Xian-Rong Song
Lanzhou University
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Publication
Featured researches published by Xian-Rong Song.
Organic Letters | 2011
Shaukat Ali; Hai-Tao Zhu; Xiao-Feng Xia; Ke-Gong Ji; Yan-Fang Yang; Xian-Rong Song; Yong-Min Liang
Highly substituted 3-iodoquinolines bearing different alkyl and aryl moieties can be synthesized in moderate to excellent yields (up to 99%) by 6-endo-dig iodocyclization of 2-tosylaminophenylprop-1-yn-3-ols with molecular iodine (I(2)) under mild conditions. The cyclization is highly regioselective and the resulting 3-iodoquinolines can be further functionalized by various coupling reactions.
Chemistry: A European Journal | 2015
Pin Gao; Xian-Rong Song; Xue-Yuan Liu; Yong-Min Liang
In the last few years, the development of versatile methodologies to incorporate trifluoromethyl groups into organic molecules has attracted significant attention in synthetic chemistry. This review gives an overview over the development on the trifluoromethylation of alkynes, which have not been solely discussed before. Formation of diverse C(sp, sp(2) , sp(3) )-CF3 bonds are all covered in this review.
Journal of Organic Chemistry | 2012
Xiao-Feng Xia; Ning Wang; Lu−Lu Zhang; Xian-Rong Song; Xue-Yuan Liu; Yong-Min Liang
A palladium-catalyzed tandem cyclization/C-H functionalization of two alkynes was accomplished to construct a series of polycyclic functionalized indoles. A range of internal alkynes bearing synthetically useful functional groups were tolerated. A good regioselectivity was observed when alkyl-substituted alkynes were introduced into the reaction system, and a single product was obtained. Molecular oxygen was used as the terminal oxidant in the approach, rendering the reaction more sustainable.
Chemistry: A European Journal | 2013
Pin Gao; Xiao-Biao Yan; Tao Tao; Fan Yang; Ting He; Xian-Rong Song; Xue-Yuan Liu; Yong-Min Liang
Regioselective trifluoromethylation-cyclization: A method for copper-catalyzed trifluoromethylation-cyclization of simple enynes using the CC triple bond as a nucleophile is reported for the first time. The reaction proceeds efficiently in a highly regioselective manner to give various 5- or 6-exo-dig carbocycles and heterocycles in moderate to high yields.
Organic Letters | 2012
Xiao-Feng Xia; Lu-Lu Zhang; Xian-Rong Song; Xue-Yuan Liu; Yong-Min Liang
A novel copper-catalyzed oxidative cyclization of enynes and in situ formed enynes leading to 4-carbonyl-quinolines by using dioxygen as an oxygen source has been developed.
Organic Letters | 2014
Pin Gao; Hong-Xia Li; Xin-Hua Hao; Dong-Po Jin; Dao-Qian Chen; Xiao-Biao Yan; Xin-Xing Wu; Xian-Rong Song; Xue-Yuan Liu; Yong-Min Liang
A novel iron-catalyzed aerobic oxidative reaction to synthesize disubstituted isoxazoles from homopropargylic alcohol, t-BuONO, and H2O is developed. The method provides mild conditions to afford a variety of useful substituted heterocycles in an efficient and regioselective manner. The mechanism has been studied and proposed, which indicates that the transformation can be realized through construction of a C═N bond and C═O bond, C-H oxidation, and then cyclization. Moreover, this method can be enlarged to gram scale.
Chemistry: A European Journal | 2014
Xiao-Feng Xia; Yu-Qi Wang; Lu-Lu Zhang; Xian-Rong Song; Xue-Yuan Liu; Yong-Min Liang
A new and efficient Pd(II) -catalyzed intermolecular annulation of N-benzoylsulfonamide with allenes for the synthesis of 3,4-dihydroisoquinolin-1(2H)-ones is reported. This CH functionalization is compatible with ambient air and moisture, and it can be applied to terminal or internal allenes with different synthetically attractive functional groups. Control experiments and a kinetic isotope effect study are conducted and a plausible mechanism is proposed.
Organic Letters | 2012
Xian-Rong Song; Xiao-Feng Xia; Qing-Bao Song; Fang Yang; Ying-Xiu Li; Xue-Yuan Liu; Yong-Min Liang
An efficient and selective gold-catalyzed cascade reaction for the synthesis of oxanorbornenes and naphthalene derivatives from easily prepared hydroxy enynes has been developed. Divergent products could be obtained from the same substrates by different gold catalytic systems.
Journal of Organic Chemistry | 2014
Xian-Rong Song; Bo Song; Yi-Feng Qiu; Ya-Ping Han; Zi-Hang Qiu; Xin-Hua Hao; Xue-Yuan Liu; Yong-Min Liang
A new method with high efficiency for the synthesis of α,β-unsaturated amides from the easily prepared propargyl alcohols and TMSN3 using TMSCl as an acid promoter is developed. A wide variety of α,β-unsaturated amides were produced in moderate to excellent yields. Mechanistic studies indicate that this transformation involves TMSCl-mediated allenylazide intermediate formation, C-C bond cleavage, and C-N bond formation. Significantly, this reaction shows good functional group compatibility and high regioselectivity, with a relatively short reaction time and inexpensive reagents.
Chemical Communications | 2015
Dao-Qian Chen; Pin Gao; Ping-Xin Zhou; Xian-Rong Song; Yi-Feng Qiu; Xue-Yuan Liu; Yong-Min Liang
A facile access to 4-((trifluoromethyl)thio)-2,3-dihydrofurans from unprotected homopropargylic alcohols in high regioselectivity is reported. This method is the first example of using a free hydroxy group as a nucleophile to complete a trifluoromethylthiolation/cyclization protocol with an alkyne in moderate to excellent yields.