Xunhua Yuan

A randomised trial comparing a short and a standard-length metaphyseal engaging cementless femoral stem using radiostereometric analysis

This was a randomised controlled trial studying the safety of a new short metaphyseal fixation (SMF) stem. We hypothesised that it would have similar early clinical results and micromovement to those of a standard-length tapered Synergy metaphyseal fixation stem. Using radiostereometric analysis (RSA) we compared the two stems in 43 patients. A short metaphyseal fixation stem was used in 22 patients and a Synergy stem in 21 patients. No difference was found in the clinical outcomes pre- or post-operatively between groups. RSA showed no significant differences two years post-operatively in mean micromovement between the two stems (except for varus/valgus tilt at p = 0.05) (subsidence 0.94 mm (SD 1.71) vs 0.32 mm (SD 0.45), p = 0.66; rotation 0.96° (SD 1.49) vs 1.41° (SD 2.95), p = 0.88; and total migration 1.09 mm (SD 1.74) vs 0.73 mm (SD 0.72), p = 0.51). A few stems (four SMF and three Synergy) had initial migration > 1.0 mm but stabilised by three to six months, with the exception of one SMF stem which required revision three years post-operatively. For most stems, total micromovement was very low at two years (subsidence < 0.5 mm, rotation < 1.0°, total migration < 0.5 mm), which was consistent with osseous ingrowth. The small sample makes it difficult to confirm the universal applicability of or elucidate the potential contraindications to the use of this particular new design of stem.

Randomised controlled trial comparing early migration of two collarless polished cemented stems using radiostereometric analysis

This was a safety study where the hypothesis was that the newer-design CPCS femoral stem would demonstrate similar early clinical results and micromovement to the well-established Exeter stem. Both are collarless, tapered, polished cemented stems, the only difference being a slight lateral to medial taper with the CPCS stem. A total of 34 patients were enrolled in a single-blinded randomised controlled trial in which 17 patients received a dedicated radiostereometric CPCS stem and 17 a radiostereometric Exeter stem. No difference was found in any of the outcome measures pre-operatively or post-operatively between groups. At two years, the mean subsidence for the CPCS stem was nearly half that seen for the Exeter stem (0.77 mm (-0.943 to 1.77) and 1.25 mm (0.719 to 1.625), respectively; p = 0.032). In contrast, the mean internal rotation of the CPCS stem was approximately twice that of the Exeter (1.61 degrees (-1.07 degrees to 4.33 degrees ) and 0.59 degrees (0.97 degrees to 1.64 degrees ), respectively; p = 0.048). Other migration patterns were not significantly different between the stems. The subtle differences in designs may explain the different patterns of migration. Comparable migration with the Exeter stem suggests that the CPCS design will perform well in the long term.

A Randomized Trial Comparing Acetabular Component Fixation of Two Porous Ingrowth Surfaces Using RSA

Several new porous ingrowth surfaces for acetabular component fixation have recently been developed. The purpose of this study was to compare the in vivo fixation achieved by two different porosity ingrowth surfaces using radiostereometric analysis (RSA). Sixty-two patients undergoing primary total hip arthroplasty (THA) were randomized to receive a cementless acetabular component with either a 61% high porosity asymmetric titanium porous surface (StikTite, Smith and Nephew, TN, USA) or a 45% low porosity sintered bead porous surface (Roughcoat, Smith and Nephew, TN, USA). RSA and clinical follow-up examinations were done post-operatively, 6-weeks, 3-months, 6-months, 1-year and 2-years. Both the high porosity StikTite and lower porosity Roughcoat surfaces provided excellent biologic fixation.

Radiostereometric analysis using clinical radiographic views: Validation measuring total hip replacement wear.

Radiostereometric analysis (RSA) is a stereo X‐ray technique used in clinical research studies to evaluate micro‐motion and wear of orthopaedic implants within bone. While highly accurate and precise, its adoption has been limited due to technical requirements such as the need for implanted marker beads and radiograph view angles determined by a calibration cage. We propose a new technique that separates the calibration procedure from the patient examination, enabling clinical radiograph views to be used for RSA measurements. The concept of a reference plate was adapted to establish the link between calibration procedure and patient examination procedure for cassette radiography, which may not be necessary for digital radiography. A hip wear phantom was used to validate this technique by comparing the error and repeatability of the novel procedure with that of conventional RSA. Femoral head penetration was measured versus the acetabular cup (head/cup) and marker beads in the acetabular liner (head/liner). Conventional RSA had lower inferior–superior average error (pu2009=u20090.03 for head/cup) while the modified RSA had lower anterior–posterior average error (pu2009=u20090.01). Average error was greater but not significantly so for the medial–lateral (pu2009=u20090.06) and 3D (pu2009=u20090.97) measurements. The head/liner method had lower average errors (pu2009<u20090.0001) for both procedures, but did not affect repeatability, which was similar between techniques. The novel procedures average error and repeatability was therefore, similar to conventional RSA. This new technique could be applied to any joint with two clinical radiograph view angles pending further validation in subjects.

