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Xuemei Du

American Cyanamid

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Publication

Featured researches published by Xuemei Du.

Bioorganic & Medicinal Chemistry Letters | 2003

Synthesis and evaluation of 4-Anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade

Dan M. Berger; Minu Dutia; Dennis Powell; Biqi Wu; Allan Wissner; Diane H. Boschelli; M. Brawner Floyd; Nan Zhang; Nancy Torres; Jeremy I. Levin; Xuemei Du; Donald Wojciechowicz; Carolyn Discafani; Constance Kohler; Steven C. Kim; Larry Feldberg; Karen Collins; Robert Mallon

4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)]anilino-6,7-diethoxy-3-quinolinecarbonitrile (3) was identified as a MEK1 kinase inhibitor with exceptional activity against LoVo cells. The structure-activity relationships of the C-4 aniline substituents were explored, and water-solubilizing groups were added at the C-7 position to improve physical properties. Secondary cellular assays revealed that a compound possessing the appropriate aniline substituents inhibited MEK1 as well as MAPK phosphorylation, thereby acting as a dual inhibitor of the Ras-MAPK signaling cascade.

Bioorganic & Medicinal Chemistry | 2005

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Yonghan Hu; Jason Shaoyun Xiang; Martin J. DiGrandi; Xuemei Du; Manus Ipek; Leif M. Laakso; Jianchang Li; Wei Li; Thomas S. Rush; Jean Schmid; Jerauld S. Skotnicki; Steve Tam; Jennifer R. Thomason; Qin Wang; Jeremy I. Levin

International Immunopharmacology | 2004

Characterization of (2R, 3S)-2-({[4-(2-butynyloxy)phenyl]sulfonyl}amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-α converting enzyme

Yuhua Zhang; Martin Hegen; Jun Xu; James C. Keith; Guixian Jin; Xuemei Du; Terri Cummons; Barbara J. Sheppard; Linhong Sun; Yi Zhu; Vikram R. Rao; Qin Wang; Weixin Xu; Cheryl Nickerson-Nutter; Jay Gibbons; Jerry Skotnicki; Lih-Ling Lin; Jeremy I. Levin

Bioorganic & Medicinal Chemistry Letters | 2005

Synthesis and SAR of highly selective MMP-13 inhibitors

Jianchang Li; Thomas S. Rush; Wei Li; Dianne DeVincentis; Xuemei Du; Yonghan Hu; Jennifer R. Thomason; Jason Shaoyun Xiang; Jerauld S. Skotnicki; Steve Tam; Kristina Cunningham; Priya S. Chockalingam; Elisabeth A. Morris; Jeremy I. Levin

Bioorganic & Medicinal Chemistry Letters | 2003

Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates

Jeremy I. Levin; J.M. Chen; K. Cheung; D. Cole; C. Crago; E.Delos Santos; Xuemei Du; Gulnaz Khafizova; Gloria Jean Macewan; C. Niu; E.J. Salaski; Arie Zask; Terri Cummons; Amy Sung; J. Xu; Y. Zhang; W. Xu; Semiramis Ayral-Kaloustian; Guixian Jin; R. Cowling; Dauphine Barone; Kendall M. Mohler; Roy A. Black; Jerauld S. Skotnicki

Bioorganic & Medicinal Chemistry Letters | 2005

Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.

Jeremy I. Levin; J.M. Chen; L.M. Laakso; Mila T. Du; Xuemei Du; Aranapakam Mudumbai Venkatesan; Vincent Sandanayaka; Arie Zask; Jun Xu; Weixin Xu; Yuhua Zhang; Jerauld S. Skotnicki

Archive | 2000

Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors

Jeremy I. Levin; Arie Zask; Yansong Gu; Jay Donald Albright; Xuemei Du

Bioorganic & Medicinal Chemistry Letters | 2003

Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors

Arie Zask; Yansong Gu; J.D. Albright; Xuemei Du; M. Hogan; Jeremy I. Levin; J.M. Chen; Loran M. Killar; Amy Sung; John F. DiJoseph; Michele A. Sharr; Catherine E Roth; S. Skala; Guixian Jin; R. Cowling; Kendall M. Mohler; Dauphine Barone; Roy A. Black; C.J March; Jerauld S. Skotnicki

Bioorganic & Medicinal Chemistry Letters | 2005

Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors

Arie Zask; Joshua Kaplan; Xuemei Du; Gloria Jean Macewan; Vincent Sandanayaka; Nancy H. Eudy; Jeremy I. Levin; Guixian Jin; Jun Xu; Terri Cummons; Dauphine Barone; Semiramis Ayral-Kaloustian; Jerauld S. Skotnicki

Archive | 2004

Biaryl sulfonamides and methods for using same

Jeremy I. Levin; Thomas S. Rush; Frank Lovering; Yonghan Hu; Jianchang Li; Wei Li; Jun Jun Wu; Rajeev Hotchandani; Jason Shaoyun Xiang; Xuemei Du; Derek Cecil Cole; Steve Tam

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Jeremy I. Levin

Pennsylvania State University

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Jay Donald Albright

American Cyanamid

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Arie Zask

Columbia University

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Marvin F. Reich

American Cyanamid

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Jianchang Li

Pfizer

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Steve Tam

Pfizer

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Thomas S. Rush

Princeton University

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Wei Li

Pfizer

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Yansong Gu

American Cyanamid

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Yonghan Hu

Pfizer

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