Xiuxiu Li
Wuhan University
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Publication
Featured researches published by Xiuxiu Li.
Angewandte Chemie | 2016
Cai You; Biao Wei; Xiuxiu Li; Yusheng Yang; Yue Liu; Hui Lv; Xumu Zhang
Excellent enantioselectivities (up to 97 % ee) and diastereoselectivities (up to >99:1 d.r.) have been achieved in the desymmetrization of cyclopentenes by catalytic hydroformylation. This novel methodology provides an efficient and concise synthetic route to chiral cyclopentane carboxaldehydes. The key intermediate, (1S,3S)-(3-hydroxymethyl)cyclopentanol, for the synthesis of carbocyclic-ddA was obtained in three steps.
Organic Letters | 2017
Xiuxiu Li; Cai You; Shuailong Li; Hui Lv; Xumu Zhang
The nickel-catalyzed asymmetric hydrogenation of β-(acylamino)acrylates has been developed, affording chiral β-amino acid derivatives with excellent yields (95-99% yield) and enantioselectivities (97-99% ee). With the Ni-Binapine system, high enantioselectivities (98-99% ee) have also been obtained in the hydrogenation of Z/E isomeric mixtures of β-alkyl and β-aryl β-(acylamino)acrylates. The synthesis of chiral β-amino acid derivatives on a gram scale has also been achieved with 0.2 mol % catalyst loading.
Journal of the American Chemical Society | 2018
Cai You; Shuailong Li; Xiuxiu Li; Jialing Lan; Yuhong Yang; Lung Wa Chung; Hui Lv; Xumu Zhang
A series of novel hybrid phosphorus ligands were designed and applied to the Rh-catalyzed enantioselective anti-Markovnikov hydroformylation of unfunctionalized 1,1-disubstituted alkenes. By employing the new catalyst, linear aldehydes with β-chirality can be prepared with high yields and enantioselectivities under mild conditions. Furthermore, catalyst loading as low as 0.05 mol % furnished the desired product in good yield and undiminished selectivity, demonstrating the efficiency of this transformation in large-scale synthesis.
Nature Communications | 2018
Cai You; Xiuxiu Li; Yuhong Yang; Yusheng Yang; Xuefeng Tan; Shuailong Li; Biao Wei; Hui Lv; Lung Wa Chung; Xumu Zhang
Hydroformylation of 1,2-disubstituted alkenes usually occurs at the α position of the directing heteroatom such as oxygen atom and nitrogen atom. By contrast, to achieve hydroformylation on the β position of the heteroatom is a tough task. Herein, we report the asymmetric rhodium-catalyzed hydroformylation of 1,2-disubstituted alkenylsilanes with excellent regioselectivity at the β position (relative to the silicon heteroatom) and enantioselectivity. In a synthetic sense, we achieve the asymmetric hydroformylation on the β position of the oxygen atom indirectly by using the silicon group as a surrogate for the hydroxyl. Density functional theory (DFT) calculations are carried out to examine energetics of the whole reaction path for Rh/YanPhos-catalyzed asymmetric hydroformylation and understand its regioselectivity and enantioselectivity. Our computational study suggests that the silicon group can activate the substrate and is critical for the regioselectivity.Hydroformylation of 1,2-disubstituted alkenes usually occurs at the α position of the directing heteroatom. Here, the authors report the asymmetric rhodium-catalyzed hydroformylation of 1,2-disubstituted alkenylsilanes with excellent regioselectivity at the β position (relative to the silicon heteroatom) and enantioselectivity.
Advanced Synthesis & Catalysis | 2017
Xiuxiu Li; Cai You; Hailong Yang; Jinteng Che; Pengyu Chen; Yusheng Yang; Hui Lv; Xumu Zhang
Chemical Science | 2018
Xiuxiu Li; Cai You; Yusheng Yang; Yuhong Yang; Pan Li; Guoxian Gu; Lung Wa Chung; Hui Lv; Xumu Zhang
Synfacts | 2017
Mark Lautens; Ivan Franzoni; Xiuxiu Li; Cai You; Hailong Yang; J Che; P Chen; Yusheng Yang; Hui Lv; Xumu Zhang
Chemical Communications | 2017
Xiuxiu Li; Cai You; Yusheng Yang; Fangyuan Wang; Shuailong Li; Hui Lv; Xumu Zhang
Chemical Science | 2018
Yu-Qing Guan; Zhengyu Han; Xiuxiu Li; Cai You; Xuefeng Tan; Hui Lv; Xumu Zhang
Synfacts | 2017
Mark Lautens; Nicolas Zeidan; Xiuxiu Li; Cai You; Hailong Yang; J Che; P Chen; Yusheng Yang; Hui Lv; Xumu Zhang