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Xiao-Ling Shen

City University of Hong Kong

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Publication

Featured researches published by Xiao-Ling Shen.

Journal of Natural Products | 2008

Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells.

Yingjie Hu; Xiao-Ling Shen; Honglong Lu; Yu-Hu Zhang; Xin-An Huang; Linchun Fu; Wang-Fun Fong

Tenacissimoside A (1) and 11alpha-O-benzoyl-12beta- O-acetyltenacigenin B (2), two derivatives of tenacigenin B (3) from the plant Marsdenia tenacissima, reversed multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells. The sensitivity of HepG2/Dox cells to the antitumor drugs doxorubicin, vinblastine, puromycin, and paclitexel was increased by 18-, 10-, 11-, and 6-fold by 20 microg/mL (or 25 microM) of 1 and 16-, 53-, 16-, and 326-fold by 20 microg/mL (or 39 microM) of 2, respectively. A preliminary mechanistic study has suggested that 1 might modulate Pgp-mediated multidrug resistance through directly interacting with the Pgp substrate site.

Biochemical Pharmacology | 2005

Honokiol inhibits TNF-α-stimulated NF-κB activation and NF-κB-regulated gene expression through suppression of IKK activation

Anfernee Kai-Wing Tse; Chi-Keung Wan; Xiao-Ling Shen; Mengsu Yang; Wang-Fun Fong

Biochemical Pharmacology | 2006

Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells

Chi-Keung Wan; Guo-Yuan Zhu; Xiao-Ling Shen; Apurba Chattopadhyay; Saibal Dey; Wang-Fun Fong

Molecular Immunology | 2007

Magnolol suppresses NF-κB activation and NF-κB regulated gene expression through inhibition of IkappaB kinase activation

Anfernee Kai-Wing Tse; Chi-Keung Wan; Guo-Yuan Zhu; Xiao-Ling Shen; Hon-Yeung Cheung; Mengsu Yang; Wang-Fun Fong

Biochemical Pharmacology | 2004

Reversal of P-glycoprotein-mediated multidrug resistance by Alisol B 23-acetate.

Cheng Wang; J. X. Zhang; Xiao-Ling Shen; Chi-Keung Wan; Anfernee Kai-Wing Tse; Wang-Fun Fong

Planta Medica | 2007

Schisandrol A from Schisandra chinensis reverses P-glycoprotein-mediated multidrug resistance by affecting Pgp-substrate complexes.

Wang-Fun Fong; Chi-Keung Wan; Guo-Yuan Zhu; Apurba Chattopadhyay; Saibal Dey; Zhongzhen Zhao; Xiao-Ling Shen

Bioorganic & Medicinal Chemistry | 2008

Methoxylation of 3′,4′-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells

Wang-Fun Fong; Xiao-Ling Shen; Christoph Globisch; Michael Wiese; Guang-Ying Chen; Guo-Yuan Zhu; Zhi-Ling Yu; Anfernee Kai-Wing Tse; Yingjie Hu

Experimental Cell Research | 2007

1,25-Dihydroxyvitamin D3 induces biphasic NF-κB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IκB

Anfernee Kai-Wing Tse; Chi-Keung Wan; Xiao-Ling Shen; Guo-Yuan Zhu; Hon-Yeung Cheung; Mengsu Yang; Wang-Fun Fong

Bioorganic & Medicinal Chemistry | 2006

(+/-)-3'-O, 4'-O-dicynnamoyl-cis-khellactone, a derivative of (+/-)-praeruptorin A, reverses P-glycoprotein mediated multidrug resistance in cancer cells.

Xiao-Ling Shen; Guang-Ying Chen; Guo-Yuan Zhu; Wang-Fun Fong

Archive | 2007

Reversing agent for drug-fast during treating tumor with multiple medicines

Yingjie Hu; Xiao-Ling Shen; Honglong Lu; Linchun Fu

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Wang-Fun Fong

Hong Kong Baptist University

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Chi-Keung Wan

City University of Hong Kong

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Guo-Yuan Zhu

Hong Kong Baptist University

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Anfernee Kai-Wing Tse

City University of Hong Kong

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Mengsu Yang

City University of Hong Kong

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Yingjie Hu

Guangzhou University of Chinese Medicine

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Cheng Wang

City University of Hong Kong

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Hon-Yeung Cheung

City University of Hong Kong

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J. X. Zhang

University of Hong Kong

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Guang-Ying Chen

Hainan Normal University

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