Y.F. Masters

Mechanism of Stress Ulcer: IV. Influence of fasting on the tolerance of gastric mucosal energy metabolism to ischemia and on the incidence of stress ulceration

We have proposed that stress ulceration complicating hemorrhagic shock results from a gastric mucosal energy deficit due to shockinduced mucosal ischemia. If this hypothesis were correct, any agency which interferes with the ability of the mucosa to meet its energy demands during shock should also abet the process of stress ulceration. We have studied gastric mucosal energy metabolism and vulnerability to stress ulceration in fasted and nonfasted rabbits. The data presented in this report indicate that the energy deficit appearing in the gastric mucosa of fasted rabbits during hemorrhagic shock is significantly greater than that measured in nonfasted animals subjected to the same degree of shock. When we studied the incidence of acute gastric mucosal injury in fasted and nonfasted rabbits subjected to the same degree of hemorrhagic shock, we found the former to be more liable to stress ulceration.

Content of Gastric Inhibitory Substance in Saliva of Patients with Various Gastric Disorders

Summary Samples of saliva were collected from normal individuals and from patients with duodenal ulcer, gastric ulcer, and gastric cancer. The concentration of gastric inhibitory substance in saliva pooled from these various groups of subjects was measured by bioassay on gastric secretion of rats after ligation of the pylorus. Saliva from patients with gastric ulcer and gastric cancer had a significantly greater concentration of inhibitory substance than saliva from patients with duodenal ulcer.

Enhancement by Parathyroidectomy of Glycoprotein Mobilizing Property of Parathyroid Extract.

Summary The effects of PTE on serum Ca++ and serum total glycoprotein levels as well as on serum sialic acid levels in normal and parathyroidectomized rats were studied. Alterations in serum glycoprotein and serum protein fractions under these conditions were measured also. The degree of metastatic calcification and of tissue concentrations of glycoproteins was measured by special stains of kidney sections and by measurement of sialic acid concentration in gastric mucosa. The rise in serum Ca++ and glycoprotein levels normally occurring in rats given PTE was greatly enhanced by parathyroidectomy. PTE-induced alterations in serum protein and glycoprotein fractions were greater in parathyroidectomized rats. The latter also had more rapid onset of renal calcification and greater tissue deposition of glycoproteins.