Yasubumi Shiina

Experimental Study And Clinical Application Of New Ceramic Endoprobe With Nd-YAG Laser; Endoscopic Hemostasis, Pyloroplasty And Cutting Biopsy

We have been studying endoscopic Nd-YAG laser therapies since 1979. In consequence, advantages of the contact method by using ceramic endoprobes were revealed123. Various endoprobes were developed by our studies, and the experimental studies and clinical applications of ceramic frosted probe and chisel probe with Nd-YAG laser were studied. Frosted probe was able to thrombose in the artery of the canine gastric submucosal layer by Nd-YAG laser irra-diation, and was applied to endoscopic hemostasis. Chisel probe was able to cut canine gastric mucosa at the power of 20watts and duration of 2.Osec. with Nd-YAG laser, and was applied to endoscopic pyloroplasty and cutting complete biopsy of submucosal tumor.

Experimental Studies Of Endoscopic Local Hyperthermia With Contact Nd-YAG Laser

We have been studying experimentally and clinically to evaluate the histological effects and safety of the therapeutic Nd-YAG laser endoscopy by the contact method with new ceramic endoprobes comparing wit Li those by the non-contact method with single quartz fiber. In this paper, we would like to discuss possibilities of clinical application of endoscopic local hyperthermia using Nd-YAG laser (Laserthermia) with computer control system. Newly developed computer controlled Laserthermia may possible to apply for the treatment of the malignant tumor in the gastrointestinal (GI) tract.

A Case Report of Borrmann 2 Type Gastric Cancer Complicated with Lung Cancer and Treated with Laserthermia

Abstract: A 52 year‐old female was admitted to our hospital for lung cancer. We performed upper gastrointestinal endoscopy for her complaint of epigastralgia, and diagnosed Borrmann 2 type gastric cancer on the posterior wall of the angle.

Development of hybrid laserthermia probe for single-channel G1 endoscope

The computer controlled Laserthermia system by the method of using double channel endoscope with the contact frosted probe and a thermocouple was reported previously.25 In this paper, the single channel method with the new single laser delivery system was studied experimentally. Especially hyperthermal effect by the newly developed Hybrid Laserthermia feedback probe(Hybrid probe) was discussed comparatively with the effects by the interstitial contact probe. The Hybrid probe could be possible to treat clinically more accurate Laserthermia in the near future.

Phase I study of cisapride. 3. Single intravenous dosing study.

A Phase l study on cisapride (R 51 619), a new gastrointestinal prokineti cagent, was conducted in 7 healthy Japanese male volunteers.The safety and phafmacokinetics of the drug were studied in single intravenous doses of 2 and 4 mg.The 2 men of group 1 received 2 mg, and the remaining 5 men (group2) were given 4 mg.There were no complaints about subjective symptoms.No abnormalities were seen in ECGs or laboratory tests.Among vital signs, a rise of pulse rate was observed after the 4 mg dosing.The time-concentration curves of cisapride could be fitted into a three compartment open model.The half-life of the unchanged drug in the π-phase, the α-phase, and the β-phase rate was 0.032, 0.90 and 6.4 hours respectively.The above results confirmed the safety of cisapride in single intravenous dosing in healthy male vorunteers.