Effect of Acetabular Position on Polyethylene Liner Wear Measured Using Simultaneous Biplanar Acquisition

BACKGROUNDnStudies that have previously examined the relationship between acetabular component inclination angle and polyethylene wear have shown increased wear of conventional polyethylene with high inclination angles. To date, there are no long-term inxa0vivo studies examining the correlation between cup position and polyethylene wear with highly crosslinked polyethylene.nnnMETHODSnAn institutional arthroplasty database was used to identify patients who had metal-on-highly crosslinked polyethylene primary total hip arthroplasty using the same component design with a minimum follow-up of 10 years. A modified radiostereometric analysis examination setup was utilized, recreating standard anteroposterior and cross-table lateral examinations in a single stereo radiostereometric analysis acquisition. The same radiographs were used to measure inclination angle and anteversion.nnnRESULTSnA total of 43 hips were included for analysis in this study. Average follow-up was 12.3 ± 1.2 years. The average linear wear rate was calculated to be 0.066 ± 0.066 mm/y. Inclination angle was not correlated with polyethylene wear rate (Pxa0= .82). Anteversion was also not correlated with polyethylene wear rate (Pxa0= .11).nnnCONCLUSIONnAt long-term follow-up of >10 years, highly crosslinked polyethylene has a very low wear rate. This excellent tribology is independent of acetabular position. The low wear rate highlights the excellent results of metal on highly crosslinked polyethylene, and supports its use in total hip arthroplasty.

Radiostereometric analysis of early anatomical changes following medial opening wedge high tibial osteotomy

BACKGROUNDnThe objective of this study was to use radiostereometric analysis (RSA) to evaluate the anatomical changes that occur in the tibia immediately after surgical correction with medial opening wedge high tibial osteotomy (HTO), and the changes that occur over the course of the first twelveweeks of osseous union.nnnMETHODSnPatients included nine males and one female, with a mean age of 49.0 ± 5.5 years and mean BMI of 28.4 ± 3.8 kg/m(2). The patients underwent HTO using a non-locking plate. RSA marker beads were inserted in the tibia, femur, and patella. RSA exams were first obtained intra-operatively prior to the osteotomy, and subsequently at one, two, four, six, and twelveweeks postoperatively.nnnRESULTSnPatients were corrected from a mean alignment preoperatively of 8.6 ± 2.5° to 0.3 ± 1.9° postoperatively, with a mean osteotomy of 12.5 ± 3.6mm. Immediate tibia changes surrounding the osteotomy site included 9.2 ± 2.4° of valgus rotation and 6.2 ± 2.0mm of distal translation. Secondary motions included 2.5 ± 2.4° of internal rotation of the distal tibia, 1.8 ± 1.4mm of posterior movement of the femur, and 8.5 ± 3.4mm of patella baja. Micromotion between the proximal and distal tibial segments decreased over time.nnnCONCLUSIONnThe results suggest that subtle changes to the anatomy occur, beyond what is intended with the procedure, but partial corrections of these phenomena occurred over the twelveweeks. Micromotion surrounding the osteotomy site decreased with osseous union.

Error analysis of marker-based object localization using a single-plane XRII

The role of imaging and image guidance is increasing in surgery and therapy, including treatment planning and follow-up. Fluoroscopy is used for two-dimensional (2D) guidance or localization; however, many procedures would benefit from three-dimensional (3D) guidance or localization. Three-dimensional computed tomography (CT) using a C-arm mounted x-ray image intensifier (XRII) can provide high-quality 3D images; however, patient dose and the required acquisition time restrict the number of 3D images that can be obtained. C-arm based 3D CT is therefore limited in applications for x-ray based image guidance or dynamic evaluations. 2D-3D model-based registration, using a single-plane 2D digital radiographic system, does allow for rapid 3D localization. It is our goal to investigate-over a clinically practical range-the impact of x-ray exposure on the resulting range of 3D localization precision. In this paper it is assumed that the tracked instrument incorporates a rigidly attached 3D object with a known configuration of markers. A 2D image is obtained by a digital fluoroscopic x-ray system and corrected for XRII distortions (+/- 0.035 mm) and mechanical C-arm shift (+/- 0.080 mm). A least-square projection-Procrustes analysis is then used to calculate the 3D position using the measured 2D marker locations. The effect of x-ray exposure on the precision of 2D marker localization and on 3D object localization was investigated using numerical simulations and x-ray experiments. The results show a nearly linear relationship between 2D marker localization precision and the 3D localization precision. However, a significant amplification of error, nonuniformly distributed among the three major axes, occurs, and that is demonstrated. To obtain a 3D localization error of less than +/- 1.0 mm for an object with 20 mm marker spacing, the 2D localization precision must be better than +/- 0.07 mm. This requirement was met for all investigated nominal x-ray exposures at 28 cm FOV, and for all but the lowest two at 40 cm FOV. However, even for those two nominal exposures, the expected 3D localization error is less than +/- 1.2 mm. The tracking precision was +/- 0.65 mm for the out-of-plane translations, +/- 0.05 mm for in-plane translations, and +/- 0.05 degrees for the rotations. The root mean square (RMS) difference between the true and projection-Procrustes calculated location was 1.07 mm. It is believed these results show the potential of this technique for dynamic evaluations or real-time image guidance using a single x-ray source and XRII detector.

