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Dive into the research topics where Xie Zixin is active.

Publication


Featured researches published by Xie Zixin.


Phosphorus Sulfur and Silicon and The Related Elements | 2014

Synthesis, Antitumor Activity, and SAR of N-Substituted γ-Aminopropylsilatrane Derivatives

Guo Ping; Wang Yuewu; Luo Xin-Tong; Qi Xiaolu; Hou Le-Ping; Xie Zixin; Ye Faqing

Abstract γ-Aminopropylsilatrane has been reported to possess biological activity against tumor cancer cells with low cytotoxicity in many kinds of silatranes. So some N-substituted γ-aminopropylsilatrane derivatives were synthesized and assayed by a primary anticancer screening against HT-29, Hela, and MDAMB435 cells by the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. The structures of these derivatives were confirmed by 1H NMR, electrospray ionization-mass spectrometry, and elemental analysis. The structure–activity relationship showed that the N-substituted derivatives exhibit better activity in which the γ-amino group of the silatrane is connected with stronger electron-withdrawing groups. GRAPHICAL ABSTRACT


Archive | 2014

2-Amino-8-substituted guanine derivative with IKK-beta as target spot, as well as application and preparation method thereof

Ye Faqing; Guo Ping; Liu Jianmin; Xie Zixin; Wang Yuewu; Song Xiaoqin; Chen Liangfang


Chinese Journal of Medicinal Chemistry | 2007

Synthesis of 3,7,10-trimethyl-γ-aminopropyl silatrane derivatives

Xie Zixin


Archive | 2017

9-subsituted-N-(2-chlorobenzyl)purine-6-amine derivative, as well as preparation method and application thereof

Ye Faqing; Guo Ping; Zhang Huan; Lyu Handeng; Xie Zixin; Lin Dan; Zhang Yuan; Wang Xuebao; Zhang Jinsan; Guo Qiang


Archive | 2017

6-substituted-9H-purine derivative and preparation method and application thereof

Ye Faqing; Guo Ping; Zhang Huan; Lyu Handeng; Xie Zixin; Lin Dan; Zhang Yuan; Wang Xuebao; Zhang Jinsan; Guo Qiang


Archive | 2017

6-chloro-2-aminobenzothiazole derivative as well as preparation method and application thereof

Ye Faqing; Guo Ping; Zhang Zaikui; Luo Lu; Pan Yaqian; Xie Zixin; Lin Dan; Zhang Yuan; Wang Xuebao; Zhang Jinsan; Guo Qiang


Archive | 2017

4-bormine-N-3, 5-dimethoxy phenyl benzamide derivative acting on FGFR1 and preparation method and application of 4-bormine-N-3, 5-dimethoxy phenyl benzamide derivative

Ye Faqing; Shen Guoliang; Lyu Handeng; Luo Lu; Zhang Yuan; Wang Xuebao; Xie Zixin


Archive | 2016

6-substitued aminopurine compound acting on EGFR sensitive mutation kinase EGFR and EGFR and application of 6-substitued aminopurine compound

Ye Faqing; Wang Yu; Wang Yuewu; Yu Shufang; Chen Di; Chen Liangfang; Song Xiaoqin; Xie Zixin; Liang Guang; Li Xiaokun; Liu Zhiguo; Lin Dan


Archive | 2016

Traditional Chinese medicine decocting machine based on annular steam pipelines and annular heating rails

Zhang Meiling; Wang Xianchuan; Sun Fa; Xie Zixin; Lin Dan; Wang Xuebao; Zhang Yuan; Deng Mingjie; Gao Hongchang; Jin Litai


Archive | 2015

Tetrahydrobenzothieno[2,3-d]aminopyrimidine derivatives for FGFR1, and preparation method and application thereof

Ye Faqing; Chen Di; Xie Zixin; Liu Zhiguo; Lin Dan; Zhang Jinsan; Wang Xuebao; Zhang Yuan; Liang Guang; Li Xiaokun; Wang Yu; Yu Shufang

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Ye Faqing

Wenzhou Medical College

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Guo Ping

Wenzhou Medical College

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Wang Yuewu

Wenzhou Medical College

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Liang Guang

Wenzhou Medical College

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Hou Le-Ping

Wenzhou Medical College

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Li Xiaokun

Chinese Academy of Sciences

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Luo Xin-Tong

Wenzhou Medical College

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Qi Xiaolu

Wenzhou Medical College

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