Wook Jeong
Pohang University of Science and Technology
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Publication
Featured researches published by Wook Jeong.
Journal of the American Chemical Society | 2009
Cheoljae Kim; Hyo Jin Bae; Ji Hyung Lee; Wook Jeong; Haejin Kim; Vasu Sampath; Young Ho Rhee
A new gold(I)-catalyzed cycloisomerization to access highly substituted piperidines has been developed. By combining a conceptually new way of generating iminium ions using cationic gold(I) complexes and an efficient cyclization reaction that can minimize a potentially competing aza-Cope rearrangement, the proposed reaction successfully circumvents a long-standing problem in the classical aza-Prins reaction. Synthetic utility of the catalytic reaction was demonstrated by a synthesis of optically active 2-alkyl-piperidin-4-one.
RSC Advances | 2014
Wook Jeong; Ji Hyung Lee; Jungjoon Kim; Won Jong Lee; Ju-Hwa Seong; Jaiwook Park; Young Ho Rhee
A new synthetic method for homopropargylic amines from alkyl azides is presented. A salient feature of this reaction is the involvement of N-unsubstituted imines as the key intermediates, which are generated from alkyl azides by Ru catalysis under photolytic conditions. Notably, this method avoids the use of a protective group strategy in the homopropargylic amine synthesis.
Organic Letters | 2017
Soyeong Kang; Seok Hyeon Jang; Juyeol Lee; Dong-gil Kim; Mijin Kim; Wook Jeong; Young Ho Rhee
Catalytic asymmetric synthesis of N-heterocyclic glycosides free of protecting and directing groups is reported. The key reaction is highlighted by the atom-efficient and regioselective addition of unprotected pyrimidines to highly functionalized alkoxyallene. Numerous acyclic and cyclic N-heterocyclic glycosides are accessed with minimal formation of organic byproducts. The synthetic utility of the reaction is demonstrated by the first catalytic asymmetric synthesis of anticancer pharmaceutical (-)-Tegafur and stereoselective synthesis of an oxepane nucleoside derivative.
Organic Letters | 2017
Jungjoon Kim; Wook Jeong; Young Ho Rhee
A flexible synthetic method toward highly substituted tetrahydropyran is reported. The key transformation involves atom-efficient sequential metal catalysis consisting of Pd-catalyzed addition of homopropargylic alcohols to alkoxyallene and the subsequent gold(I)-catalyzed cycloisomerization. Notably, this method gives access to both 2,6-cis- and 2,6-trans-tetrahydropyrans possessing diverse substitution patterns.
Organic Letters | 2018
Seok Hyeon Jang; Hyunwoo Kim; Wook Jeong; Dohyun Moon; Young Ho Rhee
A new palladium-catalyzed asymmetric addition reaction of indoles to alkoxyallenes is reported. Remarkably, the reaction showed complete regioselectivity toward the nitrogen. A new mechanism distinct from that of conventional π-allyl chemistry is proposed to explain this unique selectivity. The utility of the reaction is demonstrated by highly efficient and flexible synthesis of N-glycosylindoles.
Angewandte Chemie | 2012
Jin Hee Lee; Sreya Gupta; Wook Jeong; Young Ho Rhee; Jaiwook Park
Chemistry: A European Journal | 2011
Hyo Jin Bae; Wook Jeong; Ji Hyung Lee; Young Ho Rhee
Advanced Synthesis & Catalysis | 2015
Dong-gil Kim; Wook Jeong; Won Jong Lee; Soyeong Kang; Han Kyu Pak; Jaiwook Park; Young Ho Rhee
Synthesis | 2014
Ji Hyung Lee; Wook Jeong; Young Ho Rhee
European Journal of Organic Chemistry | 2014
Wook Jeong; Jungjoon Kim; Jaiwook Park; Young Ho Rhee