Y.S. Wang

Systematic Calculations of Energy Levels and Transition Rates of Be-like Ions with Z=10–30 Using a Combined Configuration Interaction and Many-body Perturbation Theory Approach

We report calculations of energy levels and radiative rates for transitions among the lowest 116 fine-structure levels arising from the configurations in Be-like ions with Z = 10–30. The wavelengths, oscillator strengths, line strengths, and radiative rates for all possible electric dipole, magnetic dipole, electric quadrupole, and magnetic quadrupole transitions among the 116 levels have been calculated using the combined configuration interaction and many-body perturbation method. The accuracy of the results is determined through extensive comparisons with existing laboratory measurements and theoretical results. The present complete set of results should be of great help in line identification and the interpretation of spectra, as well as in the modeling and diagnostics of astrophysical and fusion plasmas.

Relativistic many-body calculations on wavelengths and transition probabilities for forbidden transitions within the

Wavelengths and transition probabilities have been computed for forbidden lines within the 3dk(k = 1-9) ground configurations in ions of hafnium, tantalum, tungsten and gold, employing the second-order relativistic many-body perturbation theory (RMBPT). For comparison, the relativistic configuration-interaction (RCI) calculations have also been performed. Comparing to the previously published theoretical wavelengths and the present RCI ones, the present RMBPT results are in much better agreement with the experimental values measured recently by using the electron beam ion trap facility, reproducing these observed wavelengths to within 0.2% for all transitions only with one exception. In addition, it removes dramatically the systematic underestimation/overestimation for shorter/longer wavelengths existing in the present RCI and other calculations.

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Hearing defects can significantly influence quality of life for those who experience them. At this time, 177 deafness genes have been cloned, including 134 non-syndromic hearing-loss genes. The methionine sulfoxide reductase B3 (Ahmed et al., 2011) gene (also called DFNB74) is one such newly discovered hearing-loss gene. Within this gene c.265 T>G and c.55 T>C mutations are associated with autosomal recessive hearing loss. However, the biological role and mechanism underlying how it contributes to deafness is unclear. Thus, to better understand this mutation, we designed splicing morpholinos for the purpose of down-regulating msrb3 in zebrafish. Morphants exhibited small, tiny, fused, or misplaced otoliths and abnormal numbers of otoliths. Down-regulation of msrb3 also caused shorter, thinner, and more crowded cilia. Furthermore, L1-8 neuromasts were reduced and disordered in the lateral line system; hair cells in each neuromast underwent apoptosis. Co-injection with human MSRB3 mRNA partially rescued auditory system defects, but mutant MSRB3 mRNA could not. Thus, msrb3 is instrumental for auditory system development in zebrafish and MSRB3-related deafness may be caused by promotion of hair cell apoptosis.

ground configurations in Co- through K-like ions of hafnium, tantalum, tungsten and gold

DNA methylation plays an important role for mammalian development. However, it is unclear whether the DNA methylation pattern is evolutionarily conserved. The Y chromosome serves as a powerful tool for the study of human evolution because it is transferred between males. In this study, based on deep-rooted pedigrees and the latest Y chromosome phylogenetic tree, we performed epigenetic pattern analysis of the Y chromosome from 72 donors. By comparing their respective DNA methylation level, we found that the DNA methylation pattern on the Y chromosome was stable among family members and haplogroups. Interestingly, two haplogroup-specific methylation sites were found, which were both genotype-dependent. Moreover, the African and Asian samples also had similar DNA methylation pattern with a remote divergence time. Our findings indicated that the DNA methylation pattern on the Y chromosome was conservative during human male history.

Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish.

Abstract In this work, some fitting formulas for the accurate and fast calculation of rate coefficient are given. Some fitting parameters of direct ionization cross sections and excitation autoionization cross section are also provided. The rate coefficients of some H-like, He-like and Li-like ions are calculated.

Epigenetic Pattern on the Human Y Chromosome Is Evolutionarily Conserved.

Hearing loss is one of the most prevalent human birth defects. Genetic factors contribute to the pathogenesis of deafness. It is estimated that one-third of deafness genes have already been identified. The current work is an attempt to find novel genes relevant to hearing loss using guilt-by-profiling and guilt-by-association bioinformatics analyses of approximately 80 known non-syndromic hereditary hearing loss (NSHL) genes. Among the 300 newly identified candidate deafness genes, slc26a2 were selected for functional studies in zebrafish. The slc26a2 gene was knocked down using an antisense morpholino (MO), and significant defects were observed in otolith patterns, semicircular canal morphology, and lateral neuromast distributions in morphants. Loss-of-function defects are caused primarily by apoptosis, and morphants are insensitive to sound stimulation and imbalanced swimming behaviours. Morphant defects were found to be partially rescued by co-injection of human SLC26A2 mRNA. All the results suggest that bioinformatics is capable of predicting new deafness genes and this showed slc26a2 is to be a critical otic gene whose dysfunction may induce hearing impairment.

RATE COEFFICIENTS OF ELECTRON IMPACT IONIZATION FOR HIGHLY IONIZED IONS

Abstract A distorted-wave Born exchange (DWBE) approximation including relativistic correction is used to calculate the electron-impact ionization cross sections and rate coefficients for the highly charged ions Ar7+,…,Ar17+. The comparison of the calculated results with the experimental data and other theoretical calculations shows that the DWBE method is valid for these ions of argon. The calculated results for direct ionization cross sections and excitation autoionization were fitted by empirical formulas to meet the requirements of applications. A set of improved empirical formulas are used for the fast and accurate calculations of rate coefficients from the fit parameters of cross sections.

Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish

Abstract In this work, based on the calculation in detail, two new fitting formulae of total excitation and excitation autoionization cross-sections for Na-like ions (18⩽Z⩽39) are given. For discussing the variation of the total excitation autoionization cross-section, a systematic study of the dependence of the overall branching ratio on incident electron energy and nuclear charge is also carried out.