Xiaochun Yu
Wenzhou University
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Publication
Featured researches published by Xiaochun Yu.
Organic Letters | 2013
Erlei Zhang; Haiwen Tian; Sendong Xu; Xiaochun Yu; Qing Xu
Abundant and cheap iron readily catalyzed the aerobic oxidative reactions of primary amines, secondary amines, benzylamines with anilines, and alcohols with amines by directly using air as the economic and safe oxidant, providing several direct, practical, and greener approaches for the preparation of useful imines.
Chemical Communications | 2011
Lan Jiang; Luolu Jin; Haiwen Tian; Xueqin Yuan; Xiaochun Yu; Qing Xu
By ligand, TEMPO, and base screening, we developed a mild and green one-pot imine synthesis from alcohols and amines via a low-loading palladium-catalyzed tandem aerobic alcohol oxidation-dehydrative condensation reaction that can be readily carried out in open air at room temperature.
Organic Letters | 2011
Xiaochun Yu; Chuanzhi Liu; Lan Jiang; Qing Xu
By simply running the reactions under air and solvent-free conditions using catalytic amounts of manganese dioxide, a practical and efficient N-alkylation method for a variety of sulfonamides and amines using alcohols as green alkylating reagents was developed.
Journal of Organic Chemistry | 2011
Chuanzhi Liu; Shiheng Liao; Qiang Li; Sunlin Feng; Qing Sun; Xiaochun Yu; Qing Xu
The thermodynamically unfavorable anaerobic dehydrogenative alcohol activation to aldehydes and hydridometal species is found to be the bottleneck in metal-catalyzed N-alkylations due to a general and unnoticed catalyst deactivation by amines/amides. Thus, different from the anaerobic dehydrogenation process in borrowing hydrogen or hydrogen autotransfer reactions that require noble metal complexes or addition of capricious ligands for catalyst activation, the water-producing, exothermic, metal-catalyzed aerobic alcohol oxidation is thermodynamically more favorable and the most effective and advantageous aldehyde generation protocol. This leads to a general and advantageous air-promoted metal-catalyzed aerobic N-alkylation methodology that effectively uses many simpler, less expensive, more available, and ligand-free metal catalysts that were inactive under typical anaerobic borrowing hydrogen conditions, avoiding the use of preformed metal complexes and activating ligands and the exclusive requirement of inert atmosphere protection. This aerobic method is quite general in substrate scope and tolerates various amides, amines, and alcohols, revealing its potentially broad utilities and interests in academy and industry. In contrast to the commonly accepted borrowing hydrogen mechanism, based on a thorough mechanistic study and supported by the related literature background, a new mechanism analogous to the relay race game that has never been proposed in metal-catalyzed N-alkylation reactions is presented.
Green Chemistry | 2016
Qing Xu; Huamei Xie; Erlei Zhang; Xiantao Ma; Jianhui Chen; Xiaochun Yu; Huan Li
Using only catalytic amounts of alkyl halides in the reactions of poor nucleophilic amines/amides and alcohols led to a selective Hofmann N-alkylation reaction catalytic in alkyl halides, providing a practical and efficient method for the practical synthesis of mono- or di-alkylated amines/amides in high selectivities. This new method avoids the use of large amounts of bases, alkyl halides, and solvents, and generates water as the only byproduct. Preliminary mechanistic studies showed that alkyl halides are key intermediates/catalysts regeneratable in the reaction cycle.
Advanced Synthesis & Catalysis | 2012
Haiwen Tian; Xiaochun Yu; Qiang Li; Jianxin Wang; Qing Xu
Organic and Biomolecular Chemistry | 2012
Shiheng Liao; Kangkang Yu; Qiang Li; Haiwen Tian; Zhengping Zhang; Xiaochun Yu; Qing Xu
Tetrahedron Letters | 2013
Bo Huang; Haiwen Tian; Shoushuai Lin; Meihua Xie; Xiaochun Yu; Qing Xu
Organic and Biomolecular Chemistry | 2012
Qiang Li; Songjian Fan; Qing Sun; Haiwen Tian; Xiaochun Yu; Qing Xu
Chinese Journal of Chemistry | 2012
Xiaochun Yu; Lan Jiang; Qiang Li; Yuanyuan Xie; Qing Xu