Yasuaki Muguruma

Masato Matsugi; Norio Fukuda; Yasuaki Muguruma; Taizo Yamaguchi; Jun-ichi Minamikawa; Sei Otsuka

Abstract An effective catalytic asymmetric oxidation of prochiral sulfide 1a to (S)-2a has been achieved by the use of chiral titanium–mandelic acid complex. The enantioselectivity was found to be not influenced by moisture, and moderate to high selectivity (76% ee) was obtained at room temperature (25°C). Thus a practical synthetic method for the platelet adhesion inhibitor, OPC-29030, was established utilising asymmetric oxidation of 1a.

Yasuhiro Torisawa; Kaoru Abe; Yasuaki Muguruma; Shigekazu Fujita; Hidenori Ogawa; Naoto Utsumi; Masahiro Miyake

Yoshihiko Okaichi; Nobuhito Tada; Daisuke Nomi; Nobuhisa Fujita; Koichi Tsuji; Taizo Yamaguchi; Yasuaki Muguruma; Hisayuki Tsujimori

Yasuhiro Torisawa; Kaoru Abe; Yasuaki Muguruma; Shigekazu Fujita; Naoto Utsumi; Hidenori Ogawa; Masahito Miyake; 将仁 三宅; 寧成 六車; 尚登 宇積; 英則 小川; 繁和 藤田; 薫 阿部; 保廣 鳥澤

保廣 鳥澤; Yasuhiro Torisawa; 阿部 薫; Kaoru Abe; 薫 阿部; 寧成 六車; Yasuaki Muguruma; 繁和 藤田; Shigekazu Fujita; 尚登 宇積; Naoto Utsumi; 英則 小川; Hidenori Ogawa; 将仁 三宅; Masahito Miyake

Yasuhiro Torisawa; 保廣 鳥澤; Kaoru Abe; 薫 阿部; Yasuaki Muguruma; 寧成 六車; Shigekazu Fujita; 繁和 藤田; Naoto Utsumi; 尚登 宇積; Hidenori Ogawa; 英則 小川; Masahito Miyake; 将仁 三宅

Yasuhiro Torisawa; Kaoru Abe; Yasuaki Muguruma; Shigekazu Fujita; Naoto Utsumi; Hidenori Ogawa; Masahito Miyake; 将仁 三宅; 寧成 六車; 尚登 宇積; 英則 小川; 繁和 藤田; 薫 阿部; 保廣 鳥澤

Yasuhiro Torisawa; Kaoru Abe; Yasuaki Muguruma; Shigekazu Fujita; Hidenori Ogawa; Naoto Utsumi; Masahiro Miyake

Kaoru Abe; Shigekazu Fujita; Masahiro Miyake; Yasuaki Muguruma; Hidenori Ogawa; Yasuhiro Torisawa; Naoto Utsumi

Yasuhiro Torisawa; Kaoru Abe; Yasuaki Muguruma; Shigekazu Fujita; Hidenori Ogawa; Naoto Utsumi; Masahiro Miyake