Xiaoming Qiu

Thymoma With Pure Red Cell Aplasia and Good's Syndrome

Thymoma patients with pure red cell aplasia (PRCA) or hypogammaglobulinemia (Goods syndrome) are rare, whereas those with both PRCA and Goods syndrome are even rarer. Here we present the case report of a 70-year-old woman with invasive thymoma and simultaneous PRCA and Goods syndrome, who achieved complete PRCA remission after thymectomy.

Primary Leiomyoma of the pleura.

Primary leiomyoma of the pleura is extremely rare. A 45-year-old man presented with a complaint of right chest pain. Chest computed tomography demonstrated a solid, round pleural mass in the right anterior chest wall. The mass was completely resected, and histopathological examination revealed a localized primary pleural leiomyoma. The patient was followed and has been disease-free for over 15 months. This is the first report of primary leiomyoma of the pleura in China. A review of the literature on primary leiomyoma of the pleura is presented.

[Lentivirus-mediated stable silencing of nm23-H1 gene in lung cancer cells and the influence on biological behavior].

背景与目的 nm23-H1基因是重要的肿瘤转移抑制基因。前期研究发现利用化学合成的小干扰RNA（small interfering RNA, siRNA）抑制nm23-H1基因的表达可明显增强肺癌细胞的侵袭力。为了进一步研究nm23-H1基因沉默后的分子生物学机制，本研究利用慢病毒介导的短发夹RNA（short hairpin RNA, shRNA）建立nm23-H1基因稳定沉默的肺癌细胞株。 方法 将表达特异性抑制nm23-H1基因shRNA的慢病毒转染人大细胞肺癌细胞株NL9980和肺腺癌细胞株A549，通过嘌呤霉素筛选出稳定转染细胞株。逆转录PCR、定量PCR及Western blot法检测nm23-H1基因表达，并通过shRNA抵抗的nm23-H1基因重组质粒转染拯救实验验证，侵袭小室实验检测侵袭力改变。 结果 逆转录PCR、定量PCR和Western blot法检测稳定转染细胞株NL9980-99和A549-99中nm23-H1基因在mRNA和蛋白水平表达均明显降低；shRNA抵抗的nm23-H1基因重组质粒转染拯救实验重现nm23-H1的正常表达；侵袭小室实验显示NL9980-99和A549-99细胞侵袭力明显增强。 结论 成功建立nm23-H1基因稳定沉默的人大细胞肺癌细胞株NL9980-99和人肺腺癌细胞株A549-99，nm23-H1基因沉默后使NL9980-99和A549-99细胞的侵袭力明显增强。

Primary diffuse large B-cell lymphoma of the chest wall: a case report

Reports of primary diffuse large B-cell lymphomas of the chest wall are extremely rare in the literature. We report the case of a 62-year-old Chinese woman presenting with left-sided chest pain. A computed tomography scan showed a solid, round mass in the left anterior chest wall, involving the second and third costal cartilages. Complete resection and reconstruction of the chest wall was performed. The histological and immunohistochemical features of the mass were used to diagnose a primary diffuse large B-cell lymphoma.

Intrapulmonary unicentric Castleman disease mimicking peripheral pulmonary malignancy

Castleman disease, also known as angiofollicular lymph node hyperplasia, can manifest as a unicentric or multicentric disorder. Intrapulmonary Castleman disease is very rare. Here, we present a patient with intrapulmonary Castleman disease who underwent left upper pulmonary lobectomy for suspected early lung cancer. The histopathologic diagnosis of the lobar mass was hyaline‐type Castleman disease. The patient has remained well after surgery, showing no local recurrence or distant disease during a two‐year follow‐up period. Although unicentric Castleman disease originating in the lung is rare, it should be considered in the differential diagnosis of primary pulmonary malignant tumors.

Primary mediastinal pleomorphic liposarcoma involving the superior vena cava

Primary mediastinal liposarcomas are extremely rare. They are primarily diseases of adults; however, they may be encountered in children. They are characterized by their large size and variable histologic subtypes, which correlate with clinical behavior and prognosis. Although the overall prognosis is poor, it is dependent upon the histologic subtype and completeness of surgical excision. Herein we present a case of a primary mediastinal pleomorphic liposarcoma in a 49‐year‐old male who received an en‐bloc resection and superior vena cava replacement with Gortex graft. The patient has been disease‐free after surgery for over 14 months.

[Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer.].

BACKGROUND It has been proven that heparanase and Ki-67 had relationship with occurrence and metastasis in lung cancer. The aim of this work was to investigate the expressions of heparanase and Ki-67 and to explore their clinical significance and mutual relations in non-small cell lung cancer (NSCLC). METHODS Immunohistochemical method was used to detect the heparanase and Ki-67expression in the routinely paraffin-embedded sections of surgical specimen of 70 cases with NSCLC and 20 ones with normal lung tissues. RESULTS Heparanase and Ki-67 were highly expressed in lung cancer tissues (72.9% and 85.7%) while negative in epithelia of normal lung tissues. The expression of heparanase was significantly correlated with TNM stage (P=0.044) and lymphatic metastasis (P=0.001). The expression of Ki-67 was significantly correlated with tumor size (P=0.03) and histology type (P=0.001) and differentiation (P=0.01) and lymphatic metastasis (P=0.01) and TNM stage (P=0.043). The expression of heparanase and Ki-67 was no significant difference (P=0.323). CONCLUSIONS Heparanase and Ki-67 were involved in the occurrence and development of lung cancer and they may predict patients prognosis, while the expression of heparanase and Ki-67 had no association with NSCLC, which may contribute to the different mechanisms involved in tumor occurrence and development.

Giant Primary Chondroma of the Lung: A Case Report

患者,女,40岁,查体发现右下肺肿物1周入院。 既往体健。体格检查:体温正常,脉搏、血压、呼吸 均无异常。胸壁无压痛,双肺呼吸运动对称,触觉语颤 对称,叩诊呈清音,听诊双肺呼吸音稍粗,未闻及干、 湿啰音。入院后CT检查:右下肺后基底段可见大小约 6.4 cm×5.7 cm×7.5 cm的不规则软组织肿块,内可见多发 斑片钙化,形态不规则,肿块与局部胸膜粘连,未见明 显强化(图1)。完善术前检查后于2010年8月17日在全 麻下行剖胸探查,术中见包块位于右肺下叶后段,突出 于肺表面,不规则分叶,被覆脏层胸膜及少量肺组织, 与周围组织无粘连,质硬。行右肺下叶楔形切除术,完 整切除肿物。包块为灰白灰褐不规则组织,大小6.5 cm× 6.0 cm×5.0 cm,有多个结节状突起,切面质地较硬,灰 白色,半透明状,软骨样(图2)。镜检:瘤体由较成 熟的软骨细胞构成,周围为软骨基质包绕,呈不规则分 叶状(图3)。病理诊断:右下肺软骨瘤,局部生长活 跃。患者术后10天治愈出院。