Wu Yongjiang
Zhejiang University
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Journal of Zhejiang University Science | 2004
Wu Yongjiang; Ma Ming-ming; Zeng Su
The enantioselective assay for S(+)-and R(-)-propafenone (PPF) in human urine that developed in this work involves extraction of propafenone from human urine and using S(+)-propafenone as internal standard, chiral derivatization with 2,3,4,6-tetra-O-β-D-glucopranosyl isothiocyanate, and quantitation by an RP-HPLC system with UV detection (γ-220 nm). A baseline separation of propafenone enantiomers was achieved on a 5-μm reverse phase ODS column, with a mixture of methanol:water:glacial acetic acid (25∶12∶0.02, v/v) as mobile phase. There was good linear relationship from 24.9 ng/ml to 1875.0 ng/ml for both of enantiomers. The regression equations of the standard curves based on CS-PPF (or CR-PPF) versus ratio of AS-PPF/As (or AR-PPF/As) werey=0.0032x−0.081, (r=0.999) for S-PPF andy=0.0033x+0.0039, (r=0.998) for R-PPF, respectively. The method’s limit of detection was 12.5 ng/ml for both enantiomers, and the method’s limit of quantitation was 28.2±0.52 ng/ml for S-PPF, 30.4±0.53 ng/ml for R-PPF (RSD<8%,n=5). The analytical method yielded average recovery of 98.9% and 100.4% for S-PPF and R-PPF, respectively. The relative standard derivation was no more than 6.11% and 6.22% for S-PPF and R-PPF, respectively. The method enabled study of metabolism of S(+)-and R(-)-propafenone in human urine. The results from 7 volunteers administered 150 mg racemic propafenone indicated that propafenone enantiomers undergo stereoselective metabolism and that in the human body, S(+)-propafenone is metabolized more extensively than R(-)-propafenone.
Journal of Pharmaceutical and Biomedical Analysis | 2003
Zhang Haijiang; Wu Yongjiang; Cheng Yiyu
Archive | 2014
Yao Xiaoqing; Liu Xuesong; Sun Changhai; Jin Ye; Chen Yong; Wu Yongjiang; Wang Longhu
Archive | 2013
Chen Yong; Liu Xuesong; Li Yerui; Chen XueYing; Wang Longhu; Wu Yongjiang; Jin Ye
Archive | 2004
Wu Yongjiang; Cheng Yiyu; Luan Lianjun
Archive | 2016
Liu Xuesong; Chen Yong; Li Yerui; Wu Yongjiang; Lin Zhizhan
Archive | 2013
Liu Xuesong; Chen Yong; Wu Yongjiang; Wang Longhu; Wan Xinmin; Chen Kangyu; Jin Ye; Li Yerui
Archive | 2015
Liu Xuesong; Sun Fenfang; Jin Ye; Wu Yongjiang; Chen Yong
Archive | 2015
Chen Yong; Geng Shu; Wu Yongjiang; Liu Xuesong; Jin Ye
Archive | 2014
Chen Yong; Jin Ye; Geng Shu; Wu Yongjiang; Liu Xuesong; Han Xiaoyan