Wooseok Jung

A novel lab-on-a-tube for multimodal monitoring of patients with traumatic brain injury

A novel lab-on-a-tube (LOT) integrated with spirally-rolled pressure, temperature, oxygen and glucose microsensors has been designed, fabricated, and characterized for multimodal neuromonitoring of patients with traumatic brain injury and other acute neurosurgical and neurological disorders. While it is capable of measuring various crucial physiological parameters in real-time continuous formats, the LOT if placed in the lateral ventricle of the brain, can also lower the elevated intracranial pressure by draining cerebrospinal fluid (CSF). A customized signal conditioning circuit and monitor have been developed to record and display the measured data. The newly developed system is capable of reliably monitoring physiological and metabolic parameters in CSF for at least up to 5 days. The device represents a very significant advance in the technology of neuromonitoring.

An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH)

A new sample-to-answer polymer lab-on-a-chip, which can perform immunoassay with minimum user intervention through on-chip reservoirs for reagents and single microchannel assay, has been designed, developed and successfully characterized as a point-of-care testing (POCT) cartridge for the detection of thyroid stimulating hormone (TSH). Users only need to drop a sample to the POCT cartridge to obtain test results within 30 minutes. The analyzed results of TSH showed a linear range up to 55 μIU/mL with the limit of detection (LOD) of 1.9 μIU/mL at the signal to noise ratio (SNR) of 3. The reagents stored in the on-chip reservoirs maintained their volume more than 97 % of initial volume for 100 days of storage time while the detection antibody retained its activity above 97 %.

A sensing tube with an integrated piezoelectric flow sensor for liver transplantation

An innovative sensing tube with an integrated piezoelectric flow sensor to measure flow rate in portal vein during liver transplantation has been developed and characterized in this work. This smart tube aims to measure flow rates in the portal vein in a real-time continuous format with high reliability. The PVDF-TrFE piezoelectric flow sensor integrated in a tube was able to measure flow rates with the sensitivity of 0.02 mVpp per 20 mL/min in the range of portal vein flow rate. It also showed excellent operational stability for 120 minutes with a standard deviation of 0.084 mVpp. The tube can be used as a clinical tool for assessing the need for portal vein inflow modification during liver transplantation.