Xiao-Na Wang
Zhengzhou University
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Publication
Featured researches published by Xiao-Na Wang.
Organic Letters | 2016
Jingyi Zhang; Qingshuang Zhang; Biao Xia; Jie Wu; Xiao-Na Wang; Junbiao Chang
We present a metal-free [2 + 2 + 2] cycloaddition of ynamides with nitriles that enables highly efficient access to 2,4-diaminopyridines. This catalytic protocol is more environmentally friendly and allows for a concomitant construction of C-C and C-N bonds between ynamides and nitriles, exhibiting excellent chemoselectivity, regioselectivity, and wide functional groups tolerance.
Organic Letters | 2015
Hongxu Liu; Yanyan Yang; Shen Wang; Jie Wu; Xiao-Na Wang; Junbiao Chang
A Sn(IV)-promoted annulation reaction of ynamides is described for the efficient synthesis of 3-substituted 2-aminochromones under mild conditions. This novel method allows for a concomitant construction of C-C and C-O bonds between ynamides and 2-methoxyaroyl chlorides by a tandem Friedel-Crafts acylation/oxo-Michael addition/elimination strategy.
Medicinal Chemistry Research | 2017
Lijiao Zhang; Zechun Wang; Ting Ren; Hongxu Liu; Xiao-Na Wang; Ruiyong Wang; Junbiao Chang
The fat mass and obesity-associated protein is a potential target for anti-obesity medicines. In the present work, the interaction between our synthesized 3-substituted 2-aminochromones and fat mass and obesity-associated protein were investigated using fluorescence spectroscopy, ultraviolet–visible spectroscopy and molecular modeling approach. Fluorescence spectroscopy showed that the fluorescence of fat mass and obesity-associated protein can be quenched by these compounds with a static quenching procedure. In addition, the thermodynamic parameters obtained from the fluorescence data showed that the hydrophobic force played a major role in stabilizing the complexes. Ultraviolet–visible spectroscopy, synchronous fluorescence spectroscopy and three-dimensional fluorescence spectroscopy indicated that these compounds can induce some conformational changes of fat mass and obesity-associated protein.
Chemical Communications | 2016
Hongxu Liu; Yanyan Yang; Jie Wu; Xiao-Na Wang; Junbiao Chang
Organic Letters | 2016
Yanyan Yang; Hongxu Liu; Cheng Peng; Jie Wu; Jingyi Zhang; Yan Qiao; Xiao-Na Wang; Junbiao Chang
Chemical Communications | 2018
Jingyi Zhang; Siqi Li; Yan Qiao; Cheng Peng; Xiao-Na Wang; Junbiao Chang
Archive | 2016
Yanyan Yang; Hongxu Liu; Cheng Peng; Jie Wu; Jingyi Zhang; Yan Qiao; Xiao-Na Wang; Junbiao Chang
Archive | 2016
Yanyan Yang; Hongxu Liu; Cheng Peng; Jie Wu; Jingyi Zhang; Yan Qiao; Xiao-Na Wang; Junbiao Chang
Archive | 2016
Yanyan Yang; Hongxu Liu; Cheng Peng; Jie Wu; Jingyi Zhang; Yan Qiao; Xiao-Na Wang; Junbiao Chang
Archive | 2016
Yanyan Yang; Hongxu Liu; Cheng Peng; Jie Wu; Jingyi Zhang; Yan Qiao; Xiao-Na Wang; Junbiao Chang