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Dive into the research topics where Yan-Wen Zhang is active.

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Featured researches published by Yan-Wen Zhang.


Fitoterapia | 2015

Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice.

Pi-Yong Hou; Chao Mi; Yi He; Jun Zhang; Shu-Qing Wang; Fei Yu; Samantha Anderson; Yan-Wen Zhang; Xiao-Hui Wu

Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be effective in hyperuricemic control. Allopurinol is a commonly used medication to treat hyperuricemia and its complications. In this study, we evaluated whether Pallidifloside D could enhance allopurinols effects by decreasing the serum uric acid level in a hyperuricemic mouse model induced by potassium oxonate. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level (both P<0.05), leading to the normalized serum and urine uric acid concentrations. Data on serum, urine creatinine and BUN supported these observations. Our results showed that the synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. Our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions.


Journal of Asian Natural Products Research | 2005

Terpene alkaloids from Tripterygium wilfordii

Xiaodong Wang; Wei Jia; Wenyuan Gao; Rong Zhang; Yan-Wen Zhang; Jun Zhang; Yoshihisa Takaishi; Hong-Quan Duan

Two new sesquiterpene alkaloids, 1β-hydroxy-2β,5α,11-triacetoxy-7β-nicotinoyl-8β-benzoyl-dihydroagarofuran (1), and 1β,5α,11-triacetoxy-7β-nicotinoyl-8β-benzoyl-dihydroagarofuran (2) were isolated from the xylem of Tripterygium wilfordii, together with six known compounds. Their structures were elucidated on the basis of spectroscopic studies.


Journal of Asian Natural Products Research | 2011

Acetylated anthraquinone glycosides from Cassia obtusifolia

Xiao-Hui Wu; Jin-Jin Cai; Jin-Lan Ruan; Jianshi Lou; Hong-Quan Duan; Jun Zhang; Chun-Ru Cheng; De-An Guo; Zhi-Yuan Wu; Yan-Wen Zhang

Three new acetylated anthraquinone glycosides (1–3) were isolated from the seed of Cassia obtusifolia, together with one parent anthraquinone glycoside (1a). Their structures were determined on the basis of spectroscopic methods and physicochemical properties as obtusifoline-2-O-β-d-2, 6-di-O-acetylglucopyranoside (1), obtusifoline-2-O-β-d-glucopyranoside (1a), obtusifoline-2-O-β-d-3, 6-di-O-acetylglucopyranoside (2), and obtusifoline-2-O-β-d-4, 6-di-O-acetylglucopyranoside (3).


Natural Product Research | 2010

A new labdanic norditerpene from Pinus sylvestris.

Jie Teng; Rong Zhang; Yan-Wen Zhang; Hong-Quan Duan; Yoshihisa Takaishi

A new labdanic norditerpene and six known labdanic diterpenes were isolated from the petroleum ether extract of the needles of Pinus sylvestris. By spectroscopic methods, the isolated compounds were determined as 15-norpinifolic acid (1), pinifolic acid (2), 4-eplimbricataloic acid (3), monomethyl pinifolate (4), 18α-acetoxylabd-8(17)-en-15-oic acid (5), 2-pentenoic acid (6) and 3β-hydroxy-8(17),E-13-labdadien-15-oic acid (7), respectively. Compound 1 showed significant anti-tumour activity.


Journal of Asian Natural Products Research | 2009

Six new cycloartane triterpene glycosides from Actaea asiatica

Yun-Shuang Fan; Zhi Yao; Yan-Wen Zhang; Hong-Quan Duan

Six new cycloartane triterpene glycosides, (3′,12β)-O-diacetyl-cimigenol-3-O-β-d-xylopyranoside (1), (4′,25)-O-diacetyl-cimigenol-3-O-β-d-xylopyranoside (2), 2′-O-acetyl-25-O-methyl-cimigenol-3-O-β-d-xylopyranoside (3), 2′-O-acetyl-25-O-ethyl-cimigenol-3-O-β-d-xylopyranoside (4), 3′-O-acetyl-cimicifugoside (5), and 4′-O-acetyl-23-epi-26-deoxycimifugoside (6), were isolated from the rhizomes of Actaea asiatica. Their structures were elucidated on the basis of chemical methods and spectroscopic analysis. Compounds 1, 2, 4–6 exhibited positive cytotoxic activities.


