Xueying Wang

Associations of gestational and early life exposures to ambient air pollution with childhood respiratory diseases in Shanghai, China: A retrospective cohort study

BACKGROUND Associations of ambient air pollutants with respiratory health are inconsistent. OBJECTIVES We analyzed the associations of gestational and early life exposures to air pollutants with doctor-diagnosed asthma, allergic rhinitis, and pneumonia in children. METHODS We selected 3358 preschool children who did not alter residences after birth from a cross-sectional study in 2011-2012 in Shanghai, China. Parents reported childrens respiratory health history, home environment, and family lifestyle behaviors. We collected daily concentrations of sulphur dioxide (SO2), nitrogen dioxide (NO2), and particulate matter with an aerodynamic diameter ≤10μm (PM10) during the childs total lifetime (2006-2012) for each district where the children lived. We analyzed the associations using logistic regression models. RESULTS After adjusting for covariates and the other studied pollutants, we found that exposure to NO2 (increment of 20μg/m(3)) during the first year of life was significantly associated with asthma [odds ratio (OR)=1.77; 95% confidence interval (CI): 1.29-2.43] and allergic rhinitis (OR=1.67; 95% CI: 1.07-2.61). Exposure to NO2 during gestation, the first two and three years, and over total lifetimewas all consistently associated with increased odds of allergic rhinitis. Quartiles of NO2 concentration during different exposure periods showed a slight dose-response relationship with the studied diseases. These diseases had significant associations with pollutant mixtures that included NO2, but had no significant association with exposures to SO2 and PM10 individually or in mixtures. CONCLUSIONS Gestational and early life exposures to ambient NO2 are risk factors for childhood respiratory diseases.

Associations of gestational and early life exposures to ambient air pollution with childhood atopic eczema in Shanghai, China

Whether ambient air pollution is associated with childhood atopic eczema is controversial. In this paper, we selected 3358 preschool children who had not altered residences since pregnancy from a cross-sectional study during 2011-2012 in Shanghai, China, and obtained parent-reported data regarding childhood atopic eczema using an improved ISAAC questionnaire. We recorded daily concentrations of SO2, NO2, and PM10 throughout the childs lifetime (2006-2012), and calculated period-averaged concentrations for each district where the child lived to represent the childs exposure levels of these pollutants during different periods. In the multiple logistic regression analyses adjusted for potential confounders as well as for the other pollutants in the same periods, childhood atopic eczema was significantly associated with increments of NO2 in the approximate interquartile range (20μg/m3) during gestational period (adjusted OR, 95% CI for eczema lifetime-ever: 1.80, 1.29-2.49; for eczema in the year prior to the survey: 2.32, 1.57-3.43) and during the first year of life (2.00, 1.40-2.84; 2.16, 1.43-3.28). Exposure to elevated NO2 in the first two years, three years and total lifetime, as well as exposure to mixtures containing NO2 in each of these periods, were consistently associated with increased likelihood of childhood eczema. The highest odds ratios were found between exposure to a mixture of SO2 and NO2 during total lifetime (increment: 35μg/m3) and childhood eczema (adjusted OR, 95% CI: 2.80, 1.75-4.48; 3.50, 1.98-6.19). No significant associations were found between childhood eczema and ambient SO2 and PM10 individually or in mixtures. This study indicates that gestational and lifetime exposures to ambient NO2 are risk factors for atopic eczema in childhood. Exposure to ambient SO2 and PM10 may enhance the effect of NO2 exposure on childhood eczema.

Breastfeeding and timing of first dietary introduction in relation to childhood asthma, allergies, and airway diseases: A cross-sectional study

ABSTRACT Objectives: We investigated associations of breastfeeding (BF) durations and patterns and of timing of other dietary introductions with prevalence of asthma, wheeze, hay fever, rhinitis, pneumonia, and eczema among preschool children. Methods: During April 2011-April 2012, we conducted a cross-sectional study in 72 kindergartens from five districts of Shanghai, China and obtained 13,335 questionnaires of children 4–6-years-old. We used multiple logistic regression models to evaluate the target associations. Results: Compared to children who were never BF, children who were exclusively breastfed 3–6 months had the lowest risk of asthma (adjusted odds ratio and 95% confidence interval: 0.81, 0.72–0.91) and wheeze (0.93, 0.87–0.99); and exclusive BF >6 months was significantly associated with a reduced risk of hay fever (0.93, 0.89–0.97), rhinitis (0.97, 0.94–0.99), pneumonia (0.97, 0.94–0.99), and eczema (0.96, 0.93–0.99). No significant associations were found between time when fruits or vegetables were introduced and the studied diseases. Associations were independent of the childs sex and parents ownership of the current residence. Longer duration BF was only significantly protective when there was no family history of atopy. Conclusions: This study suggests that heredity, but not sex and socioeconomic status, may negatively impact the effect of BF on childhood airway and allergic diseases. Our findings support Chinas national recommendation that mothers provide exclusive BF for the first four months, and continue partial BF for more than 6 months.

