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Featured researches published by Xuli Wu.


Regulatory Toxicology and Pharmacology | 2009

Comments on serious anaphylaxis caused by nine Chinese herbal injections used to treat common colds and upper respiratory tract infections.

Kunmei Ji; Jiajie Chen; Meng Li; Zhigang Liu; Lixin Xia; Chunbo Wang; Zhengke Zhan; Xuli Wu

Abstract Reports describing severe allergic shock and fatality following treatment of a common cold or upper respiratory tract infection (URTI) with a Chinese herbal injection were collected. Our analysis of the risks associated with this treatment suggested that the potential risk of serious, or even lethal, anaphylaxis should preclude its use in treating common colds and URTIs. In light of our findings herein, we propose the following five suggestions for improving the clinical safety of delivering Chinese herbal injections as medical treatments. First, Chinese herbal injections should not be delivered in the clinic to treat patients in accordance with Bian zheng lun zhi (broad-spectrum application based on holistic Traditional Chinese Medicine (TCM) theory and methodology), but rather they should be administered to target specific indicated disease processes. Second, Chinese herbal injection indications should be based on the results of double-blind randomized controlled clinical trials. Third, Chinese herbal injections should be used only in cases involving severe disease or to rescue patients in critical condition; they should not be used to treat mild, relatively innocuous diseases, such as common colds and upper respiratory tract infections, given the risk of doing harm. Fourth, Chinese herbal injection formulas should include materials from only a single or a small number of plant sources in known quantities. Fifth, more studies examining the toxicology and allergenic potential of Chinese herbal injections are needed.


Trends in Food Science and Technology | 2009

Anaphylactic shock and lethal anaphylaxis caused by food consumption in China

Kunmei Ji; Jiajie Chen; Meng Li; Zhigang Liu; Chunbo Wang; Zhengke Zhan; Xuli Wu; Qingyou Xia

A review of case reports of anaphylactic shock and lethal anaphylaxis caused by food consumption occurring in China was conducted. Case reports published in Chinese medical journals from 1980 to 2007 were considered in the review. According to these reports, the most common allergenic offenders were pineapple, soft-shelled turtle and crab.


International Journal of Environmental Research and Public Health | 2016

Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China.

Kaiping Gao; Jinjin Wang; Linlin Li; Yujia Zhai; Yongcheng Ren; Haifei You; Bingyuan Wang; Xuli Wu; Jianna Li; Zichen Liu; Xiong Li; Yaxin Huang; Xinping Luo; Dongsheng Hu; Kinji Ohno; Chongjian Wang

Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963. The association of genetic variants in these four genes with T2DM was analyzed using multivariate logistic regression. Genotypes and allele distributions of KCNQ1 rs151290 were significantly different between the cases and controls (p < 0.05). The AC and CC genotypes and the combined AC + CC genotype of rs151290 in KCNQ1 were associated with increases risk of T2DM before (OR = 1.482, 95% CI = 1.062–2.069; p = 0.021; OR = 1.544, 95% CI = 1.097–2.172, p = 0.013; and OR = 1.509, 95% CI = 1.097–2.077, p = 0.011, respectively) and after (OR = 1.539, 95% CI = 1.015–2.332, p = 0.042; OR = 1.641, 95% CI = 1.070–2.516, p = 0.023; and OR = 1.582, 95% CI = 1.061–2.358, p = 0.024; respectively) adjustment for sex, age, anthropometric measurements, biochemical indexes, smoking and alcohol consumption. Consistent with results of genotype analysis, the C allele of rs151290 in KCNQ1 was also associated with increased risk of T2DM (OR = 1.166, 95% CI = 1.004–1.355, p = 0.045). No associations between genetic variants of KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected. The AC and CC genotypes and the C allele of rs151290 in KCNQ1 may be risk factors for T2DM in Han Chinese in Henan province.


