Yancey David Ward

SOLID PHASE SYNTHESIS OF ARYL AMINES VIA PALLADIUM CATALYZED AMINATION OF RESIN-BOUND AROMATIC BROMIDES

Abstract Polymer-bound aromatic bromides were found to readily undergo Pd-catalyzed amination with a number of primary and secondary alkyl- and arylamines to give, after cleavage from the support, a variety of arylamine products.

Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement.

This paper details exploration of a class of triazole-based cathepsin S inhibitors originally reported by Ellman and co-workers. SAR studies involving modifications across the whole inhibitor provide a perspective on the strengths and weaknesses of this class of inhibitors. In addition, we put the unique characteristics of this class of compounds into perspective with other classes of cathepsin S inhibitors.