Household environmental exposures during gestation and birth outcomes: A cross-sectional study in Shanghai, China

Several studies have reported that certain aspects of the household environments are associated with adverse birth outcomes, but associations have been inconsistent. Few of these studies have been conducted in China. During 2011-2012, we conducted a retrospective cross-sectional study and collected 13,335 parents-reported questionnaires for 4-6-year-olds children in Shanghai, China. We investigated associations of household environmental factors (environmental tobacco smoke (ETS), cooking fuel, dampness, pet-keeping, and home renovation) during gestation with preterm birth (PTB, gestational age<37weeks), low birth weight (LBW, birth weight<2500g), term low birth weight (T-LBW, LBW when the gestational age was ≥37weeks), and small for gestational age (SGA, birth weight<10th percentile of birth weight for gestational age). A total of 4.1% children were premature; 2.9% had LBW and 1.6% had T-LBW; 8.1% were SGA. In the multiple logistic regression analyses, home renovation during gestation was associated with PTB (adjusted odds ratio (OR), 95% confidence intervals (CI): 1.68, 1.11-2.54) and LBW (1.64, 0.99-2.72). Paternal smoking was associated with PTB (1.18, 0.98-1.43). No significant associations were found for SGA. Neither household dampness nor cooking fuel were significantly associated with birth outcomes. For boys, paternal smoking was associated with PTB (1.31, 1.02-1.69); home renovation during gestation was associated with PTB (2.14, 1.27-3.61) and LBW (2.19, 1.09-4.43). Among children whose mothers were ≥34-year-olds during gestation, paternal smoking (1.73, 1.04-2.76) and home renovation during gestation (1.80, 1.18-2.76) was associated with PTB. Our findings demonstrate that home renovation and ETS during gestation may be risk factors for adverse birth outcomes. Associations of these factors with adverse birth outcomes appear to be stronger in boys and among mothers older than 34years during gestation. Home renovation and ETS exposure should be avoided during gestation, especially for pregnancies with male fetuses and older pregnant women.

Associations of urinary phthalate metabolites with residential characteristics, lifestyles, and dietary habits among young children in Shanghai, China

Exposure to household phthalates has been reported to have adverse effects on childrens health. In this paper, we used phthalate metabolites in the first morning urine as indicators of household phthalate exposures and examined their associations with residential characteristics, lifestyles and dietary habits among young children. During 2013-2014, we collected morning urines from children aged 5-10years in Shanghai, China and obtained the related information about analyzed factors in this study by questionnaires. Urinary phthalate metabolites were analyzed by isotope dilution-high performance liquid chromatography (HPLC)-heated electrospray ionization source (HESI) coupled with a triple quadrupole mass spectrometry. ANOVA, the Mann-Whitney or Kruskai-Wallis rank tests, and multivariate linear regression analyses were used to examine the target associations. Ten metabolites of seven phthalates in 434 urine samples were analyzed. The detection rates of eight metabolites (MiBP, MnBP, MEHP, MECPP, MEHHP, MEOHP, MEP, and MMP) were >90%, except for MBzP (51.2%), and MCHP with <10.0% of detection rate was not included in analyses. By multivariate linear regression analyses, factors significantly associated with higher concentrations of metabolites included non-usage household air cleaners (MEP and MEHP), changing the childs pillowcase less than one time a week (DEHP metabolites), dusting furniture in the childs bedroom less than three times a week (MMP and MnBP), using more plastic toys (DEHP metabolites and MEP), often having soft drinks (DEHP metabolites) and candies (MiBP). Our results indicated that phthalate exposures were common among Shanghai children and residential characteristics had less significant associations with urinary phthalate metabolites compared with lifestyles and dietary habits. Using less plastic toys, having less candies and soft drinks, using household air cleaner, as well as frequently changing the childs pillowcase and dusting furniture in the childs bedroom could reduce phthalate exposures among children.

