Xiu-E Lu
Zhejiang University
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Featured researches published by Xiu-E Lu.
Gynecological Endocrinology | 2010
Dan Zhang; Yi-Min Zhu; Huijuan Gao; Biao Zhou; Run-Ju Zhang; Ting-Ting Wang; Guo-Lian Ding; Fan Qu; He-Feng Huang; Xiu-E Lu
Objective. To explore the effects of overweight and obesity on the outcomes of in vitro fertilisation (IVF) in Chinese infertile patients. Study design. A retrospective cohort study was carried out in 2222 normal weight (18.5 ≤ BMI < 25), 379 overweight (25 ≤ BMI < 30) and 27 obese (BMI ≥ 30) women who underwent their first IVF cycles between 2002 and 2008. Cycle characteristics and IVF outcomes were analysed. Results. Obese women required significantly higher dose of rFSH (3272 IU vs. 2587 IU, p < 0.001) and days of stimulation (11.89 ± 4.57 vs. 10.42 ± 2.03, p < 0.001), but exhibited less oocytes retrieved and significantly lower fertilisation rate (54.1% vs. 61.1%, p < 0.001) than normal weight women. Compared with normal weight women, overweight women displayed significantly less oocytes retrieved (12.98 ± 6.91 vs. 14.49 ± 7.96, p < 0.001), lower fertilisation rate (60.8 ± 23.3 vs. 61.1 ± 23.0, p < 0.001), less cleavaged embryos (7.55 ± 4.86 vs. 8.67 ± 5.90, p < 0.001), less high-grade embryos (4.65 ± 3.96 vs. 5.59 ± 4.81, p < 0.001) and cryopreserved embryos (4.44 ± 4.55 vs. 5.49 ± 5.55, p < 0.001). All parameters of pregnancy outcomes, including pregnancy rate, miscarriage rate and live birth rate, were comparable among three groups. Conclusions. Overweight and obesity are related with impared ovarian response, and negatively affect the outcomes of IVF.
The Journal of Clinical Endocrinology and Metabolism | 2014
Xiao-Ling Hu; Chun Feng; Xian-Hua Lin; Zi-Xing Zhong; Yi-Min Zhu; Ping-Ping Lv; Min Lv; Ye Meng; Dan Zhang; Xiu-E Lu; Fan Jin; Jian-Zhong Sheng; Jian Xu; He-Feng Huang
CONTEXT There are increasing concerns that a disrupted endocrine environment may disturb the growth of the fetus. Assisted reproductive technology (ART) situates gamete/embryo in a supraphysiological estradiol (E2) environment and, thus, provides an ideal model to investigate this problem. OBJECTIVE Our objective was to investigate whether the maternal high-E2 environment in the first trimester increases the risks of low birth weight (LBW) and small-for-gestational-age (SGA) birth. METHODS In total, 8869 singletons born after fresh embryo transfer (ET) (n = 2610), frozen ET (n = 1039), and natural conception (NC) (n = 5220) and their mothers were included. Birth weight, LBW, SGA, and maternal serum E2 levels were investigated. RESULTS The mean serum E2 levels of women undergoing fresh ET at 4 and 8 weeks of gestation were significantly higher than those of the women undergoing frozen ET and the women with NC (P < .01). Serum E2 levels of women undergoing fresh ET at 4 and 8 weeks of gestation were positively correlated to those on the day of human chorionic gonadotropin (hCG) administration (r = 0.5 and r = 0.4, respectively; P < 0.01). The birth weight after fresh ET was significantly lower than that after frozen ET and NC (P < 0.01), with increased incidence of LBW and SGA (P < .05). Furthermore, in the fresh ET group, singletons of mothers with high E2 levels (≥10460 pmol/L on the day of hCG administration) had higher risks of LBW (P < .01) and SGA (P < .01) than those with low E2 levels, and maternal serum E2 level on the day of hCG administration negatively correlated with the birth weight (P < .01). CONCLUSIONS The maternal high-E2 environment in the first trimester is correlated with increased risks of LBW and SGA. Evaluation of serum E2 before ET should be adopted to reduce the possibility of high E2 exposure to gamete/embryo.