Fitoterapia | 2016

Hypouricemic effect of allopurinol are improved by Pallidifloside D based on the uric acid metabolism enzymes PRPS, HGPRT and PRPPAT

Hong-Gang Li; Pi-Yong Hou; Xi Zhang; Yi He; Jun Zhang; Shu-Qing Wang; Samantha Anderson; Yan-Wen Zhang; Xiao-Hui Wu

Allopurinol is a commonly used medication to treat hyperuricemia and its complications. Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to enhanced hypouricemic effect of allopurinol based on uric acid metabolism enzyme XOD. In this study, we evaluated whether Pallidifloside D (5mg/kg) enhanced hypouricemic effect of allopurinol (5mg/kg) related to others uric acid metabolism enzymes such as PRPS, HGPRT and PRPPAT. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly up-regulated HGPRT mRNA expression and down-regulated the mRNA expression of PRPS and PRPPAT in PC12 cells (all P<0.01). These results strongly suggest that hypouricemic effect of allopurinol are improved by Pallidifloside D via numerous mechanisms and our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions.


Fitoterapia | 2012

Three new acetylated benzyl-beta-resorcylate glycosides from Cassia obtusifolia.

Xiao-Hui Wu; Jin-Lan Ruan; V.C. Yang; Zhi-Yuan Wu; Jianshi Lou; Hong-Quan Duan; Jun Zhang; Yan-Wen Zhang; De-An Guo

Three new acetylated benzyl-beta-resorcylate glycosides (1-3) were isolated from seeds of Cassia obtusifolia. Their structures were determined on the basis of the spectroscopic methods and physicochemical properties as 2-benzyl-4,6-dihydroxy benzoic acid-6-O-[2,6-O-diacetyl]-D-glucopyranoside (1), 2-benzyl-4,6-dihydroxy benzoic acid-6-O-[3,6-O-diacetyl]-D-glucopyranoside (2) and 2-benzyl-4, 6-dihydroxy benzoic acid-6-O-[4,6-O-diacetyl]-D-glucopyranoside (3), respectively.


Xenobiotica | 2018

Intestinal absorption of pallidifloside D are limited by P-glycoprotein in mice

Ming-Yu Wang; Ming Yang; Pi-Yong Hou; Xiu-Bo Chen; Hong-Gang Li; Jiu-Xing Yan; Jun Zhang; Yan-Wen Zhang; Xiao-Hui Wu

Abstract 1. Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be very effective in hyperuricemic control. But it is poorly bioavailable after oral administration. Here, we determined the role of P-glycoprotein (P-gp) in the intestinal absorption of Pallidifloside D. 2. We found that Pallidifloside D significantly stimulated P-gp ATPase activity in vitro ATPase assay with a small EC50 value of 0.46 μM. 3. In the single-pass perfused mouse intestine model, the absorption of Pallidifloside D was not favored in the small intestine (duodenum, jejunum and ileum) with a P*w value of 0.35–0.78. By contrast, this compound was well-absorbed in the colon with a P*w value of 1.23. The P-gp inhibitors cyclosporine significantly enhanced Pallidifloside D absorption in all four intestinal segments (duodenum, jejunum, ileum and colon) and the fold change ranged from 5.5 to 15.3. Pharmacokinetic study revealed that cyclosporine increased the systemic exposure of Pallidifloside D by a 2.5-fold after oral administration. 4. These results suggest that P-gp-mediated efflux is a limiting factor for intestinal absorption of Pallidifloside D in mice.


Medicinal Chemistry | 2015

Polyphenols from the Rhizomes of Potentilla freyniana

Xiao-Hui Wu; Chao Mi; Yi He; Shu-Qing Wang; Jun Zhang; Yan-Wen Zhang

A new polyphenol, Potentillanin A (1), together with two known compounds (2–3), was isolated from the chloroform soluble fraction of Potentilla freyniana. The structure of Potentillanin A (1) was elucidated by spectroscopicmethods.


Journal of Ethnopharmacology | 2014

Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice.

Xiao-Hui Wu; Jinlan Ruan; Jun Zhang; Shu-Qing Wang; Yan-Wen Zhang

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Jun Zhang

Tianjin Medical University

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Hong-Quan Duan

Tianjin Medical University

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Shu-Qing Wang

Tianjin Medical University

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Pi-Yong Hou

Tianjin Medical University

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Yi He

Tianjin Medical University

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Chao Mi

Tianjin Medical University

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Hong-Gang Li

Tianjin Medical University

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