Journal of Agricultural and Food Chemistry | 2018

Effect of Covalent Interaction with Chlorogenic Acid on the Allergenic Capacity of Ovalbumin

Yuqin Lu; Shuiming Li; Haoxie Xu; Tingting Zhang; Xiao Lin; Xuli Wu

Ovalbumin (OVA) is a major allergen in avian egg white. Here, we investigated the conjugation of OVA and chlorogenic acid (CHA) to reduce the allergenic capacity of OVA. OVA-CHA conjugate was characterized by SDS-PAGE, MALDI-TOF-MS, differential scanning calorimetry, and multispectroscopic methods. Sites of the OVA-CHA conjugate were identified by LC-MS/MS. CHA possibly conjugated with Lys20 and Lys17 in OVA, which resulted in the unfolding of OVA. ELISA and Western blot assay indicated that the OVA-CHA conjugate reduced the IgE binding capacity of OVA. The results also indicated that the ability of the OVA-CHA conjugate to activate histamine release was reduced. The decreased allergenic capacity of OVA was attributed to changes in the protein structure. Moreover, the CHA binding site in OVA might directly shield the linear IgE epitope, thereby reducing the IgE binding ability. Also, the OVA-CHA conjugate showed high antioxidant activity. OVA conjugated with CHA may be a promising method of OVA hyposensitization.


Food Chemistry | 2018

Reducing the allergenic capacity of β-lactoglobulin by covalent conjugation with dietary polyphenols

Xuli Wu; Yuqin Lu; Haoxie Xu; Dongxu Lin; Zhendan He; Haiqiang Wu; Lizhong Liu; Kaiping Gao; Zimei Wang; Xiao Lin; Jiaming Huang; Gongwei Wang; Chujie Zhu

To help produce hypoallergenic food, this study investigated reducing the allergenicity and improving the functional properties of bovine β-lactoglobulin (βLG) by covalent conjugation with (-)-epigallo-catechin 3-gallate (EGCG) and chlorogenic acid (CA). The covalent bond between the polyphenols and the amino acid side-chains in βLG was confirmed by MALDI-TOF-MS and SDS-PAGE. Structural analysis by fluorescence spectroscopy, circular dichroism (CD) and Fourier transform infrared (FTIR) indicated that the covalent conjugate of EGCG and CA led to the changed protein structure of βLG. Western blot analysis and enzyme-linked immunosorbent assay indicated that conjugation of βLG with these polyphenols was effective in reducing the IgE-binding capacity of βLG. The conjugates maintained the retinol-binding activity without denaturation the protein and enhanced the thermal stability with high antioxidant activity. The study provides an innovative approach to producing hypoallergenic food.


Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2011

Analysis of binding interaction between (-)-epigallocatechin (EGC) and β-lactoglobulin by multi-spectroscopic method.

Xuli Wu; Hui Wu; Meixia Liu; Zhigang Liu; Hong Xu; Furao Lai


Food Control | 2014

China food safety hits the "gutter"

Fangqi Lu; Xuli Wu


International Journal of Dairy Technology | 2013

Studies on the interaction of -epigallocatechin-3-gallate from green tea with bovine β-lactoglobulin by spectroscopic methods and docking

Xuli Wu; Raja Dey; Hui Wu; Zhigang Liu; Qingqing He; Xiaojuan Zeng


Trends in Food Science and Technology | 2010

Socio-technical innovations for total food chain safety during the 2008 Beijing Olympics and Paralympics and beyond

Xuli Wu; Hui Wu; Lixin Xia; Kunmei Ji; Zhigang Liu; Jiajie Chen; Dongsheng Hu; Chen Gao; Yan Wu


Lwt - Food Science and Technology | 2015

Effect of heat treatment on structure and immunogenicity of recombinant peanut protein Ara h 2.01

Liangliang Shen; Qian-Qian Zhu; Fengwen Huang; Hong Xu; Xuli Wu; Huafeng Xiao; Kai Zhou; Ming Ying; Shen-Li Tian; Gang Liu; Zhangli Hu; Zhigang Liu

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Hui Wu

South China University of Technology

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