Multimorbidities of asthma, allergies, and airway illnesses in childhood: Chance or not chance?

ABSTRACT Objectives: We investigated patterns of multimorbidities among asthma, allergies, and respiratory illnesses in preschool children. We investigated multimorbidities of lifetime asthma, allergic rhinitis, eczema, food allergy, pneumonia, and ear infections; and multimorbidities of current (in the last year before the survey) wheeze, dry cough, rhinitis, eczema, and common cold during childhood. We further analyzed whether prevalences of these multimorbidities were due to chance. Methods: A cross-sectional study was conducted in 72 kindergartens of Shanghai, China. Parents of preschool children were surveyed with a modified ISAAC questionnaire. Observed prevalences (OPs), expected prevalences (EPs), absolute excess comorbidities (AECs), and relative excess comorbidities (RECs) of various combinations of illnesses were calculated to indicate whether the combined illnesses were related. Results: We analyzed questionnaires for children aged 4–6 years, whose 13,335 questionnaires were the majority of the total 15,266 returned questionnaires (response rate: 85.3%). The studied illnesses were common. For children who had more than three lifetime or current illnesses, OPs tended to be higher than EPs. Most OPs and EPs were higher in boys than in girls, and were higher in children with a family history of atopy (FHA) than in children without FHA. AECs and RECs between boys and girls as well as between children with and without FHA were substantially different. Conclusions: Our findings suggest that multimorbidities among childhood asthma, allergies, and respiratory illnesses are likely not random, but rather share etiology. Specific patterns of childhood asthma multimorbidities perhaps differ between boys and girls and between children with and without FHA.

Urinary phthalate metabolites in relation to childhood asthmatic and allergic symptoms in Shanghai

BACKGROUND Few studies can be found on phthalate exposure in relation to childhood asthma and allergic symptoms from Mainland China, where a persistent increase in prevalence of childhood asthma and allergic disease has been observed. OBJECTIVES This study aimed to assess the exposure levels to phthalates and its relationship with asthmatic and allergic symptoms among children in Shanghai, which has the highest prevalence of childhood asthma in Mainland China. METHODS A follow-up study (2013-2014) of 434 children aged 5-10 years was conducted, based on the China, Children, Homes, Health (CCHH) study (2011-2012) in Shanghai, China. Information on asthmatic and allergic symptoms (wheeze, rhinitis, and eczema) were collected using validated questionnaires. Ten phthalate metabolites in morning urine samples were analyzed by high-performance liquid chromatography with triple quadrupole tandem mass spectrometry (HPLC-MS/MS). Multivariable logistic regression was used to estimate the associations between symptoms and urinary phthalate metabolites controlling for demographics, family history of allergic diseases and other covariates. RESULTS Nine out of 10 phthalate metabolites were detected in all subjects (average detection rate of 93.2%). By multivariable logistic regression analyses, the 4th quartile of Mono‑n‑butyl phthalate (MnBP) (reference: 1st quartile) had adjusted prevalence odds ratios (aPORS) and 95% confidence intervals (95%CIs) of 2.27(1.06-4.88), 2.14(1.02-4.46) and 2.98(1.19-7.50) for wheeze, rhinitis and eczema, respectively, while those of Mono‑isobutyl phthalate (MiBP) were 2.23(1.08-4.62) and 2.96(1.02-8.60) for rhinitis and eczema, respectively. The highest quartile of mono‑2‑ethyl‑5‑hydroxyhexyl phthalate(MEHHP) and mono‑2‑ethyl‑5‑oxohexyl phthalate(MEOHP) had aPORS and 95%CIs of 3.10(1.10-8.74) and 2.63(1.02-6.80) for eczema, respectively. By summing up the 4 low molecular weight metabolites (∑4LMWP) and all 9 metabolites (∑9Total), the highest quartiles of ∑4LMWP and∑9Total were significantly associated with all symptoms. In most of the above associations, a significantly increasing trend from the 1st to the 4th quartile was observed. Subjects with 2 or 3 concomitant symptoms (reference: no symptoms) had significant positive associations with a higher level (the 4th quartile) of phthalate metabolites. CONCLUSIONS Low MW metabolites such as MnBP and MiBP, high MW DEHP and the total amount of phthalate metabolites might have adverse health effects on asthma and allergic symptoms in Chinese children.