Yana Navmenova

Metabolic control and depression in type 1 diabetes mellitus

The most common mental disorder in patients with diabetes mellitus (DM) is depression (DS). Despite the large number of papers about DS in DM, its prevalence in type 1 DM (T1DM) remains unclear. Aim. The aim of this study was to investigate the prevalence of DS in T1DM and its possible association with metabolic control disorders. Materials and Methods. The study included 163 patients with T1DM. The patients were aged 18?65 years, and the mean duration of T1DM was 11.18 years (range 4.28?22.33 years). The control group included 75 apparently healthy individuals. The subjects underwent physical examination, and the standard self-report Hospital Anxiety and Depression Scale questionnaire was administered to evaluate the level of anxiety and DS. Psychological counselling was conducted to diagnose DS and its severity. The continuous glucose monitoring system (CGMS) was used to monitor interstitial fluid glucose levels. Statistical analysis was conducted using SPSS Statistics 17.0 and StatSoft Statistica 6.0. Results. The prevalence of DS among the patients with T1DM was much higher (approximately two-fold) than the prevalence among the healthy individuals. Female sex and age over 40 years were associated with the presence of DS. Conclusion. The development of DS in patients with T1DM is accompanied by poor glycaemic control and increased risk of hypoglycaemic episodes.

The results of evaluation of dynamics of levels of glycemia in diabetes mellitus type 1

The aim of the work was to assess the dynamics of rates of carbohydrate metabolism in diabetes mellitus type 1 (DMТ1) in young persons. Materials and methods. The study of daily dynamics of glucose was conducted by Continuous Glucose Monitoring System (CGMS) of MedtronikMINIMED Company, USA. Standard glucose profile (4-5 per day) was measured in capillary blood by glucometer «FinetestTM», Infopia Co., Ltd. For the analysis of continuous glycemic curve there was conducted the computation of risk index (RI) of hypoglycemia and hyperglycemia during the study period. There were examined 162 patients with DMТ1. First group with adequate control DMТ1, НbA1с ≤ 7,5% (n = 38), which is 23% and second group with inadequate control, НbA1с> 7,5% (n = 124), which is 77 % of the total number of examined persons. Clinical characteristics of the examined persons depending on hypoglycemic episodes manifestation Ме (25%;75%) 1st Group with НbА1с ≤ 7,5 % (n = 38) 2nd group with НbА1с > 7,5 % (n = 124) р Age , years 29,81 [25,84; 35,26] 28,73 [21,94; 36,04] 0,388 Duration of T1DM, years 7,71 [2,98; 13,53] 8,52 [3,89; 14,22] 0,289 Body mass index , kg/м2 23,64 [21,46; 26,00] 23,73 [21,96; 26,14] 0,541