Xian-Min Zhang
Chinese Academy of Sciences
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Publication
Featured researches published by Xian-Min Zhang.
Phytochemistry | 2009
Jian-Chao Chen; Wu-Qing Liu; Lu Lu; Ming-Hua Qiu; Yong-Tang Zheng; Liu-Meng Yang; Xian-Min Zhang; Lin Zhou; Zhong-Rong Li
Chemical investigation of the vines and leaves of Momordica charantia resulted in isolation of fourteen cucurbitane triterpenoids, kuguacins F-S (1-14), including two pentanorcucurbitacins (6 and 7), one octanorcucurbitacin (8), and two trinorcucurbitacins (11 and 12), along with six known analogues. Their structures were elucidated on the basis of extensive spectroscopic and single-crystal X-ray diffraction analyses. Compounds 1-14 exhibited weak anti-HIV-1 activities in vitro.
Molecules | 2007
Ying Qiao; Xian-Min Zhang; Ming-Hua Qiu
Two novel lanostane-type triterpenes, Ganolactone B and Ganoderiol A triacetate, were isolated from the fruiting bodies of G. sinense, together with six known compounds. The structures of the two new triterpenes were determined as 3beta,7beta- dihydroxy-11,15-dioxo-lanosta-8-en-24-->20 lactone (1) and 3beta,24,26-triacetoxy-5alpha-lanosta-7,9(11)-dien-25-ol (2), respectively, by chemical and spectroscopic means.
Steroids | 2010
Yun Sun; Yu-Xin Yan; Jian-Chao Chen; Lu Lu; Xian-Min Zhang; Yan Li; Ming-Hua Qiu
Nine new pregnane alkaloids, pachysamines J-R (1-9), together with seven known ones, were isolated from Pachysandra axillaris. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 cell lines. Compound 15 possessed moderate activities against A-549, SK-BR-3, and PANC-1 cells, with the IC(50) values of 11.17, 4.17, and 10.76 microM, respectively. Besides, compound 11 showed cytotoxicities against A-549 cell, with the IC(50) values as 24.94 microM.
Journal of Natural Products | 2009
Yu-Xin Yan; Xiaodong Hu; Jian-Chao Chen; Yun Sun; Xian-Min Zhang; Chen Qing; Ming-Hua Qiu
Five new triterpenoid alkaloids, buxmicrophyllines E-I (1-5), and six known ones (6-11) were isolated from the leaves and stems of Buxus microphylla. The structures of compounds 1-5 were elucidated by NMR and MS spectroscopic analysis, and the relative stereochemistry of 5 was determined by single-crystal X-ray crystallography. Compounds 3 and 9 were cytotoxic against HepG2 cells, with IC(50) values of 0.89 and 0.78 microM, and compounds 2, 3, 7, 8, and 9 were cytotoxic against K562 cells, with IC(50) values of 2.95, 4.44, 1.70, 5.61, and 0.37 microM, respectively.
Bioorganic & Medicinal Chemistry | 2009
Jian Yan; Lirong Sun; Guisheng Wu; Ping Yi; Fumei Yang; Lin Zhou; Xian-Min Zhang; Zhong-Rong Li; Xiaosheng Yang; Huai-Rong Luo; Ming-Hua Qiu
By targeting multi-active sites of acetylcholinesterase (AChE), a series of huperzine A (Hup A) derivatives with various aromatic ring groups were designed and synthesized by Schiff reaction. They were evaluated as AChE and butyrylcholinesterase (BChE) inhibitors. Results showed very significant specificity that the group of imine derivatives could inhibit TcAChE and hAChE, but no inhibitory effect on hBChE was detected. The experiment was explained by a docking study. In the docking model, we confirmed that aromatic ring of Hup A derivatives played the pi-pi stacking against aminophenol residues of AChE, and the structure-activity relationship (SAR) was discussed.
Planta Medica | 2010
Jian Yan; Lirong Sun; Wei Li; Lin Zhou; Zhong-Rong Li; Xian-Min Zhang; Ling Yang; Ming-Hua Qiu
Four serratane-type triterpenes ( 1- 4) were isolated from D. COMPLANATUM. Their chemical structures were elucidated as 14alpha,15alpha,20beta,21beta,24,27alpha,29-heptahydroxyserrat-3-one ( 1), 3beta,14alpha,15alpha,20beta,21beta,24,27alpha,29-octahydroxyserratane ( 2), 3alpha,14alpha,20beta,21beta,24,27alpha,29-heptahydroxyserratane ( 3) and 3beta,14alpha,21beta,24,27alpha-pentahydroxyl-serratane-29-yl ( E)- P-coumarate ( 4) by spectroscopic methods (MS, 1D and 2D NMR) and X-ray crystallography. Interestingly, the most characteristic methylene (C-27) of the serratane ring C was oxidized to a methine. Compound 4 showed significant cytotoxic activity against the human leukemia K562/S and the doxorubicin-resistant K562/R cell lines, but the other compounds were inactive.
Phytochemistry | 2011
Yin Nian; Xian-Min Zhang; Yan Li; Yuan-Yuan Wang; Jian-Chao Chen; Lu Lu; Lin Zhou; Ming-Hua Qiu
Helvetica Chimica Acta | 2007
Lirong Sun; Jian Yan; Lu Lu; Sheng-Ji Pei; Zhong-Rong Li; Lin Zhou; Xian-Min Zhang; Ming-Hua Qiu
Phytochemistry | 2008
Jian Yan; Ping Yi; Baohui Chen; Lu Lu; Zhong-Rong Li; Xian-Min Zhang; Lin Zhou; Ming-Hua Qiu
Helvetica Chimica Acta | 2009
Zhen-Jie Li; Jian-Chao Chen; Yun Sun; Na-Li Song; Bao-Hui Cheng; Lu Lu; Wei-guang Ma; Lin Zhou; Xian-Min Zhang; Zhong-Rong Li; Ming-Hua Qiu