Xiao-Peng Liu

A Rapid Parallel Synthesis of 2-Dialkylamino-4H-imidazolin-4-ones

Abstract 2-Dialkylamino-4H-imidazolin-4-ones 6 were rapidly synthesized by a solution-phase parallel synthetic method, which includes Aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various aliphatic secondary amine in a parallel fashion.

NEW EFFICIENT SYNTHESIS OF 2-ALKYLTHIO-5-BENZYLJDENE-4H-IMIDAZOLIN-4-ONES

4H-Imidazolin4ones are important heterocycles having biological and pharmaceutical activities,1-6 and some 2-alkylthioimidazolinones show significant fungicidal a~tivities..~ However, most of the 2-alkylthioimidazolinones reported are of the 5,5-disubstituted type and were generally synthesized from corresponding a-aminoacetic acid9J0 (Eq. I). Unfortunately, 5benzylidene-2-alkylthioimidazolinones cannot be prepared by this general method for the

A Facile and Selective Synthesis of 2-Alkylamino-4(3H)-quinazolinones

Abstract The carbodiimides 2, obtained from aza–Wittig reactions of iminophosphorane 1 with aromatic isocyanates, reacted with aliphatic primary amines to give mainly 2-alkylamino-4(3H)-quinazolinones 4 with unusual selectivity.

A FACILE SYNTHESIS OF DERIVATIVES OF 4-ARYL-1,3,2-DIOXAPHOSPHORINANE-2-SULFIDE VIA LAWESSON'S REAGENT

Abstract The derivatives of 4-aryl-1,3,2-dioxaphosphorinane-2-sulfide, namely, 4-aryl-5,5-dimethyl-1,3,2-dioxaphosphorinane-2-sulfides (6) were synthesized in moderate yields by the cyclization reaction of 1-aryl-2,2-dimethyl-1,3-propanediols(5) with Lawessons reagent using acetonitrile as a solvent. 8-Membered cyclic trithiopyrophosphonates (7) were isolated as side-products.

A novel route to spiro phosphorus-heterocycle via Lawesson's reagent

ABSTRACT 2-Aryl-spiro-[5,5]-1,3,2-dioxaphosphorinane-2-sufides were prepared by the cyclization reaction of Lawessons reagent with pentaerythritol and monobenzalpentaerythritol, respectively.

Application of Lawesson'S Reagent in Syntheses of Biologically Active Phosphorus Heterocycles

Abstract The reactions of Lawessons reagent-2.4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide, with long-chain 1 - glycerin rnonoethers, 3-mercapto-4-amino-1,2,4-triazoles, 1,3-disubstituents glycinamides, and 2-methyl-1,3-butadiene have been investigated and found to form cyclic analogues 1, fused heterocycles 2, 5-membered phosphorus rings 3, and 6-membered heterocycle 4, respectively, in moderate yield. The preliminary biological screening tests for these rings showed that they possess significant selective herbicidal activity against rape.

A DIRECT SYNTHESIS OF 2-ALKOXY-4H-IMIDAZOL-4-ONES

2-Alkoxy-4H-imidazol-4-ones 4 were synthesized by aza-Wittig reaction of iminophosphorane _1 with phenyl isocynate to give carbodiimide 2 and subsequent reaction of 2 with ROH in the presence of catalytic RONa.

A Facile Synthesis of Fused Phosphorus-Heterocycle with Bioactivity via Lawesson's Reagent

A convenient one-pot synthesis of fused phosphorus-heterocycles with biological activity via the cyclization reactions of Lawessons reagent with bifunctional substrates is reported.

A CONVENIENT SYNTHESIS OF DERIVATIVES OF 1,3,2- DIOXAPHOSPHOCANE-2-SULFIDE WITH BIOACITIVITY VIA LAWESSON'S REAGENT

Lawessons reagent, 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disufide, reacted with the substituted 1,5-bisphenol 1 to afford derivatives of l,3,2-dioxaphosphocane-2-sulfide 2, which were found to possess selective herbicidal activity against rape.

SYNTHESIS OF 1,3-DIARYL-1,3,2-DIAZAPHOSPHOLIDIN-4-THIONE-2-SULFIDES VIA LAWESSON'S REAGENT

Abstract 2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawessons Reagent, LR), was treated with N,N′-diaryl glycinamides (1) in anhydrous toluene as a solvent at 100°C to form 1,3-diaryl-1,3,2-ciazaphospholidin-4-thione-2-sulfides (2) Compatible analytical and spectroscopic data were obtained for all the new compounds. A mechanism was proposed to explain the formation of compound 2f. The biological activity of the title products was also tested and some of them showed good herbicidal activity.