Varus tibial alignment is associated with greater tibial baseplate migration at 10 years following total knee arthroplasty

PurposeTo examine implant migration and articular behavior of primary total knee arthroplasty (TKA) at 10xa0years after index surgery and correlate to implant alignment.MethodsThirty-five patients underwent a cemented posterior stabilized total knee arthroplasty with a surgical objective of neutral alignment and were enrolled in a long-term radiostereometric analysis (RSA) study. At 10xa0years after surgery, patients were analyzed for implant migration using RSA as well as radiographic assessment of articular behavior at four positions of knee flexion. Implant position and alignment was measured on full-length radiographs. Patient demographics and reported outcomes were also collected.ResultsNo difference between patient demographics or patient-reported outcomes were found. When categorized into neutral and varus groupings, no difference in migration was present. If alignment was considered as a continuous variable, there was no correlation between overall leg alignment and migration, however, migration increased with an increasing varus tibial alignment. Although contact location did not differ between neutral and varus groups through a range of motion, condylar liftoff was much more common in the varus group, of which all were lateral liftoff.ConclusionsIncreased tibial varus results in increased implant migration. Overall varus limb alignment is correlated with isolated lateral compartment liftoff, and liftoff occurs more commonly than in neutral aligned knees. The increased migration and liftoff raise concerns about the longevity of malaligned total knee replacements. If a goal of overall varus limb alignment is desired for TKA, the tibia should remain neutral.Level of evidenceLevel III.

A marker-based technique for visualizing radiolucent implant components in radiographic imaging†

Radiography is the predominant imaging modality used for the in‐vivo analysis of orthopaedic implants. A major disadvantage of radiography is that the articulating joint components that are composed of radiolucent polyethylene cannot be directly visualized. Current strategies attempt to circumvent this limitation by estimating component positions and simplifying the joint system, however, these approaches lead to a number of associated errors. Thus, this study provides a method to enable the visualization of the polyethylene component of total knee replacements in radiographic images. This was achieved through the repeatable insertion of markers and accompanying registration process, which were evaluated in this study for reproducibility and accuracy. An insertion guide was developed to insert tantalum beads into polyethylene tibial surface liners. The bead‐inserted liners were micro‐CT scanned to obtain 3D surface geometries. An in‐vivo mimicking phantom RSA experiment was then used to test the 3D to 2D registration process. The guide positioned the beads consistently to ±0.21u2009mm. The 3D to 2D registration demonstrated a repeatability of −0.014u2009±u20090.008u2009mm. Registration of different bead‐inserted tibial liners to the phantom revealed an average error of 0.026u2009±u20090.047u2009mm for this visualization method. This visualization approach provides greatly improved registration and inter‐component measurements than current alternative strategies. This process is suitable for a number of other joints and would greatly benefit procedures that analyze component interactions and implant performance over time.

Quantification of in vivo implant wear in total knee replacement from dynamic single plane radiography

An in vivo method to measure wear in total knee replacements was developed using dynamic single-plane fluoroscopy. A dynamic, anthropomorphic total knee replacement phantom with interchangeable, custom-fabricated components of known wear volume was created, and dynamic imaging was performed. For each frame of the fluoroscopy data, the relative location of the femoral and tibial components were determined, and the apparent intersection of the femoral component with the tibial insert was used to calculate wear volume, wear depth, and frequency of intersection. No difference was found between the measured and true wear volumes. The precision of the measurements was ±39.7 mm(3) for volume and ±0.126 mm for wear depth. The results suggest the system is capable of tracking wear volume changes across multiple time points in patients. As a dynamic technique, this method can provide both kinematic and wear measurements that may be useful for evaluating new implant designs for total knee replacements.