Human Reproduction | 2010
Fan Qu; Fang-Fang Wang; Xiu-E Lu; Min-Yue Dong; Jian-Zhong Sheng; Ping-Ping Lv; Guo-Lian Ding; Bi-Wei Shi; Dan Zhang; He-Feng Huang
BACKGROUND The present study was designed to evaluate whether the alteration of aquaporin-9 (AQP-9) expression in granulosa cells (GCs) of patients with polycystic ovary syndrome (PCOS) was associated with the hyperandrogenism in follicular fluid (FF). METHODS We recruited infertile women with PCOS (n = 14) and infertile women with tubal blockage (controls, n = 31) for this study. We examined total testosterone (TT), free androgen index (FAI), sex hormone-binding globulin (SHBG), FSH, LH and estradiol in FF. Real-time PCR and western blotting were performed to assess AQP-9 expression in GCs, including effects of dihydrotestosterone (DHT) in vitro. RESULTS AQP-9 protein was localized in the nucleus, cytoplasm and cell membrane of the human GCs. The TT, FAI and LH levels were all higher, and SHBG levels lower, in the FF of women with PCOS versus controls (P = 0.0145, 0.0001, 0.0191, 0.0001, respectively). AQP-9 mRNA level in GCs of patients with PCOS was tightly correlated with the TT, SHBG levels and FAI in FF (P = 0.0020, 0.0001, 0.0020, respectively). In vitro, DHT (10(-9) mol/l) decreased AQP-9 mRNA (lowest at 12 h) and protein levels in control GCs (P = 0.0005, 0.0247, respectively). The inhibitory effect of DHT on AQP-9 mRNA was attenuated by LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor (P = 0.0013). Fifty micromolar 4-(hydroxymercuri) benzoic acid sodium salt (PMB) and 10(-9) mol/l DHT blunted the swelling of GCs in hypotonic medium, respectively (P = 0.0350, 0.0027). CONCLUSION Hyperandrogenism in FF of women with PCOS inhibited AQP-9 in GCs through the PI3K pathway.
Ceramics International | 2002
Xiao-Ling Hu; X. M. Chen; Xiu-E Lu
Abstract Ceramics in the Pb(Mg 1/3 Nb 2/3 )O 3 –CaTiO 3 –Bi 4 Ti 3 O 12 pseudo-ternary system were investigated to search for new temperature-stable dielectrics for high frequency applications. A near-zero temperature coefficient was obtained combined with a high dielectric constant (124) and a low dielectric loss (10 −3 at 1 MHz) where a complex phase constitution was observed. The dielectric properties were significantly sensitive to the sintering conditions due to the variation of phase constitution.
Human Reproduction | 2007
Yan-Ting Wu; Li Tang; Jie Cai; Xiu-E Lu; Jian Xu; Xiao-Ming Zhu; Qiong Luo; He-Feng Huang
Fertility and Sterility | 2007
Jie Cai; Hang-ying Lou; Min-Yue Dong; Xiu-E Lu; Yi-Min Zhu; Huijuan Gao; He-Feng Huang
The Journal of Clinical Endocrinology and Metabolism | 2007
Meigen Li; Guo-Lian Ding; Xi-Jing Chen; Xi-Ping Lu; Li-Jun Dong; Min-Yue Dong; Xiaofu Yang; Xiu-E Lu; He-Feng Huang
Journal of Zhejiang University-science B | 2005
Xiu-E Lu; He-Feng Huang; Meigen Li; Yi-Min Zhu; Yu-li Qiang; Min-Yue Dong
Fertility and Sterility | 2006
Xiu-E Lu; Weixuan Ning; Min-Yue Dong; Ai-Xia Liu; Fan Jin; He-Feng Huang
Fertility and Sterility | 2009
Dan Zhang; Yi-Min Zhu; Huijuan Gao; Ting-Ting Wang; He-Feng Huang; Xiu-E Lu