patients with EGFR mutations (ACA, 22/254 (8.7%) vs non-ACA, 5/298 (1.7%); p<0.001). Regarding only ACA, the percentage of EGFR mutations was higher in women (16/116 (14%) women vs 6/138 (4.3%) men; p=0.008). Tumours with an activating EGFR mutation were more likely to be from non-smokers (18/27; 67%) rather than smoker (9/27; 33%). KRAS mutation was present in 85 (15%) of all cases. In 73 patients (86%), the mutation was found in exon 12 and in 12 cases (14%) in exon 13. Similarly, ACA had a higher frequency of KRAS mutations than non-ACA (67/254 (26%) vs 18/298 (6.0%); p<0.001). Conclusions We found a lower frequency for EGFR and KRAS mutations in an unselected Caucasian patient cohort as previously published. Taking our results into account, clinical trials may overestimate the mutation frequency for EGFR and KRAS in NSCLC due to important selection biases.
Diagnostic Pathology | 2011
Sergej Griff; Wim Ammenwerth; N Schönfeld; Torsten T. Bauer; Thomas Mairinger; Torsten-Gerriet Blum; Jens Kollmeier; Wolfram Grüning
The recent introduction of bronchoscopically recovered cryobiopsy of lung tissue has opened up new possibilities in the diagnosis of neoplastic and non-neoplastic lung diseases in various aspects. Most notably the morphological diagnosis of peripheral lung biopsies promises to achieve a better yield with a high quality of specimens. To better understand this phenomenon, its diagnostic options and perspectives, this study morphometrically compares 15 cryobiopsies and 18 transbronchial forceps biopsies of peripheral lung tissue a priori without considering clinical hit ratio or integration of results in the clinical diagnostic processing. Cryotechnically harvested specimens were significantly larger (mean: 17.1 ± 10.7 mm2 versus 3.8 ± 4.0 mm2) and contained alveolar tissue more often. If present, the alveolar part in cryobiopsies exceeded the one of forceps biopsies. The alveolar tissue of crybiopsy specimens did not show any artefacts. Based on these results cryotechnique seems to open up new perspectives in bronchoscopic diagnosis of lung disease.
Diagnostic Pathology | 2016
Sergej Griff; Wim Ammenwerth; N Schönfeld; Torsten T. Bauer; Thomas Mairinger; Torsten-Gerriet Blum; Jens Kollmeier; Wolfram Grüning
© 2016 The Author(s). Open Access This artic International License (http://creativecommons reproduction in any medium, provided you g the Creative Commons license, and indicate if (http://creativecommons.org/publicdomain/ze • We accept pre-submission inquiries • Our selector tool helps you to find the most relevant journal • We provide round the clock customer support • Convenient online submission • Thorough peer review • Inclusion in PubMed and all major indexing services • Maximum visibility for your research
BMC Pulmonary Medicine | 2014
Sergej Griff; N Schönfeld; Wilhelm Ammenwerth; Torsten-Gerriet Blum; Christian Grah; Torsten T. Bauer; Wolfram Grüning; Thomas Mairinger; Henrik Wurps
European Respiratory Journal | 2012
Henrik Wurps; Sergej Griff; Wim Ammenwerth; Torsten Blum; N Schönfeld; Thomas Mairinger; Torsten T. Bauer; Wolfram Grüning
European Respiratory Journal | 2012
Henrik Wurps; Sergej Griff; Michael Knappik; N Schönfeld; Torsten T. Bauer; Thomas Mairinger; Wolfram Grüning
European Respiratory Journal | 2012
Daniel Misch; Jens Kollmeier; Torsten Blum; Sergej Griff; Christian Boch; Timo Weiss; Catharina Crolow; Wolfram Grüning; Thomas Mairinger; Torsten T. Bauer
European Respiratory Journal | 2012
Catharina Crolow; Markus Samulowski; Timo Weiss; Torsten Blum; Jens Kollmeier; N Schönfeld; Wolfram Grüning; Torsten T. Bauer
European Respiratory Journal | 2011
Daniel Misch; Jens Kollmeier; Sergej Griff; Christian Boch; Kaja Zimmermann; Torsten Blum; Wolfram Grüning; Thomas Mairinger; Torsten T. Bauer
European Respiratory Journal | 2011
Wolfram Grüning; Sergej Griff; Henrik Wurps; Wim Ammenwerth; Torsten-Gerriet Blum; Jens Kollmeier; Nikolas Schönfeld; Christian Boch; Susann Stephan-Falkenau; Thomas Mairinger; Torsten T. Bauer