Xiaorong Li

Could microbe stimulated maggots become a targeted natural antibiotics family

Maggot debridement therapy plays an important role in treatment of diabetic foot ulcers and other chronic infectious wounds, cause of this is its extremely low drug resistance. However, the microbe stimulated maggot, we may call it a derivative of normal sterile maggot, could exhibit stronger bacterial or bactericidal effects. Methods of the pretreatment on maggot was different germ solution were artificially mixed and added with originally sterile maggots, the novel secretions were collected. Some of this have been demonstrated by plate test and telescope analysis. Thus, we hypothesize that maggot especially the larvae of Lucilia sericata was conducted as the germ irritant receptor, and diverse germs interacted with it, at last, novel secretions/excretions we got will offer a great help to the general surgery clinicians as well as researchers who are interested in novel antibiotics discovery.

A potential material to cut down infection caused by application of artificial muscles.

Artificial muscles are so important that can be used to cure prosthetic limbs. A new kind of taurine Schiff base sodium was synthesized by a series of chemical reactions, which may be applied to strengthen antibacterial activity of artificial muscle. The bioactivity of this material was screened by cytotoxicity test, antibacterial test, and thermal gravity test and so on. All results told us that this material had low toxicity, high antibacterial activity and thermal stability. Combine our deep studies on pharmacological activity of the active material with our knowledge on artificial muscles; we want to know if we can put this material into the content of artificial muscle, in order to strengthen its antimicrobial activity, so that the pains of the patients who were applied artificial muscle would be relieved.

N′-(2-Chloro­benzyl­idene)-4-methyl­benzohydrazide

In the title compound, C15H13ClN2O, the molecule displays a trans conformation with respect to the C=N bond. The two aromatic rings form a dihedral angle of 12.0 (3)°. In the crystal, molecules are connected via N—H⋯O hydrogen bonds into chains propagating along the c-axis direction.