Xinbao Li
North China University of Water Conservancy and Electric Power
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Publication
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The Journal of Chemical Thermodynamics | 2017
Xinbao Li; Yang Cong; Wentian Li; Pengyao Yan; Hongkun Zhao
Abstract The equilibrium solubility of ribavirin in solvent mixtures of {methanol (1)+water (2)}, {n-propanol (1)+water (2)}, {acetonitrile (1)+water (2)} and {1,4-dioxane (1)+water (2)} was determined experimentally by using isothermal dissolution equilibrium method within the temperature range from (278.15 to 318.15) K under atmospheric pressure (101.1kPa). At the same temperature and mass fraction of methanol (n-propanol, acetonitrile or 1,4-dioxane), the mole fraction solubility of ribavirin is greater in (methanol+water) than in the other three solvent mixtures. The preferential solvation parameters were derived from their thermodynamic solution properties by means of the inverse Kirkwood–Buff integrals. The preferential solvation parameters for methanol, n-propanol, acetonitrile or 1,4-dioxane (δx 1,3) were negative in the four solvent mixtures with a very wide compositions, which indicated that ribavirin was preferentially solvated by water. Temperature had little effect on the preferential solvation magnitudes. The higher solvation by water could be explained in terms of the higher acidic behaviour of water interacting with the Lewis basic groups of the ribavirin. Besides, the solubility of the drugs was mathematically represented by using the Jouyban-Acree model, van’t Hoff-Jouyban-Acree model and Apelblat-Jouyban-Acree model obtaining average relative deviations lower than 1.57% for correlative studies. It is noteworthy that the solubility data presented in this work contribute to expansion of the physicochemical information about the solubility of drugs in binary solvent mixtures and also allows the thermodynamic analysis of the respective dissolution and specific solvation process.
The Journal of Chemical Thermodynamics | 2017
Xinbao Li; Chao Cheng; Yang Cong; Cunbin Du; Hongkun Zhao
Journal of Molecular Liquids | 2017
Xinbao Li; Mingju Wang; Cunbin Du; Yang Cong; Hongkun Zhao
The Journal of Chemical Thermodynamics | 2017
Xinbao Li; Cunbin Du; Yang Cong; Hongkun Zhao
The Journal of Chemical Thermodynamics | 2017
Xinbao Li; Chao Cheng; Yang Cong; Cunbin Du; Hongkun Zhao
The Journal of Chemical Thermodynamics | 2017
Xinbao Li; Mingju Wang; Yang Cong; Cunbin Du; Hongkun Zhao
The Journal of Chemical Thermodynamics | 2017
Xinbao Li; Mingju Wang; Cunbin Du; Yang Cong; Hongkun Zhao
The Journal of Chemical Thermodynamics | 2017
Xinbao Li; Yang Cong; Jian Wang; Cunbin Du; Shuo Han; Long Meng; Hongkun Zhao
The Journal of Chemical Thermodynamics | 2017
Xinbao Li; Mingju Wang; Cunbin Du; Yang Cong; Hongkun Zhao
The Journal of Chemical Thermodynamics | 2017
Xinbao Li; Yu Liu; Jiao Chen; Gaoquan Chen; Hongkun Zhao
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North China University of Water Conservancy and Electric Power
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