Xiajing Tang

Corneal astigmatism, high order aberrations, and optical quality after cataract surgery: microincision versus small incision.

PURPOSE To compare the astigmatism, high order aberrations, and optical quality of the cornea after microincision (approximately 1.7 mm) versus small incision approximately 3.2 mm) cataract surgery at Eye Center, Zhejiang University, Hangzhou, China. METHODS This prospective, randomized clinical study included microincision cataract surgery and small incision cataract surgery performed on 60 eyes. Corneal astigmatism and higher order aberrations to the sixth order were measured using the NIDEK OPD-Scan aberrometer/topographer 1 month after surgery. To evaluate the optical quality of the cornea, the 0.5 modulation transfer function (MTF) value and 0.1 MTF value within a 5-mm pupil were calculated using OPD-Station software. Statistical analysis assessing the difference between groups was carried out using the independent t test. RESULTS The mean corneal astigmatism was significantly lower after microincision cataract surgery compared with small incision cataract surgery (0.78+/-0.38 diopters [D] vs 1.29+/-0.68 D, respectively; P=.001). No significant differences were found between the two groups for the root-mean-square value of total high order aberrations or individual high order aberrations for spherical aberration, coma, and trefoil. However, eyes that underwent microincision cataract surgery showed statistically significantly better optical performance with a 0.5 MTF value than eyes that underwent small incision cataract surgery (3.13+/-0.30 cycles per degree [cpd] vs 2.75+/-0.63 cpd, respectively; P=.005). The 0.1 MTF values for the two groups were 9.37+/-3.72 cpd for microincision cataract surgery and 7.24+/-3.43 cpd for small incision cataract surgery, which was not significantly different (P=.136). CONCLUSIONS Microincision cataract surgery generates statistically significantly less corneal astigmatism and better optical quality of the cornea by MTF evaluation compared with small incision cataract surgery. However, microincision cataract surgery shows no significant advantage in reducing corneal high order aberrations over small incision cataract surgery.

Spherical aberration, visual performance and pseudoaccommodation of eyes implanted with different aspheric intraocular lens

Purpose:  To compare spherical aberration, visual performance and pseudoaccommodation in pseudophakic eyes implanted with aspheric intraocular lenses (IOLs) of Tecnis Z9001 with negative spherical aberration (AMO Inc.), aspheric aberration‐free IOLs of Akreos AO (Bausch & Lomb Inc.) and spherical IOLs of KS‐1 (Cannon Staar Inc.).

Protective effect of magnolol against hydrogen peroxide-induced oxidative stress in human lens epithelial cells.

Oxidative stress plays a significant role in the progression of cataract. We aimed to investigate the protective effect of magnolol, a compound extracted from the Chinese herb Magnolia officinalis, against oxidative stress in human lens epithelial (HLE) cells as well as the possible molecular mechanism involved. In this study, magnolol was observed to protect against H2O2-induced cytotoxicity in HLE B-3 cells. Magnolol inhibited the generation of reactive oxygen species (ROS), loss of mitochondrial membrane potential (Delta psi m) and release of cytochrome c from mitochondria caused by H2O2 into cytosol in HLE B-3 cells. Magnolol also inhibited H2O2-induced expressions of caspase-9 and caspase-3 and reduction of Bcl-2/Bax ratio. Moreover, magnolol attenuated the deactivation of ERK/MAPK (extracellular signal-regulated kinase/mitogen activated protein kinase) and the enhanced activation of p38, JNK (c-Jun N-terminal kinase) induced by H2O2. Magnolol could be useful in protecting against oxidative stress in HLE cells, suggesting a potential protective effect against cataractogenesis effect against cataractogenesis.

Combined microwave energy and fixative agent for cataract induction in pig eyes.

&NA; We describe a technique used in enucleated pig eyes to create a uniformly hardened lens nucleus and an anterior capsule similar to the cataractous human lens. After treatment with microwave heat and a fixative agent, the pig eyes have clear corneas, anterior capsules with less tension and elasticity, and harder lens nuclei, with a consistency similar to that of a nuclear sclerosis grade I to V in the Emery‐Little classification. The eyes can be used by residents in training to practice various phacoemulsification techniques, including continuous curvilinear capsulorhexis, hydrodelineation, sculpting, divide and conquer, phaco chop, and nondividing phacoemulsification.

Conductive keratoplasty for symptomatic presbyopia following monofocal intraocular lens implantation

Background:  To evaluate the visual outcomes of conductive keratoplasty for relief of symptomatic presbyopia of pseudophakia with monofocal intraocular lens implantation.

Clinical evaluation using Custom Control Software technology in coaxial phacoemulsification.

Purpose:  The aim of this study was to evaluate the clinical outcomes of the Custom Control Software technology in coaxial phacoemulsification.