Yahui Fu

Overexpression of HMGB1 A-box reduced IL-1β-induced MMP expression and the production of inflammatory mediators in human chondrocytes

The pro-inflammatory cytokine interleukin-1 beta (IL-1β) plays a crucial role in the pathogenesis of osteoarthritis (OA) by stimulating several mediators that contribute to cartilage degradation. The aim of this study was to investigate the effects and mechanism of high mobility group box 1 (HMGB1) inhibitors HMGB1 A-box on the expression of matrix metalloproteinase (MMP) and the production of inflammatory mediators in human osteoarthritis chondrocytes after activation by IL-1β. We found that the overexpression of HMGB1 A-box significantly decreased the IL-1β-stimulated the production of MMP-1, MMP-3 and MMP-9, and also reduced the elevated levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) associated with the inhibition of prostaglandin E2 (PGE2) and nitric oxide (NO) production in IL-1β-stimulated chondrocytes. In addition, overexpression of the HMGB1 A-box significantly inhibited the up-regulation of ADAMTS-4, ADAMTS-5 and HMGB1 caused by IL-1β in chondrocytes. Moreover, the overexpression of HMGB1 A-box markedly suppressed the IL-1β-mediated activation of the Toll-like receptor 4 (TRL4)/NF-κB pathway. Our observations indicated that the HMGB1 A-box can play a protective role by suppressing the IL-1β-induced expression of MMPs and that the production of inflammatory mediators in chondrocytes was associated with suppression of the HMGB1/TLR4/NF-κB pathway. In conclusion, HMGB1 A-box relieves the development of OA that may be associated with regulating the HMGB1/TLR4/NF-κB pathway.

Erratum to “Lasso plate – An original implant for fixation of type I and II Regan-Morrey coronoid fractures” [Orthop. Traumatol. Surg. Res. 103 (2017) 447–51]

Please cite this article in press as: Wang P, et al. Erratum to “Lasso plate – An original implant for fixation of type I and II Regan-Morrey coronoid fractures” [Orthop. Traumatol. Surg. Res. 103 (2017) 447–51]. Orthop Traumatol Surg Res (2017), http://dx.doi.org/10.1016/j.otsr.2017.05.001 f the results section of the abstract and the text. Page 447 and page 449, the sentences should be “All patients were reexamined at a mean ollow-up of 22.1 months (range: 12–38 months). The mean fractures healing time was 13.6 weeks (range: 8–18 weeks)”. In the last line f Table 2, page 450, the MS of flex, pro, sup and FU should be 121.8, 75.8, 80.4 and 22.1 respectively. The authors apologize for these errors. These changes do not affect the key points and conclusions of the original paper.

The role of ultrasonography in examination of the stability of Tile-B2 pelvic fractures: 7 case reports and a literature review

Background: Determining whether a Tile-B2 pelvic fracture is stable is very challenging. We sought to identify the role of ultrasonography in determining the stability of Tile-B2 pelvic fractures. Methods: We collected the clinical data of patients with Tile-B2 pelvic fractures who presented at Xi’an Hong-Hui Hospital between June 1, 2016, and August 5, 2016. The treatment strategy of each patient was determined by a team of senior surgeons in the department. A single sinologist observed the movement of the fracture sites in patients during rest, under compression, and during separation to determine fracture stability. According to the pelvic fracture stability assessment, an appropriate treatment strategy was redetermined. Overall, 7 patients, including 5 women and 2 men, with Tile-B2 pelvic fractures were included in this case series. Results: During the initial examination, senior surgeons recommended that 2 patients should undergo internal fixation and 4 patients, conservative treatment; treatment was undecided for 1 patient. After ultrasonography examination, 4 patients underwent surgery via the Stoppa (n = 2) or ilioinguinal approach (n = 1) or cannulated screw fixation (n = 1). The rest of the patients (n = 3) received conventional treatment. Follow-up ranged from 6 to 10 months. Most of the patients showed excellent functions based on their last Majeed grading scores. There were no complications during the follow-up. Using ultrasonography examination, the preoperative treatment plan in 1 patient was changed, and the uncertain preoperative plan in 1 patient was identified. Conclusion: Preoperative assessment of stability using ultrasonography may assist surgeons in making appropriate treatment choices for patients with Tile-B2 pelvic fractures.