Wynn A. Volkert

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International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology | 1990

Jaime Simon; David A. Wilson; Wynn A. Volkert; David E. Troutner; William F. Goeckeler

Particle-emitting radionuclides, e.g. Samarium-153, have been complexed with organic aminoalkylenephosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions for the therapeutic treatment of calcific tumors in animals.

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology | 1990

Jaime Simon; Wynn A. Volkert; David A. Wilson; David E. Troutner; William F. Goeckeler

Certain particle-emitting radionuclides, e.g. Samarium-153, have been complexed with certain alkylenepolyaminocarboxylic acid chelants. Compositions containing these complexes have been found useful in the treatment of calcific tumors in animals. The stability constant, log K, of the useful complexes is from about 14 to about 17 and the molar ratio of chelant to radionuclide in the compositions is such that the chelant is present in an amount sufficient to inhibit uptake of the radionuclide by soft tissue.

Archive | 1984